5-Carboxy-N-phenyl-2-1H-pyridone
- CAS No.
- 77837-08-2
- Chemical Name:
- 5-Carboxy-N-phenyl-2-1H-pyridone
- Synonyms
- 5-Carboxy Pirfenidone;5-carboxy-N-phenyl-2-pyridone;6-oxo-1-phenylpyridine-3-carboxylic acid;1,6-Dihydro-6-oxo-1-phenyl-3-pyridinecarboxylic Acid;6-oxo-1-phenyl-1,6-dihydro-3-pyridinecarboxylic acid;6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic Acid;3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-1-phenyl-
- CBNumber:
- CB6500825
- Molecular Formula:
- C12H9NO3
- Molecular Weight:
- 215.2
- MDL Number:
- MFCD07369218
- MOL File:
- 77837-08-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 282-284°C |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Light Yellow |
| FDA UNII | 260RWO9IY8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H302-H319-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
5-Carboxy-N-phenyl-2-1H-pyridone price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-C179020-50MG | 5-Carboxy-N-phenyl-2-1H-pyridone >95%(HPLC) | 77837-08-2 | 50mg | $780 | 2026-06-03 | Buy |
| TRC | TRC-C179020-25MG | 5-Carboxy-N-phenyl-2-1H-pyridone >95%(HPLC) | 77837-08-2 | 25mg | $432 | 2026-06-03 | Buy |
| TRC | TRC-C179020-10MG | 5-Carboxy-N-phenyl-2-1H-pyridone >95%(HPLC) | 77837-08-2 | 10mg | $192 | 2026-06-03 | Buy |
| Ambeed | A541554 | 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid 98% | 77837-08-2 | 100mg | $64 | 2026-06-05 | Buy |
| Ambeed | A541554 | 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid 98% | 77837-08-2 | 250mg | $141 | 2026-06-05 | Buy |
5-Carboxy-N-phenyl-2-1H-pyridone Chemical Properties, Uses, Production
Chemical Properties
Off-White Fluffy Solid
Uses
A metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.
Synthesis
77837-09-3
77837-08-2
General procedure for the synthesis of 6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid from methyl 6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylate: at 0 °C, lithium hydroxide monohydrate (0.366 g, 8.73 mmol) was added to a mixed solution of tetrahydrofuran (9 mL) and water (6 mL) containing methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate (1.0 g, 4.37 mmol) in a mixed solution of tetrahydrofuran (9 mL) and water (6 mL) and the reaction was stirred for 1 hour. After completion of the reaction, the reaction mixture was diluted with water and washed with ethyl acetate. Subsequently, the pH of the aqueous layer was adjusted to 2 with 2N hydrochloric acid and the precipitate was collected by filtration to afford 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid as a brown solid (0.740 g, 79% yield). The melting point of the product was 256-263°C. The structure of the product was determined by 1H NMR (400 MHz, DMSO-d6) δ 6.53 (d, J = 9.4 Hz, 1H), 7.40-7.49 (m, 5H), 7.87 (dd, J = 2.5, 9.8 Hz, 1H), 8.23 (d, J = 2.5 Hz, 1H); IR (KBr) ν 3446, 1708, 1645, 1577, 1263, 1228 cm-1; MS 214 (M-1) for characterization.
References
[1] Archiv der Pharmazie, 2013, vol. 346, # 9, p. 654 - 666
[2] Patent: US2008/319026, 2008, A1. Location in patent: Page/Page column 22
[3] Patent: WO2012/122165, 2012, A2. Location in patent: Page/Page column 63-64
[4] Patent: US2013/317059, 2013, A1. Location in patent: Paragraph 0042-0043
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 5079 - 5093
5-Carboxy-N-phenyl-2-1H-pyridone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Sheepchem Co., Ltd. | +86 (21) 6715-7650 | sheepchem@163.com | China | 993 | 60 |
| Zaozhuang Benefit Chemical Co., Ltd. | 0531-69958783 15508681609 | 1948129184@qq.com | China | 208 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Taifu Pharmaceutical Technology Co. LTD | 021-58111238 18930958102 | sales@taifupharm.com | China | 509 | 55 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9985 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2503 | 58 |
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