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4-Hydroxy-3-methoxybenzonitrile

CAS No.
4421-08-3
Chemical Name:
4-Hydroxy-3-methoxybenzonitrile
Synonyms
AKOS B004154;VANILO NITRILE;VANILLONITRILE;4-Hydroxy-3-methoxyb;4-Cyano-2-methoxyphenol;2-methyl-3-phenyl-3-pentanol;3-Methoxy-4-Hydroxybenzonitrle;4-Hydroxy-3-Methoxybenzonitile;3-Methoxy-4-Hydroxybenzonitril;4-Hydroxy-3-methoxybenzonitriL
CBNumber:
CB5114702
Molecular Formula:
C8H7NO2
Molecular Weight:
149.15
MDL Number:
MFCD00001820
MOL File:
4421-08-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:25:12

4-Hydroxy-3-methoxybenzonitrile Properties

Melting point 85-87 °C (lit.)
Boiling point 270.21°C (rough estimate)
Density 1.2517 (rough estimate)
refractive index 1.5320 (estimate)
storage temp. Sealed in dry,Room Temperature
pka 7.84±0.18(Predicted)
form powder to crystal
color White to Light yellow to Light orange
InChI 1S/C8H7NO2/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,10H,1H3
InChIKey QJRWLNLUIAJTAD-UHFFFAOYSA-N
SMILES COc1cc(ccc1O)C#N
LogP 1.551 (est)
CAS DataBase Reference 4421-08-3(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-37/39-36/37/39
RIDADR  3439
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29269090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Hydroxy-3-methoxybenzonitrile price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 162604 4-Hydroxy-3-methoxybenzonitrile 98% 4421-08-3 25G $96.5 2026-04-30 Buy
TCI Chemical H0620 4-Hydroxy-3-methoxybenzonitrile >98.0%(GC)(T) 4421-08-3 5g $48 2026-04-30 Buy
TCI Chemical H0620 4-Hydroxy-3-methoxybenzonitrile >98.0%(GC)(T) 4421-08-3 25g $187 2026-04-30 Buy
Usbiological 279694 4-Hydroxy-3-methoxybenzonitrile Asreported 4421-08-3 50g $352 2026-06-03 Buy
Usbiological 279694 4-Hydroxy-3-methoxybenzonitrile Asreported 4421-08-3 100g $468 2026-06-03 Buy
Product number Packaging Price Buy
162604 25G $96.5 Buy
H0620 5g $48 Buy
H0620 25g $187 Buy
279694 50g $352 Buy
279694 100g $468 Buy

4-Hydroxy-3-methoxybenzonitrile Chemical Properties, Uses, Production

Chemical Properties

beige crystalline powder

Uses

4-Hydroxy-3-methoxybenzonitrile was used in the synthesis of 1,5-bis(4-cyano-2-methoxyphenoxy)-3-oxapentane.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 2293, 1948 DOI: 10.1021/ja01186a514

General Description

4-Hydroxy-3-methoxybenzonitrile on treatment with sodium perborate yields 4-hydroxy-3-methoxybenzamide.

121-33-5
4421-08-3
Synthesis of 4-Hydroxy-3-methoxybenzonitrile from Vanillin
Global Suppliers ( 180)
Supplier Tel Email Country ProdList Advantage
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd 027-83855310 13476018176 408614617@qq.com China 998 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13774476675 sales@fdc-chemical.com China 10000 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64

View Latest Price from 4-Hydroxy-3-methoxybenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Hydroxy-3-methoxybenzonitrile pictures 2026-09-17 4-Hydroxy-3-methoxybenzonitrile
4421-08-3
$75.00-100.00 1kg 99% 5000Ton HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
4-Hydroxy-3-methoxybenzonitrile pictures 2019-07-06 4-Hydroxy-3-methoxybenzonitrile
4421-08-3
$1.00 1KG 98% 100KG Career Henan Chemical Co
4-Hydroxy-3-methoxyb 4-Cyano-2-methoxyphenol 4-Hydroxy-3-Methoxybenzonitrile, 98% 25GR 4-Hydroxy-3-methoxybenzonitrile,98% 4-HYDROXY-3-METHOXYBENZONITRILE AKOS B004154 VANILLONITRILE VANILO NITRILE 3-Methoxy-4-Hydroxybenzonitrile 4-Hydroxy-3-Methoxybenzonitile 3-Methoxy-4-Hydroxybenzonitrle 3-Methoxy-4-Hydroxybenzonitril 4-Hydroxy-3-methoxybenzonitriL 2-methyl-3-phenyl-3-pentanol 4-Hydroxy-3-methoxybenzonitrile> Vanillonitrile(4-Hydroxy-3- Methoxybenzonitrile) 3-Methoxy-4-hydroxybenzonitrile (Isovanillonitrile) 4421-08-3 4421-8-3 44210-08-3 421-08-3 4421-08-31 920993 HOC6H3OCH3CN C8 to C9 Building Blocks Nitrogen Compounds Organic Building Blocks Cyanides/Nitriles Building Blocks C8 to C9 Chemical Synthesis Nitrogen Compounds Organic Building Blocks Anisoles, Alkyloxy Compounds & Phenylacetates Nitriles Phenols C8 to C9 Cyanides/Nitriles Nitrogen Compounds Aromatic Nitriles