Triisopropyl phosphite
- CAS No.
- 116-17-6
- Chemical Name:
- Triisopropyl phosphite
- Synonyms
- TRIISOPROPYL PHOS;Isopropyl phosphite;Triisopropyl phosphi;TRISOPROPYL PHOSHITE;tri-2-propylphosphite;tri-isopropylphosphit;TRI-I-PROPYLPHOSPHITE;Tri-2-propyl phosphite;TRIISOPROPYL PHOSPHITE;Triisopropoxyphosphine
- CBNumber:
- CB6674045
- Molecular Formula:
- C9H21O3P
- Molecular Weight:
- 208.24
- MDL Number:
- MFCD00008874
- MOL File:
- 116-17-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 63-64 °C11 mm Hg(lit.) |
|---|---|
| Density | 0.844 g/mL at 25 °C(lit.) |
| vapor pressure | <2 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 154 °F |
| storage temp. | -20°C |
| solubility | Insoluble in water, soluble in benzene and other organic solvents. |
| form | Liquid |
| Specific Gravity | 0.844 |
| color | Clear |
| Water Solubility | Insoluble |
| Sensitive | Moisture Sensitive |
| BRN | 1701528 |
| InChI | 1S/C9H21O3P/c1-7(2)10-13(11-8(3)4)12-9(5)6/h7-9H,1-6H3 |
| InChIKey | SJHCUXCOGGKFAI-UHFFFAOYSA-N |
| SMILES | CC(C)OP(OC(C)C)OC(C)C |
| LogP | 2 |
| CAS DataBase Reference | 116-17-6(CAS DataBase Reference) |
| FDA UNII | RJ7QU4YQUN |
| NIST Chemistry Reference | Phosphorous acid, tris(1-methylethyl) ester(116-17-6) |
| EPA Substance Registry System | Phosphorous acid, tris(1-methylethyl) ester (116-17-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 25-38-68 | |||||||||
| Safety Statements | 37-46-45-36/37 | |||||||||
| RIDADR | UN 3278 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TH2800000 | |||||||||
| F | 1-10 | |||||||||
| Hazard Note | Toxic/Flammable/Moisture Sensitive/ | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29209090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Skin Irrit. 2 |
|||||||||
| Hazardous Substances Data | 116-17-6(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Triisopropyl phosphite price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T67806 | Triisopropyl phosphite 95% | 116-17-6 | 100ml | $65.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001107 | Medronic acid impurity A European Pharmacopoeia (EP) Reference Standard | 116-17-6 | 60 μL | $170 | 2026-04-30 | Buy |
| Sigma-Aldrich | T67806 | Triisopropyl phosphite 95% | 116-17-6 | 500ml | $208 | 2026-04-30 | Buy |
| Strem Chemicals | 15-7000 | Tri-i-propylphosphite, min. 94% min.94% | 116-17-6 | 50g | $55 | 2026-04-30 | Buy |
| Strem Chemicals | 15-7000 | Tri-i-propylphosphite, min. 94% min.94% | 116-17-6 | 250g | $191 | 2026-04-30 | Buy |
Triisopropyl phosphite Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid; characteristic odor. Miscible with most common organic solvents; insoluble in water; hydrolyzes slowly in water; exposure to air should be minimum; high thermal stability. Combustible.
Uses
Triisopropyl phosphite can be used as a reactant:
- With Ru-based indenylidene complexes to form 1st generation complexes for metathesis reactions.
- In Perkow-type reaction to synthesize compounds containing polarized carbon-carbon double bonds.
- For the synthesis of phosphonohydrazines by reacting with arylamines and isoamyl nitrite.
It can also be used as an alternative to triphenylphosphine in Mitsunobu reaction to facilitate the isolation of products.
Uses
Intermediate for insecticides, component of vinyl stabilizers, lubricant additive, specialty solvent.
Synthesis
A solution of 180.3 g (3 mol) of anhydrous isopropyl alcohol and 447 g (477 ml, 3 mol) of freshly distilled diethylaniline in 1 l of dry petroleum ether (b.p. 40–60°) is placed in a 3-l three-necked flask fitted with a sealed stirrer, an efficient reflux condenser, and a 500-ml dropping funnel, which is charged with a solution of 137.5 g (87.5 ml, 1 mol) of freshly distilled phosphorus trichloride in 400 ml of dry petroleum ether (b.p. 40–60°). The flask is cooled in a cold-water bath. With vigorous stirring, the phosphorus trichloride solution is introduced at such a rate that the mixture boils gently towards the end of the addition. After the addition, which requires about 30 minutes, the mixture is heated under gentle reflux for about 1 hour with stirring. The suspension, containing a copious precipitate of diethylaniline hydrochloride, is then cooled and filtered with suction through a sintered glass funnel. The cake of the amine salt is well compressed and washed with five 100-ml. portions of dry petroleum ether (b.p. 40–60°). The filtrate and washings are combined and concentrated by distillation at water-bath temperature through a 75-cm. Vigreux column. The residue is transferred to a pear-shaped flask and distilled under a water-pump vacuum through a 75-cm. Vigreux column. After a small fore-run, the product Triisopropyl phosphite is collected. It has the following properties: b.p. 43.5°/1.0 mm; nD25 1.4080; d417 0.917.
Purification Methods
Distil it from sodium, under vacuum, through a column packed with glass helices. (This removes any dialkyl phosphonate.) [Ford-Moore & Williams J Chem Soc 1465 1947, Arbuzov Chem Ber 38 1171 1905, see Verkade & Coskren in Organo Phosphorus Compound (Kosolapoff & Maier eds) Wiley Vol 2 pp 1-187 1972, Beilstein 1 IV 1476.]
Triisopropyl phosphite Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changhe Chemical New Materials (Jiangsu) Co., Ltd | 18020181352 | jjx@china-ch.com | China | 94 | 58 |
| Nanjing Deweiqi Chemical Technology Co., Ltd | 18652911584 | 381854775@qq.com | China | 319 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from Triisopropyl phosphite manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Triisopropyl phosphite
116-17-6
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-02 | Triisopropyl phosphite
116-17-6
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2026-08-07 | Triisopropyl phosphite
116-17-6
|
$1.00 | 1KG | 99% | 20 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Triisopropyl phosphite
116-17-6
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Triisopropyl phosphite
116-17-6
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- Triisopropyl phosphite
116-17-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
