2-Cyanophenol
- CAS No.
- 611-20-1
- Chemical Name:
- 2-Cyanophenol
- Synonyms
- 2-HYDROXYBENZONITRILE;2-hydroxy-benzonitril;CYANOPHENOL;O-CYANOPHENOL;Salicylnitrile;TIMTEC-BB SBB007959;2-Cyanopheno;2-CYANOPHENOL;SALICYLONITRILE;2 /4 CyanoPhenol
- CBNumber:
- CB9305904
- Molecular Formula:
- C7H5NO
- Molecular Weight:
- 119.12
- MDL Number:
- MFCD00002145
- MOL File:
- 611-20-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 92-95 °C (lit.) |
|---|---|
| Boiling point | 149 °C/14 mmHg (lit.) |
| Density | 1.1052 |
| vapor pressure | 0.17Pa at 25℃ |
| refractive index | 1.5372 |
| Flash point | 149°C/14mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 6.86(at 25℃) |
| color | Off-white to brown |
| Water Solubility | soluble |
| BRN | 1210029 |
| Henry's Law Constant | 2.8×101 mol/(m3Pa) at 25℃, Hilal et al. (2008) |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChI | 1S/C7H5NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H |
| InChIKey | CHZCERSEMVWNHL-UHFFFAOYSA-N |
| SMILES | Oc1ccccc1C#N |
| LogP | 1.66 at 30℃ |
| CAS DataBase Reference | 611-20-1(CAS DataBase Reference) |
| FDA UNII | 51RSM8K1VZ |
| NIST Chemistry Reference | Benzonitrile, 2-hydroxy-(611-20-1) |
| EPA Substance Registry System | Benzonitrile, 2-hydroxy- (611-20-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-45 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29269095 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Sens. 1B |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Cyanophenol price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 141038 | 2-Hydroxybenzonitrile 99% | 611-20-1 | 5g | $64.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 141038 | 2-Hydroxybenzonitrile 99% | 611-20-1 | 25g | $140 | 2026-04-30 | Buy |
| TCI Chemical | C1045 | 2-Cyanophenol >98.0%(GC)(T) | 611-20-1 | 5g | $27 | 2026-04-30 | Buy |
| TCI Chemical | C1045 | 2-Cyanophenol >98.0%(GC)(T) | 611-20-1 | 25g | $108 | 2026-04-30 | Buy |
| TRC | TRC-H808480-5G | 2-Hydroxybenzonitrile | 611-20-1 | 5g | $176 | 2026-06-03 | Buy |
2-Cyanophenol Chemical Properties,Uses,Production
Description
Cyanophenol is a vital molecule widely used to synthesize liquid crystal materials, medicines, spices, pesticides, corrosion inhibitors, etc. Cyanophenol is formed by substituting two hydrogen atoms of benzene molecules with hydroxyl and cyano groups, respectively. The cyano and hydroxyl groups are in the ring plane in the stable molecular structure. The hydroxyl group can have two different orientations relative to the cyano group. 2-cyanophenol, one of the Cyanophenol, is an essential ingredient in pesticides, spices, liquid crystal materials, etc. It is an especially critical intermediate for synthesizing methoxyacrylate fungicide mystrostrobin, widely used in agrochemicals, pharmaceutical chemicals, and other industries. The cyano group can strongly attract electrons. Replacing a hydrogen atom of the benzene ring by the cyano group usually increases the ionization energy (IE)[1].
Chemical Properties
2-Cyanophenol is a white to light yellow crystal powder with a pungent and bitter odor. It is partially soluble in water with a Pka value of 7.17. However, it is unstable when exposed to strong alkalis and oxidants. It is an important intermediate for the synthesis of the fungicide azoxystrobin and the antihypertensive drug Bunirolol.
Uses
2-Hydroxybenzonitrile is used as starting reagent during the synthesis of mono-alkoxyphenyloxazoline, furanoside.
Application
2-Cyanophenol is used in the synthesis of CDK/GSK-3 inhibitors, for usage as therapeutics in Alzheimer's disease (AD).
Preparation
A method for preparing 2-cyanophenol, which comprises the following steps: preparing salicylaldoxime; performing dehydration; and performing hydrolytic-acidification reaction, wherein in the dehydration, anhydride is adopted as a dehydrating agent; and in the hydrolytic-acidification reaction, a hydrolyticreagent is 10 to 30 mass percent alkaline solution, and the temperature of the hydrolytic-acidification reaction is 100 to 150℃.
Definition
ChEBI: 2-Cyanophenol is a member of benzenes and a nitrile.
Flammability and Explosibility
Not classified
Synthesis
2-Hydroxybenzonitrile can be synthesized by condensing salicylaldehyde with hydroxylamine hydrochloride to produce salicylaldoxime. Then, the salicylaldoxime is reacted with acetic anhydride followed by hydrolysis to yield 2-Hydroxybenzonitrile.
Process for the preparation of 2-hydroxybenzonitrile
storage
Store at 2°C - 8°C, close container well, protect from light.
References
[1] Na Li. “Vibrational spectra of 2-cyanophenol cation studied by the mass analyzed threshold ionization technique.” Chemical Physics Letters 792 (2022): Article 139402.
2-Cyanophenol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Shanghai zhiping biology science and technology co., ltd | 13621780388 | 494972302@qq.com | China | 39 | 58 |
| SHANDONG XINGRUNDA CHEMICAL CO.,LTD | 0534-18615348689 18615348689 | hclt1978@163.com | China | 35 | 58 |
| Jinan Linsheng Chemical Co., Ltd | 18769772272 | 739955573@qq.com | China | 1030 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
Related articles
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- Oct 23,2025
View Lastest Price from 2-Cyanophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Cyanophenol
611-20-1
|
$1.00-50.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2-Cyanophenol
611-20-1
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 2-Cyanophenol
611-20-1
|
$60.00-100.00 | 1kg | 98% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2-Cyanophenol
611-20-1
- $1.00-50.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Cyanophenol
611-20-1
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Cyanophenol
611-20-1
- $60.00-100.00
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
