NB-598
- CAS No.
- 131060-14-5
- Chemical Name:
- NB-598
- Synonyms
- NB-598, 10 mM in DMSO;NB 598,NB-598,inhibit,NB598,Inhibitor;(E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine;Benzenemethanamine, 3-([3,3'-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl-
- CBNumber:
- CB6504005
- Molecular Formula:
- C27H31NOS2
- Molecular Weight:
- 449.67
- MDL Number:
- MFCD00898838
- MOL File:
- 131060-14-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ~60 °C |
|---|---|
| Boiling point | 530.7±50.0 °C(Predicted) |
| Density | 1.122±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: 14 mg/mL |
| pka | 7.04±0.50(Predicted) |
| form | solid |
| color | white |
| InChI | 1S/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+ |
| InChIKey | KIRGLCXNEVICOG-SOFGYWHQSA-N |
| SMILES | [s]1c(cc(c1)c3c[s]cc3)COc2cc(ccc2)CN(CC)C\C=C\C#CC(C)(C)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
NB-598 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14912 | NB-598 ≥98% | 131060-14-5 | 1mg | $29 | 2026-04-30 | Buy |
| Cayman Chemical | 14912 | NB-598 ≥98% | 131060-14-5 | 5mg | $135 | 2026-04-30 | Buy |
| Cayman Chemical | 14912 | NB-598 ≥98% | 131060-14-5 | 10mg | $253 | 2026-04-30 | Buy |
| ChemScene | CS-1274 | NB-598 98.71% | 131060-14-5 | 1mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-1274 | NB-598 98.71% | 131060-14-5 | 5mg | $234 | 2026-06-04 | Buy |
NB-598 Chemical Properties, Uses, Production
Uses
NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
NB-598 is a potent and specific inhibitor of mammalian squalene epoxidase (SQLE) th at suppresses triglyceride biosynthesis through the farnesol pathway. It decreases cholesterol levels in cells. NB-598 exhibit potent cytotoxic effects in subset of f neuroendocrine tumors, such as small cell lung cancers through accumulation of toxic squalene with in sensitive cancer cells.
References
[1] Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. DOI:10.1210/en.2008-0161
[2] Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. DOI:10.1016/0006-2952(93)90418-v
[3] Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51. PMID:8504141
NB-598 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing LAL Pharmaceutical Co., Ltd. | 010-010-62452898 13581984929 | jlzhang929@163.com | China | 91 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
