7-Nitro-1-tetralone
- CAS No.
- 40353-34-2
- Chemical Name:
- 7-Nitro-1-tetralone
- Synonyms
- 7-NITROTETRALONE;7-NITRO-3,4-DIHYDR;7-NITRO-1-TETRALONE;7-NITROTETRA-1-LONE;7-nitro-1-tetrralone;7-Nitrotetralin-1-one;7-Nitrotetra-1-lone 98%;7-Nitro-1-tetralone,97%;3,4-dihydro-7-nitro-1(2h)-naphthalenon;7-NITRO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE
- CBNumber:
- CB6715669
- Molecular Formula:
- C10H9NO3
- Molecular Weight:
- 191.18
- MDL Number:
- MFCD00019661
- MOL File:
- 40353-34-2.mol
- MSDS File:
- SDS
| Melting point | 108-109°C |
|---|---|
| Boiling point | 349.1±31.0 °C(Predicted) |
| Density | 1.322±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Orange to Green |
| BRN | 1570515 |
| InChI | 1S/C10H9NO3/c12-10-3-1-2-7-4-5-8(11(13)14)6-9(7)10/h4-6H,1-3H2 |
| InChIKey | GWAQYWSNCVEJMW-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc2CCCC(=O)c2c1 |
| CAS DataBase Reference | 40353-34-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NIST Chemistry Reference | 1(2H)-naphthalenone, 3,4-dihydro-7-nitro-(40353-34-2) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P261-P271 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-52 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| RTECS | QK5025000 | |||||||||
| HS Code | 2914790090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00954, | |||||||||
| NFPA 704 |
|
7-Nitro-1-tetralone price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | N0945 | 7-Nitro-1-tetralone >98.0%(GC) | 40353-34-2 | 1g | $31 | 2026-04-30 | Buy |
| TCI Chemical | N0945 | 7-Nitro-1-tetralone >98.0%(GC) | 40353-34-2 | 5g | $88 | 2026-04-30 | Buy |
| AstaTech | 23007 | 7-NITROTETRALONE 98% | 40353-34-2 | 1G | $29 | 2026-04-30 | Buy |
| AstaTech | 23007 | 7-NITROTETRALONE 98% | 40353-34-2 | 5G | $72 | 2026-04-30 | Buy |
| AstaTech | 23007 | 7-NITROTETRALONE 98% | 40353-34-2 | 10G | $108 | 2026-04-30 | Buy |
7-Nitro-1-tetralone Chemical Properties,Uses,Production
Application
7-Nitro-3,4-Dihydro-2H-1-naphthone is a ketone derivative that can be used as a pharmaceutical intermediate.
Chemical Properties
earthy yellow powder
Synthesis
529-34-0
40353-34-2
General procedure for the synthesis of 7-nitro-3,4-dihydro-2H-1-naphthalenone from 1-tetralone: Concentrated sulfuric acid (60 mL) was cooled to 0 °C in an ice bath. 1-Tetrahydronaphthalenone (8 g, 54.7 mmol) was added with stirring, and then potassium nitrate (6 g, 59.3 mmol, 1.08 eq.) dissolved in concentrated sulfuric acid (18 mL) was slowly added dropwise through a dropping funnel, controlling the reaction temperature to no more than 15 °C. The reaction was carried out at a controlled temperature of 15 °C. The reaction was completed with the addition of potassium nitrate (6 g, 59.3 mmol, 1.08 eq.). After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour. The reaction was quenched by pouring the reaction solution into crushed ice, the precipitate was collected by filtration and washed with distilled water. After drying, recrystallization was carried out through a solvent mixture of ethanol/water (1:1) to give 7-nitro-3,4-dihydro-2H-1-naphthalenone (8.5 g, 81% yield) as a light yellow solid with a melting point of 104-106 °C. The product was analyzed by infrared spectroscopy (IR, film) showing characteristic absorption peaks located at 1675 cm1, 1500 cm1 and 1340 cm1. The nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, CDCl3) data are as follows: δ 2.18-2.25 (2H, m, CH2), 2.75 (2H, t, J = 6.8 Hz, CH2), and 3.10 (2H, t, J = 6.1 Hz, CH2), 7.45 (1H, d, J = 8.4 Hz, ArH), 8.30 (1H, dd, J = 2.4 Hz, 8.4 Hz, ArH), 8.86 (1H, d, J = 2.4 Hz, ArH).
References
[1] Patent: WO2004/87124, 2004, A1. Location in patent: Page/Page column 47-48
[2] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 237 - 249
[3] Tetrahedron Letters, 1994, vol. 35, # 38, p. 7061 - 7064
[4] Justus Liebigs Annalen der Chemie, 1927, vol. 451, p. 53
[5] Journal of the Chemical Society. Perkin transactions 1, 1969, vol. 10, p. 1376 - 1378
7-Nitro-1-tetralone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai SunSyn Pharmaceutical Co., Ltd. | 021-18621020637 18621020637 | sales@sunsynpharma.com | China | 297 | 55 |
| Hefei Jiete Pharmaceutical Technology Co., Ltd | 0551-18256521115 18256521115 | 2788434637@qq.com | China | 32 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Bridge Organics | +1269-649-4200 | ab@bridgeorganics.com | United States | 160 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Lastest Price from 7-Nitro-1-tetralone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-04 | 7-Nitro-1-tetralone
40353-34-2
|
1g | 98%minHPLC | 50kgs/month | Shanghai Rlavie Technology Co ltd | ||
 |
2019-12-26 | 7-Nitro-1-tetralone
40353-34-2
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 7-Nitro-1-tetralone
40353-34-2
- 98%minHPLC
- Shanghai Rlavie Technology Co ltd
-
- 7-Nitro-1-tetralone
40353-34-2
- $1.00
- 99%
- Career Henan Chemical Co
