Methyl 5-carboxy-N-phenyl-2-1H-pyridone
- CAS No.
- 77837-09-3
- Chemical Name:
- Methyl 5-carboxy-N-phenyl-2-1H-pyridone
- Synonyms
- irfenidone 5-Carboxylate Methyl Ester;1,6-Dihydro-6-oxo-1-phenyl-nicotinic Acid Methyl Ester;Methyl 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate;Methyl 1,6-dihydro-6-oxo-1-phenyl-3-pyridinecarboxylate;Methyl 1,6-dihydro-6-oxo-1-phenylpyridine-3-carboxylate;6-Oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-1-phenyl-, methyl ester
- CBNumber:
- CB6506766
- Molecular Formula:
- C13H11NO3
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD07369505
- MOL File:
- 77837-09-3.mol
Methyl 5-carboxy-N-phenyl-2-1H-pyridone price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | M3395-51 | Methyl 5-Carboxy-N-phenyl-2-1H-pyridone | 77837-09-3 | 10mg | $418 | 2026-06-03 | Buy |
| Synthonix | M56722 | Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate 98% | 77837-09-3 | 50mg | $238 | 2026-05-06 | Buy |
| Synthonix | M56722 | Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate 98% | 77837-09-3 | 100mg | $370 | 2026-05-06 | Buy |
| Synthonix | M56722 | Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate 98% | 77837-09-3 | 250mg | $570 | 2026-05-06 | Buy |
| Synthonix | M56722 | Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate 98% | 77837-09-3 | 1g | $2280 | 2026-05-06 | Buy |
Methyl 5-carboxy-N-phenyl-2-1H-pyridone Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.
Synthesis
66171-50-4
98-80-6
77837-09-3
Methyl 6-hydroxynicotinate (6.0 g, 39.22 mmol) and phenylboronic acid (5.74 g, 47.06 mmol) were added copper(II) acetate monohydrate (11.76 g, 58.82 mmol), pyridine (6.32 mL, 78.43 mmol), and molecular sieves (4, 6.0 g) in dichloromethane (100 mL). The reaction mixture was stirred at ambient temperature for 12 h and then filtered. After standard post-extraction treatment the crude product was obtained and purified by silica gel column chromatography (100-200 mesh, eluent chloroform solution containing 1-2% methanol) to afford methyl 6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylate as a brown solid (5.0 g, 56% yield). The product has a melting point of 100-105°C. 1H NMR (400 MHz, CDCl3) δ 3.86 (s, 3H), 6.63 (d, J = 9.5 Hz, 1H), 7.36-7.55 (m, 5H), 7.91 (dd, J = 2.5, 9.9 Hz, 1H), 8.23 (d, J = 2.5 Hz, 1H); IR (KBr ) ν 3058, 2924, 2854, 1721, 1675, 1540, 1446, 1313, 1271, 1103 cm-1; MS 230 (M + 1).
References
[1] Patent: US2008/319026, 2008, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/122165, 2012, A2. Location in patent: Page/Page column 63
Methyl 5-carboxy-N-phenyl-2-1H-pyridone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Methyl 5-carboxy-N-phenyl-2-1H-pyridone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1996 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3698 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
