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Tri-t-butyl 1 4 7 10-tetraazacyclododeca

Tri-t-butyl 1 4 7 10-tetraazacyclododeca structure

CAS No.: 122555-91-3

Chemical Name:: Tri-t-butyl 1 4 7 10-tetraazacyclododeca

Synonyms: tri-tert-butyl 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate;DOTA-NH;DO3A-t-Bu-ester(M-130);1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane;DO3AtBu;DO3A tert-butyl;DO-(CH2COOt-Bu)3;DO3A tert-Butyl ester;TETRAAZACYCLODODECANE-;Gadobutrol Impurity 102

CBNumber:: CB8497260

Molecular Formula:: C26H50N4O6

Molecular Weight:: 514.7

MDL Number:: MFCD05865261

MOL File:: 122555-91-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:55:46

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Tri-t-butyl 1 4 7 10-tetraazacyclododeca Properties

Melting point	181-183℃
Boiling point	561.6±50.0 °C(Predicted)
Density	1.022
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Low-Melting Solid
pka	9.57±0.20(Predicted)
color	White to Off-White
Sensitive	Hygroscopic
InChI	InChI=1S/C26H50N4O6/c1-24(2,3)34-21(31)18-28-12-10-27-11-13-29(19-22(32)35-25(4,5)6)15-17-30(16-14-28)20-23(33)36-26(7,8)9/h27H,10-20H2,1-9H3
InChIKey	NMHVTLJFPDOJOD-UHFFFAOYSA-N
SMILES	N1(CC(OC(C)(C)C)=O)CCNCCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC1
FDA UNII	CMX8GL4N3Y

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280a-P304+P340-P405-P501a-P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

HS Code

29339900

NFPA 704

	1
2		1

Tri-t-butyl 1 4 7 10-tetraazacyclododeca price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T2541	Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate >93.0%(N)	122555-91-3	200mg	$132	2021-12-16	Buy
Biosynth	FT60847	Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate	122555-91-3	25g	$900	2026-06-04	Buy
Biosynth	FT60847	Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate	122555-91-3	1g	$900	2026-06-04	Buy
Biosynth	FT60847	Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate	122555-91-3	10g	$900	2026-06-04	Buy
Biosynth	FT60847	Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate	122555-91-3	5g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
T2541	200mg	$132	Buy
FT60847	25g	$900	Buy
FT60847	1g	$900	Buy
FT60847	10g	$900	Buy
FT60847	5g	$900	Buy

Tri-t-butyl 1 4 7 10-tetraazacyclododeca Chemical Properties, Uses, Production

Uses

Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate with amide ligands bearing positively charged terbium complexes are used for sensitive detection of NADPH-dependent enzyme activities.

Synthesis

5292-43-3

294-90-6

TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA

122555-91-3

Under nitrogen protection, 1,4,7,10-tetraazacyclododecane (1 g, 5.81 mmol) was dissolved in anhydrous acetonitrile (20 ml) and cooled to 0 °C. Sodium bicarbonate (1.464 g, 17.44 mmol) was added to the reaction system under stirring conditions. Subsequently, anhydrous acetonitrile solution (10 ml) of tert-butyl bromoacetate (3.4 g, 17.44 mmol) was slowly added through a dropping funnel over a period of 1 hour. The reaction mixture was continued to be stirred at 0 °C for 3 h, followed by raising to room temperature and stirring for 45 h. The progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being dichloromethane (DCM): methanol (9:1), and the target product had an Rf value of 0.67. Upon completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to dryness under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being dichloromethane solution containing 2% methanol to afford tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (Compound 2) as a white powder in 83.5% yield.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 8, p. 918 - 920
[2] Tetrahedron Letters, 2009, vol. 50, # 31, p. 4459 - 4462
[3] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 12 - 20
[4] Patent: WO2014/200872, 2014, A1. Location in patent: Page/Page column 73; 77
[5] Organic and Biomolecular Chemistry, 2011, vol. 9, # 5, p. 1591 - 1599

