6-Methoxy-1,2,3,4-tetrahydro-isoquinoline
- CAS No.
- 42923-77-3
- Chemical Name:
- 6-Methoxy-1,2,3,4-tetrahydro-isoquinoline
- Synonyms
- m90104;6-Methoxy-1;AKOS BC-2988;Longimammatine;CHEMBRDG-BB 4101917;4-tetrahydroisoquinolin;6-Methoxy-1,2,3,4-tetrahydroisoquinolin;6-Methoxy-1,2,3,4-tetrahydroisochinolin;1,2,3,4-tetrahydro-6-methoxy-isoquinolin;1,2,3,4-Tetrahydro-6-methoxyisoquinoline
- CBNumber:
- CB8386342
- Molecular Formula:
- C10H13NO
- Molecular Weight:
- 163.22
- MDL Number:
- MFCD01717129
- MOL File:
- 42923-77-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 144°C/9mmHg(lit.) |
|---|---|
| Density | 1.044±0.06 g/cm3(Predicted) |
| refractive index | 1.5660 to 1.5700 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| form | Pale Yellow to Yellow Semi-Solid |
| pka | 10.02±0.20(Predicted) |
| color | Colorless to Light orange to Yellow |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-51 | |||||||||
| RTECS | NX5082000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933499090 | |||||||||
| NFPA 704 |
|
6-Methoxy-1,2,3,4-tetrahydro-isoquinoline price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2781 | 6-Methoxy-1,2,3,4-tetrahydroisoquinoline >96.0%(GC)(T) | 42923-77-3 | 1g | $243 | 2026-04-30 | Buy |
| TCI Chemical | M2781 | 6-Methoxy-1,2,3,4-tetrahydroisoquinoline >96.0%(GC)(T) | 42923-77-3 | 5g | $412 | 2021-12-16 | Buy |
| TRC | TRC-M268675-50MG | 6-Methoxy-1,2,3,4-tetrahydroisoquinoline | 50mg | $59 | 2026-06-03 | Buy | |
| TRC | TRC-M268675-250MG | 6-Methoxy-1,2,3,4-tetrahydroisoquinoline | 250mg | $103 | 2026-06-03 | Buy | |
| TRC | TRC-M268675-1G | 6-Methoxy-1,2,3,4-tetrahydroisoquinoline | 1g | $231 | 2026-06-03 | Buy |
6-Methoxy-1,2,3,4-tetrahydro-isoquinoline Chemical Properties, Uses, Production
Uses
6-Methoxy-1,2,3,4-tetrahydroisoquinoline is used in the synthesis of novel spirobicyclic Artemisinin (A777500) analogues for anti-tumor activity.
Synthesis
22246-12-4
42923-77-3
6.1.18 Synthesis of 6-methoxy-1,2,3,4-tetrahydroisoquinoline (35): to an anhydrous tetrahydrofuran (THF, 20 mL) solution of 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolone (34, 1.4 g, 7.9 mmol) was added slowly under nitrogen protection lithium aluminum hydride (LiAlH4, 601 mg, 15.8 mmol). The reaction mixture was stirred at 60 °C overnight. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched by sequential addition of water (0.6 mL) and 15% sodium hydroxide (NaOH) solution (0.6 mL), and stirring was continued for 30 minutes. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=20:1) to afford the target product 35 (1.06 g, 77% yield) as a yellow oil.1H NMR (400 MHz, CDCl3): δ 6.94 (d, J=8.0 Hz, 1H), 6.71 (d, J=8.0 Hz, 1H), 6.63 (s 1H), 4.00 (s, 2H), 3.78 (s, 3H), 3.16 (t, J=5.6Hz, 2H), 2.83 (t, J=5.2Hz, 2H).
References
[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 12, p. 2208 - 2216
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993, vol. 32, # 12, p. 1209 - 1213
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 207 - 219
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 789 - 801
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6855 - 6868
6-Methoxy-1,2,3,4-tetrahydro-isoquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Changzhou Xiaqing Technological Co., Ltd. | 88783621 15961106108 | john.chiang@xialichem.com | China | 143 | 70 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
View Latest Price from 6-Methoxy-1,2,3,4-tetrahydro-isoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
42923-77-3
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-03-06 | 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
42923-77-3
|
$1.00 | 1KG | 99% | 200kgs | Career Henan Chemical Co | |
 |
2019-07-06 | 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
42923-77-3
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
42923-77-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
42923-77-3
- $1.00
- 99%
- Career Henan Chemical Co
-
- 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
42923-77-3
- $1.00
- 99%
- Career Henan Chemical Co
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