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DOTA di(tBu)ester

DOTA di(tBu)ester structure

CAS No.: 913542-71-9

Chemical Name:: DOTA di(tBu)ester

Synonyms: 2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid;DOTA(Diacids)-OH;DOTA di(tBu)ester;Zaterol impurity 3;Gadobutrol Impurity 91;Gadobutrol Impurity 243;DOTA-bis(tert-butyl)ester;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate or DOTA-bis(tert-butyl)ester

CBNumber:: CB65857245

Molecular Formula:: C24H44N4O8

Molecular Weight:: 516.63

MDL Number:

MOL File:: 913542-71-9.mol

MSDS File:: SDS

Last updated:2026-05-28 05:50:46

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DOTA di(tBu)ester Properties

Boiling point	644.7±55.0 °C(Predicted)
Density	1.133±0.06 g/cm3(Predicted)
pka	3.94±0.10(Predicted)
FDA UNII	CQS4G43QCN

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338

DOTA di(tBu)ester price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemPep	330408-5G	DOTA-di(t-Bu ester)	913542-71-9	5g	$2500	2026-06-04	Buy
ChemPep	330408-500MG	DOTA-di(t-Bu ester)	913542-71-9	500mg	$900	2026-06-04	Buy
ChemPep	330408-1G	DOTA-di(t-Bu ester)	913542-71-9	1g	$1250	2026-06-04	Buy
ChemPep	330408-100MG	DOTA-di(t-Bu ester)	913542-71-9	100mg	$600	2026-06-04	Buy
ChemScene	CS-0254987	DOTA-bis(tert-butyl)ester ≥98%	913542-71-9	100mg	$80	2026-06-04	Buy

Product number	Packaging	Price	Buy
330408-5G	5g	$2500	Buy
330408-500MG	500mg	$900	Buy
330408-1G	1g	$1250	Buy
330408-100MG	100mg	$600	Buy
CS-0254987	100mg	$80	Buy

DOTA di(tBu)ester Chemical Properties, Uses, Production

Uses

DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.

IC 50

RDC Bifunctional Chelator

DOTA di(tBu)ester Preparation Products And Raw materials

Raw materials

Preparation Products

DOTA di(tBu)ester Suppliers

Global Suppliers ( 39)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Send Pharmaceutical Technology Co., Ltd.	021-58088081 18317173152	Hailey@shsendpharm.com	China	843	55
Quzhou AMK BioTech Co., Ltd	0570-3081766 18357083060	sales@qzamkbio.com	China	1200	55
Shanghai GL Peptide Ltd.	+86-21-61263310 13764994101	fisherwang@glschina.com	China	8059	55
Shanghai Haozhixiang Biotechnology Co., Ltd	526763801 13301653310	526763801@qq.com	China	7983	55
Shanghai Changyan Chem & Tech Co., Ltd.	021-20242659 18930833303	sales@changyanchem.cn	China	4998	55
Grice Rand (Tianjin) Pharmaceutical Co., Ltd.	022-83705301 13752403750	2966024760@qq.com	China	814	55
Changzhou Hopschain Chemical Co.,Ltd.	85528066 13775048983	sales@hopschem.com	China	31548	55
Dezhou LonWel Pharmaceutical Technology Co., Ltd.	13761310616	39324283@qq.com	China	1363	58
Beyond Pharmaceutical Co., Ltd	0571-81953185 +86-15381198709	jasonyao@bydpharma.com	China	852	60
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4229	58

Supplier	Advantage
Shanghai Send Pharmaceutical Technology Co., Ltd.	55
Quzhou AMK BioTech Co., Ltd	55
Shanghai GL Peptide Ltd.	55
Shanghai Haozhixiang Biotechnology Co., Ltd	55
Shanghai Changyan Chem & Tech Co., Ltd.	55
Grice Rand (Tianjin) Pharmaceutical Co., Ltd.	55
Changzhou Hopschain Chemical Co.,Ltd.	55
Dezhou LonWel Pharmaceutical Technology Co., Ltd.	58
Beyond Pharmaceutical Co., Ltd	60
Xi'an Confluore Biological Technology Co., Ltd.	58

913542-71-9 (DOTA di(tBu)ester) Related Search:

Tri-tert-butyl 1 4 7 10-tetraazacyclodod 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Tri-t-butyl 1 4 7 10-tetraazacyclododeca Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate HydrobroMide 1,4,7,10-Tetraazacyclododecane-1,4-diacetic acid, 1,4-bis(1,1-dimethylethyl) ester

1,4,7,10-Tetraazacyclododecane-1-acetic acid,1,1-dimethylethyl ester

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DOTA di(tBu)ester 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester Zaterol impurity 3 1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate Gadobutrol Impurity 91 DOTA-bis(tert-butyl)ester 1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate or DOTA-bis(tert-butyl)ester Gadobutrol Impurity 243 Cytidine-6-13C-5-d, N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] (ACI) 2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid DOTA(Diacids)-OH 913542-71-9