Tri-t-butyl 1 4 7 10-tetraazacyclododeca Preparation Products And Raw materials

Raw materials

tert-Butyl bromoacetate tert-Butyl chloroacetate Cyclen Acetonitrile Sodium bicarbonate

Preparation Products

DOTA-mono-NHS tris(t-Bu ester) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) phenylMethyl ester

Tri-t-butyl 1 4 7 10-tetraazacyclododeca Suppliers

Global Suppliers ( 210)

Supplier	Tel	Email	Country	ProdList	Advantage
Grice Rand (Tianjin) Pharmaceutical Co., Ltd.	022-83705301 13752403750	2966024760@qq.com	China	814	55
Quzhou AMK BioTech Co., Ltd	0570-3081766 18357083060	sales@qzamkbio.com	China	1200	55
Henan Mengtai Pharmaceutical Technology Co., Ltd	17634413542	1959525201@qq.com	China	9011	58
Shanghai Minhan Pharmaceutical Technology Co., Ltd.	17612188245	2816925681@qq.com	China	8316	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	0431-80534353 19917294565	et@chemextension.com	China	3904	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55

Supplier	Advantage
Grice Rand (Tianjin) Pharmaceutical Co., Ltd.	55
Quzhou AMK BioTech Co., Ltd	55
Henan Mengtai Pharmaceutical Technology Co., Ltd	58
Shanghai Minhan Pharmaceutical Technology Co., Ltd.	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55

View Latest Price from Tri-t-butyl 1 4 7 10-tetraazacyclododeca manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	DO3A tert-Butyl ester 122555-91-3	$34.00-69.00			10g	TargetMol Chemicals Inc.
2025-06-07	DO-(CH2COOt-Bu)3 122555-91-3		25g	>95.00%	25g	Xian confluore Biological Technology Co., Ltd.
2025-04-04	TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA 122555-91-3		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

DO3A tert-Butyl ester
122555-91-3
$34.00-69.00
TargetMol Chemicals Inc.

DO-(CH2COOt-Bu)3
122555-91-3
$0.00
>95.00%
Xian confluore Biological Technology Co., Ltd.

TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA
122555-91-3
98%
Henan Aochuang Chemical Co.,Ltd.

122555-91-3 (Tri-t-butyl 1 4 7 10-tetraazacyclododeca) Related Search:

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1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane 1,4,7-Tris(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

1of3

TRI-T-BUTYL 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETATE 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic Acid Tri-tert-butyl Ester 1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)(DO3A-t-Butyl ester) DO3A-t-Bu-ester(M-130) 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, tris(1,1-diMethylethyl) ester 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETATE 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester DO3A tert-Butyl ester tert-butyl 2-[4,7-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate tert-Butyl 2-[4,7-bis(2-tert-butoxy-2-oxo-ethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate DO3AtBu 1,4,7, 1C-Tetraazacyclododecane-1,7-biadt-butyl acetate) 1,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate) DO3A tert-butyl tris(tert-butyl) 2,2,2-(1,4,7,10-tetraazacyclododecane-1,4,7 Gadobutrol Impurity A or 2,2'-(4,10-bis((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid DO-(CH2COOt-Bu)3 TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA ISO 9001：2015 REACH Tri-tert-butyl 1,4,7,1-tetraazacyclododecane-1,4,7-triacetate TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA 122555-91-3 Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,8-triacetate TETRAAZACYCLODODECANE- tert-butyl 2-{4,10-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododecan-1-yl}acetate Tri-tert-butyl 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacet Gadolinium alcohol impurity 19 Gadobutrol Impurity 102 Cyclen Derivatives 5(Zatetol impurity5） 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester (ACI) tri-tert-butyl 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetat 1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane DOTA-NH tri-tert-butyl 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate Tri-t-butyl 1 4 7 10-tetraazacyclododeca 122555-91-3 C26H50N4O6