2-Chloro-1-methyl-1H-imidazole
- CAS No.
- 253453-91-7
- Chemical Name:
- 2-Chloro-1-methyl-1H-imidazole
- Synonyms
- Azathioprine Impurity 10;2-Chloro-1-methylimidazole;2-CHLORO-1-METHYL-1H-IMIDAZOLE;2-Chloro-1-methylimidazole, 97+%;1H-Imidazole, 2-chloro-1-methyl-;2-Chloro-1-methyl-1H-imidazole 95%;1H-Imidazole,2-chloro-1-methyl-(9CI)
- CBNumber:
- CB6714743
- Molecular Formula:
- C4H5ClN2
- Molecular Weight:
- 116.55
- MDL Number:
- MFCD02179531
- MOL File:
- 253453-91-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -10℃ |
|---|---|
| Boiling point | 214.8±23.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | liquid |
| pka | 4.00±0.25(Predicted) |
| color | Yellow |
| CAS DataBase Reference | 253453-91-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933299090 | |||||||||
| NFPA 704 |
|
2-Chloro-1-methyl-1H-imidazole price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 230084 | 2-Chloro-1N-methylimidazole ≥95% (HPLC) ≥95%(HPLC) | 253453-91-7 | 250mg | $303 | 2026-06-03 | Buy |
| Usbiological | 230084 | 2-Chloro-1N-methylimidazole ≥95% (HPLC) ≥95%(HPLC) | 253453-91-7 | 1g | $465 | 2026-06-03 | Buy |
| Usbiological | 230084 | 2-Chloro-1N-methylimidazole ≥95% (HPLC) ≥95%(HPLC) | 253453-91-7 | 5g | $1336 | 2026-06-03 | Buy |
| Apolloscientific | OR10413 | 2-Chloro-1-methyl-1H-imidazole 96% | 253453-91-7 | 100mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR10413 | 2-Chloro-1-methyl-1H-imidazole 96% | 253453-91-7 | 250mg | $48 | 2026-06-04 | Buy |
2-Chloro-1-methyl-1H-imidazole Chemical Properties, Uses, Production
Uses
2-Chloro-1-methylimidazole is used in pharmaceuticals, drug candidates, ligands for transition metal catalysts and other molecular functional materials.
Synthesis
616-47-7
253453-91-7
Step A: Preparation of 2-chloro-1-methyl-1H-imidazole. N-methylimidazole (4.1 g, 0.05 mol) and anhydrous THF (25 mL) were added to a 300 mL three-necked round-bottomed flask equipped with a magnetic stirrer and a nitrogen inlet under nitrogen protection. Stirring was initiated and the reaction mixture was cooled to -78 °C. n-Butyllithium (2.5 M hexane solution, 22 mL, 0.055 mol) was added slowly via syringe and the reaction solution turned golden yellow. After maintaining stirring at this temperature for 30 minutes, a THF (25 mL) solution of hexachloroethane (13 g, 0.055 mol) was slowly added via syringe. Stirring of the reaction mixture was continued at -78 °C for 1 h. The reaction was subsequently quenched with saturated aqueous NaHCO3 solution (25 mL). The cooling bath was removed and after the reaction mixture was brought to room temperature, it was transferred to a 500 mL split funnel and extracted with ethyl acetate (150 mL). The organic layer was separated, washed sequentially with water and saturated saline and dried over anhydrous Na2SO4. After filtration, the solvent was removed by concentration under reduced pressure to give an oily crude product. The crude product was purified by distillation under reduced pressure to afford 2-chloro-1-methyl-1H-imidazole (4.75 g, 80% yield) as a colorless liquid with a boiling point of 54 °C/2 Torr. IR (thin film): 1515, 1420, 1367, 1277, 1127, 912, 740, 689, 665 cm-1. 1H NMR (400 MHz, CDCl3 ): δ 6.92 (d, J = 1.5 Hz, 1H), 6.85 (d, J = 1.5 Hz, 1H), 3.55 (s, 3H).13C NMR (100 MHz, CDCl3): δ 132.4, 128.0, 122.3, 33.5.HRMS (EI): m/z calculated value C4H6ClN2 [M+H]+, . 117.0223; measured value, 117.0220.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 25, p. 3855 - 3857
[2] Patent: US2005/250948, 2005, A1. Location in patent: Page/Page column 41
[3] Synthesis (Germany), 2015, vol. 47, # 5, p. 679 - 691
[4] Journal of Organometallic Chemistry, 1999, vol. 588, # 2, p. 155 - 159
[5] Journal of Organometallic Chemistry, 2000, vol. 601, # 2, p. 233 - 236
2-Chloro-1-methyl-1H-imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-1-methyl-1H-imidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
View Latest Price from 2-Chloro-1-methyl-1H-imidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | 2-Chloro-1-methyl-1H-imidazole
253453-91-7
|
$6.60 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 2-Chloro-1-methyl-1H-imidazole
253453-91-7
- $6.60
- 97%-99%
- Career Henan Chemical Co
