1,7-Dimethylxanthine
- CAS No.
- 611-59-6
- Chemical Name:
- 1,7-Dimethylxanthine
- Synonyms
- PARAXANTHINE;Paraxanthin;Caffeine EP Impurity F;1,7-dimethyl-3H-purine-2,6-dione;1,7-Dimethyl-1H-purine-2,6-dione, 1,7-Dimethylxanthine, 2,6-Dihydroxy-1,7-dimethylpurine, Paraxanthine;1,7-diMethyl-1H-purine-2,6(3H,7H)-dione;Paraxanthine-d3;Caffeine IMpurity F;1,7-DIMETHYLXANTHINE;Paraxanthine solution
- CBNumber:
- CB6674070
- Molecular Formula:
- C7H8N4O2
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD00005727
- MOL File:
- 611-59-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 294-296 °C (lit.) |
|---|---|
| Boiling point | 312.97°C (rough estimate) |
| Density | 1.3640 (rough estimate) |
| refractive index | 1.6700 (estimate) |
| Flash point | 9℃ |
| storage temp. | room temp |
| solubility | ethanol: 0.6mg/mL |
| form | solid |
| pka | pKa 8.5 (Uncertain) |
| color | white |
| BRN | 197907 |
| Stability | Store tightly sealed at RT |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13) |
| InChIKey | QUNWUDVFRNGTCO-UHFFFAOYSA-N |
| SMILES | N1(C)C2=C(NC(=O)N(C)C2=O)N=C1 |
| EWG's Food Scores | 1 |
| FDA UNII | Q3565Y41V7 |
| EPA Substance Registry System | 1H-Purine-2,6-dione, 3,7-dihydro-1,7-dimethyl- (611-59-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-24/25-45-36/37-16-7 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RV9380000 | |||||||||
| HS Code | 2933.59.9500 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | mmo-esc 150 mg/L CSHSAZ 16,337,52 | |||||||||
| NFPA 704 |
|
1,7-Dimethylxanthine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2000 | Caffeine Impurity F Pharmaceutical Secondary Standard; Certified Reference Material | 611-59-6 | 50MG | $751 | 2026-04-30 | Buy |
| Sigma-Aldrich | IMPC-051-03 | Paraxanthine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 611-59-6 | 1mL | $70.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | D5385 | 1,7-Dimethylxanthine ~98%, solid | 611-59-6 | 100mg | $232 | 2026-04-30 | Buy |
| Sigma-Aldrich | D5385 | 1,7-Dimethylxanthine ~98%, solid | 611-59-6 | 500mg | $922 | 2026-04-30 | Buy |
| TCI Chemical | D5696 | 1,7-Dimethylxanthine | 611-59-6 | 25MG | $71 | 2026-04-30 | Buy |
1,7-Dimethylxanthine Chemical Properties,Uses,Production
Description
Paraxanthine is an inhibitor of phosphodiesterase 9 (PDE9) and an antagonist of adenosine receptors A1 and A2 (Kis = 35 and 22 μM, respectively in equine forebrain tissues). It is the main metabolite of caffeine in humans, making up 80% of the three dimethylxanthine metabolites produced by caffeine demethylation. Paraxanthine increases locomotor activity and counteracts adenosine receptor agonist-induced motor depression in rats not habituated to caffeine. At a dose of 30 mg/kg, paraxanthine induces a significant increase in striatal cGMP and extracellular striatal dopamine concentrations in vivo. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
adenosine receptor agonist, CNS stimulant
Uses
1,7-Dimethylxanthine has been used for the quantification of caffeine by high-performance liquid chromatography (HPLC).
Uses
Paraxanthine is an adenosine receptor ligand and a major metabolite of caffeine.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: 1,7-dimethylxanthine is a dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals. It has a role as a central nervous system stimulant, a human xenobiotic metabolite, a human blood serum metabolite and a mouse metabolite.
benefits
1,7-Dimethylxanthine (Paraxanthine) has been shown to have several of the same nootropic benefits as caffeine, including improved cognition, short-term memory, sustained attention in healthy adults and beneficial cognitive effects in animal models of Parkinson’s disease. Moreover, the beneficial impacts on physical endurance and sports performance observed with caffeine use have also been suggested for paraxanthine. Mechanistically, some of these effects are mediated by a similar mechanism for caffeine and paraxanthine, which act as antagonists of adenosine receptors A1 and A2a. Despite these similarities in mechanisms, it has been reported that there are potential differences in adenosine receptor binding affinity, as paraxanthine exhibited higher binding potencies for adenosine A1 and A2A receptors in equine forebrain and a stronger locomotor activating effect in rats relative to caffeine. Furthermore, paraxanthine, but not other methylxanthines (caffeine, theobromine, theophylline), has been shown to potentiate nitric oxide neurotransmission, which has been associated with increased blood flow and subsequent changes in aerobic exercise performance and cardiovascular health.
