6-Methoxyisoquinoline
- CAS No.
- 52986-70-6
- Chemical Name:
- 6-Methoxyisoquinoline
- Synonyms
- 6-METHOXY-ISOQUINOLINE;6-methoxylisoquinoline;Isoquinoline, 6-methoxy-;6-Methoxyisoquinoline 90%;6-Methoxy-2-azanaphthalene;6-ISOQUINOLINYL METHYL ETHER;6-Methoxyisoquinoline, 98% (Custom work);6-Methoxyisoquinoline ISO 9001：2015 REACH
- CBNumber:
- CB6680499
- Molecular Formula:
- C10H9NO
- Molecular Weight:
- 159.18
- MDL Number:
- MFCD04114861
- MOL File:
- 52986-70-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 88-95C/0.8 Torr |
|---|---|
| Density | 1.130±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane |
| form | Oil |
| pka | 6.11±0.10(Predicted) |
| color | Pale Yellow |
| InChI | InChI=1S/C10H9NO/c1-12-10-3-2-9-7-11-5-4-8(9)6-10/h2-7H,1H3 |
| InChIKey | XZNUJESLPUNSNO-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=C(OC)C=C2)C=CN=1 |
| CAS DataBase Reference | 52986-70-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2933499090 |
6-Methoxyisoquinoline price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR8562 | 6-Methoxyisoquinoline ≥95% | 52986-70-6 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR8562 | 6-Methoxyisoquinoline ≥95% | 52986-70-6 | 5g | $40 | 2026-06-04 | Buy |
| Apolloscientific | OR8562 | 6-Methoxyisoquinoline ≥95% | 52986-70-6 | 10g | $78 | 2026-06-04 | Buy |
| Activate Scientific | AS1986 | 6-Methoxyisoquinoline 95% | 52986-70-6 | 1g | $31 | 2026-06-04 | Buy |
| Activate Scientific | AS1986 | 6-Methoxyisoquinoline 95% | 52986-70-6 | 5g | $76 | 2026-06-04 | Buy |
6-Methoxyisoquinoline Chemical Properties,Uses,Production
Chemical Properties
Clear Oil
Uses
6-Methoxy Isoquinoline (cas# 52986-70-6) is a compound useful in organic synthesis.
Preparation
6-Methoxyisoquinoline synthesis: Using benzaldehyde as the starting material, m-methoxybenzaldehyde is obtained through nitration, reduction, diazotization, hydrolysis and methylation, and 3-methoxybenzaldehyde is obtained through condensation with nitromethane Shiff base and reduction of aluminum hydride -p-Phenylethylamine. The Pictet-Spengler reaction of 3-methoxyl-p-phenylethylamine and 40% aqueous formaldehyde produces 6-methoxyl-1,2,3,4-tetrahydroisoquinoline, and then obtains the target compound in dehydrogenation 6-Methoxyisoquinoline.
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 1939, 1947 DOI: 10.1021/ja01200a028
Synthesis
![Carbamic acid, N-(2,2-dimethoxyethyl)-N-[(dimethoxyphosphinyl)(4-methoxyphenyl)methyl]-, ethyl ester](/CAS/20210305/GIF/112435-06-0.gif)
112435-06-0
52986-70-6
General procedure for the synthesis of 6-methoxyisoquinoline from the compound (CAS:112435-06-0): the product obtained from step B (15) was dissolved in dichloromethane (200 mL) and the solution was cooled to 0 °C. Subsequently, titanium tetrachloride (86.0 g, 453 mmol) was slowly added and the reaction mixture was heated to reflux overnight. After the reaction was completed, the mixture was allowed to cool naturally to room temperature. Next, an aqueous solution (500 mL) of sodium hydroxide (73 g) was added and vigorously shaken for 10 minutes. The resulting titanium dioxide precipitate was removed by filtration and the filtrate was extracted with 3N hydrochloric acid. The pH of the aqueous phase was adjusted to 10 and the product in the aqueous phase was extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford 5.32 g (45% yield) of the target product 16 (6-methoxyisoquinoline) with mass spectral data of m/z = 160 (M + H)+. The product did not require further purification and could be used directly in the subsequent reaction.
References
[1] Journal of Organic Chemistry, 1983, vol. 48, # 19, p. 3344 - 3346
[2] Patent: WO2007/14921, 2007, A1. Location in patent: Page/Page column 74-75
6-Methoxyisoquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Lastest Price from 6-Methoxyisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 6-Methoxyisoquinoline
52986-70-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | 6-Methoxyisoquinoline
52986-70-6
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2023-08-18 | 6-Methoxyisoquinoline
52986-70-6
|
$20.00 | 1kg | 99.99% | 50000tons | Henan Bao Enluo International TradeCo.，LTD |
-
- 6-Methoxyisoquinoline
52986-70-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-Methoxyisoquinoline
52986-70-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 6-Methoxyisoquinoline
52986-70-6
- $20.00
- 99.99%
- Henan Bao Enluo International TradeCo.，LTD
