3-Bromo-2-methoxybenzoic acid
- CAS No.
- 101084-39-3
- Chemical Name:
- 3-Bromo-2-methoxybenzoic acid
- Synonyms
- 3-Bromo-o-anisic Acid;3-BROMO-2-METHOXYBENZOIC;3-BROMO-2-METHOXYBENZOIC ACID;3-BROMO-2-METHOXYBENZOIC ACID 97;Benzoic acid, 3-bromo-2-methoxy-;3-Bromo-2-methoxybenzoic acid 97%;Ethanone,2-bromo-1-[5-(trifluoromethyl)phenyl]-
- CBNumber:
- CB6501307
- Molecular Formula:
- C8H7BrO3
- Molecular Weight:
- 231.04
- MDL Number:
- MFCD00045840
- MOL File:
- 101084-39-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 119-123 °C |
|---|---|
| Boiling point | 327.6±27.0 °C(Predicted) |
| Density | 1.625±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | soluble in Methanol |
| pka | 3.70±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | 1S/C8H7BrO3/c1-12-7-5(8(10)11)3-2-4-6(7)9/h2-4H,1H3,(H,10,11) |
| InChIKey | PIBPHOFXQUUPTM-UHFFFAOYSA-N |
| SMILES | COc1c(Br)cccc1C(O)=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2918999090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Bromo-2-methoxybenzoic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 694436 | 3-Bromo-2-methoxybenzoic acid 97% | 101084-39-3 | 5g | $61.3 | 2023-06-20 | Buy |
| TCI Chemical | B5262 | 3-Bromo-2-methoxybenzoic Acid | 101084-39-3 | 1G | $23 | 2026-04-30 | Buy |
| TCI Chemical | B5262 | 3-Bromo-2-methoxybenzoic Acid | 101084-39-3 | 5G | $70 | 2026-04-30 | Buy |
| Usbiological | 284518 | 2-Methoxy-3-bromobenzoic acid Asreported | 101084-39-3 | 2g | $333 | 2026-06-03 | Buy |
| Usbiological | 284518 | 2-Methoxy-3-bromobenzoic acid Asreported | 101084-39-3 | 5g | $470 | 2026-06-03 | Buy |
3-Bromo-2-methoxybenzoic acid Chemical Properties,Uses,Production
Uses
3-Bromo-2-methoxybenzoic Acid is a reactant that has been used in the preparation of biphenylic carboxamides as potent and selective CB2 receptor ligands.
Synthesis
3883-95-2
77-78-1
101084-39-3
General procedure for the synthesis of 3-bromo-2-methoxybenzoic acid from 3-bromo-2-hydroxybenzoic acid (360 g, 1.65 mol) and dimethyl sulfate (443 g, 3.50 mol): 3-bromo-2-hydroxybenzoic acid was added to a reaction vessel and acetone (1.8 L) was added as a solvent. Subsequently, anhydrous potassium carbonate (552 g, 4.0 mol) was added to the reaction system and dimethyl sulfate was added slowly and dropwise. The reaction mixture was carried out under reflux conditions until thin layer chromatography (TLC) showed the disappearance of the raw material. After completion of the reaction, the solid phase was washed with acetone, the organic phases were combined and concentrated. The concentrate was diluted with ethyl acetate, washed sequentially with water and saturated brine and finally dried with anhydrous sodium sulfate. The dried organic phase was filtered and concentrated to afford the target product 3-bromo-2-methoxybenzoic acid (355 g, 94% yield), which can be used directly in the next step of the reaction.
References
[1] Patent: CN106565625, 2017, A. Location in patent: Paragraph 0045-0046
[2] Journal of the Chemical Society, 1923, vol. 123, p. 1992
3-Bromo-2-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3836 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
View Lastest Price from 3-Bromo-2-methoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 3-Bromo-2-methoxybenzoic acid
101084-39-3
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-15 | 3-Bromo-2-methoxybenzoic acid
101084-39-3
|
$10.00 | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-04-22 | 3-Bromo-2-methoxybenzoic acid
101084-39-3
|
$30.00-100.00 | 1kg | 99.93% | 1000kg per week | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- 3-Bromo-2-methoxybenzoic acid
101084-39-3
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Bromo-2-methoxybenzoic acid
101084-39-3
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- 3-Bromo-2-methoxybenzoic acid
101084-39-3
- $30.00-100.00
- 99.93%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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