General Description
Paraxanthine is a major plasma and urinary metabolite of caffeine. This xanthine derivative is, along with caffeine, a central nervous system stimulant. This Snap-N-Spike reference solution is applicable for caffeine quantitation in clinical toxicology or urine drug testing by LC-MS/MS or GC/MS.
Biochem/physiol Actions
Adenosine receptor ligand; major metabolite of caffeine
Safety Profile
An experimental teratogen. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
Source
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine that can be found naturally in small amounts in some foods, including green coffee beans, cotyledonary leaves of Coffea arabica, Theobroma cacao fruits, roasted coffee beans, citrus flowers and Sicilian orange flower honey. However, it is predominantly found as the major metabolite of caffeine, accounting for approximately 70%–72% of ingested caffeine[1].
References
[1] WICHITTRA TASSANEEYAKUL . Caffeine metabolism by human hepatic cytochromes p450: Contributions of 1A2, 2E1 and 3A isoforms[J]. Biochemical pharmacology, 1994, 47 10: Pages 1767-1776. DOI: 10.1016/0006-2952(94)90304-2
[2] CHI-CHUNG CHOU Thomas W V. Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues.[J]. American journal of veterinary research, 2003, 64 2: 216-224. DOI: 10.2460/ajvr.2003.64.216
[3] MARCO ORRú . Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans[J]. Neuropharmacology, 2013, 67: Pages 476-484. DOI: 10.1016/j.neuropharm.2012.11.029
[4] MASASHI OKURO. Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.[J]. Sleep, 2010, 33 7: 930-942. DOI: 10.1093/sleep/33.7.930
1,7-Dimethylxanthine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bolykey (Nanjing) New Materials Technology Co., Ltd | 18944488829 | 3434760588@qq.com | China | 23 | 58 |
| Beijing ECom Technology Co., Ltd. | 17710328343 | 3004011422@qq.com | China | 2567 | 58 |
| Shanghai Perry Pharmaceutical Technology Co., Ltd | 13661342810 | 83598451@qq.com | China | 246 | 58 |
| Shanghai Linchen Pharmaceutical Technology co.,LTD | 021-31606595 13761181955 | info@linchenpharm.com | China | 195 | 58 |
| Suzhou Sanyi Polymer Chemical Technology Co., Ltd. | 13951113810 | 170354953@qq.com | China | 127 | 58 |
| Yichang Chanod Biomedical Technology Co,LTD | 0717-6855399 15377615856 | sales@chanodpharm.com | China | 70 | 58 |
| Beijing Leaderherb Bio-Tech. Co., LTD. | 51288246 13366708252 | 300abc@sina.com | China | 91 | 58 |
| Suzhou Yuanrui Bio-Tech Co., Ltd | 18106132862 | info@yuanruibio.com | China | 292 | 58 |
| Jinan Jianfeng Chemical Co., Ltd. | 0531-88110457; 18954159893 | demi@pharmachemm.com | China | 205 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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- 1,7-Dimethylxanthine: Pharmacokinetics, Activities and Toxicology
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View Lastest Price from 1,7-Dimethylxanthine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Paraxanthine; 1, 7-Dimethylxanthine
611-59-6
|
1kg | 99% | 20ton | Jinan Jianfeng Chemical Co., Ltd | ||
 |
2026-09-09 | Paraxanthine
611-59-6
|
1kg | ≥ 99.0% HPLC | 20 tons | Suzhou Sanyi Chemical Co., Ltd. | ||
 |
2026-09-08 | Paraxanthin
611-59-6
|
$300.00 | 1KG | 99% | 80000 KG | Hangzhou multinpharma Co.,Ltd |
-
- Paraxanthine; 1, 7-Dimethylxanthine
611-59-6
- $0.00
- 99%
- Jinan Jianfeng Chemical Co., Ltd
-
- Paraxanthine
611-59-6
- ≥ 99.0% HPLC
- Suzhou Sanyi Chemical Co., Ltd.
-
- Paraxanthin
611-59-6
- $300.00
- 99%
- Hangzhou multinpharma Co.,Ltd
