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ALLOXAN MONOHYDRATE

ALLOXAN MONOHYDRATE Structure
ALLOXAN MONOHYDRATE structure
CAS No.
2244-11-3
Chemical Name:
ALLOXAN MONOHYDRATE
Synonyms
Alloxan99%;MESOXALYLUREA;Alloxan, 98.5%;5,6-DIOXYURACIL;Urea monohydrate;ALLOXANE DIHYDRATE;ALLOXAN MONOHYDRATE;Alloxan Momohydrate;ALLOXAN ( HYDRATE) GR;LABOTEST-BB LT00138148
CBNumber:
CB6771957
Molecular Formula:
C4H4N2O5
Molecular Weight:
160.09
MDL Number:
MFCD00149399
MOL File:
2244-11-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:29:24
Product description Number Pack Size Price
Alloxan monohydrate 98% A7413 10g $56
Alloxan monohydrate 98% A7413 25g $87.1
Alloxan Monohydrate A0216 5G $32
Alloxan Monohydrate >98.0%(T) A0216 25g $98
Alloxan (hydrate) ≥98% 9002196 5g $36
More product size
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ALLOXAN MONOHYDRATE Properties

Melting point 255 °C (dec.)(lit.)
storage temp. 2-8°C
solubility H2O: may be hazy yellow
form Crystalline Powder
color Off-white to beige-yellow
Water Solubility Soluble in water, ethanol, acetone, glacial acetic acid and methanol. Slightly soluble in chloroform, petroleum ether, toluene, ethyl acetate and acetic anhydride. Insoluble in ether.
Sensitive Air Sensitive
Merck 14,282
BRN 5309394
InChI InChI=1S/C4H2N2O4.H2O/c7-1-2(8)5-4(10)6-3(1)9;/h(H2,5,6,8,9,10);1H2
InChIKey DSXMTJRUNLATRP-UHFFFAOYSA-N
SMILES O=C1C(NC(=O)NC1=O)=O.O
CAS DataBase Reference 2244-11-3(CAS DataBase Reference)
FDA UNII O2AAP9F8B6
EPA Substance Registry System 2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate (2244-11-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  36-26-36/37
WGK Germany  3
RTECS  UW0492000
TSCA  Yes
HS Code  29335995
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
NFPA 704
0
1 0

ALLOXAN MONOHYDRATE price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A7413 Alloxan monohydrate 98% 2244-11-3 10g $56 2026-04-30 Buy
Sigma-Aldrich A7413 Alloxan monohydrate 98% 2244-11-3 25g $87.1 2026-04-30 Buy
TCI Chemical A0216 Alloxan Monohydrate 2244-11-3 5G $32 2026-04-30 Buy
TCI Chemical A0216 Alloxan Monohydrate >98.0%(T) 2244-11-3 25g $98 2026-04-30 Buy
Cayman Chemical 9002196 Alloxan (hydrate) ≥98% 2244-11-3 5g $36 2026-04-30 Buy
Product number Packaging Price Buy
A7413 10g $56 Buy
A7413 25g $87.1 Buy
A0216 5G $32 Buy
A0216 25g $98 Buy
9002196 5g $36 Buy

ALLOXAN MONOHYDRATE Chemical Properties,Uses,Production

Chemical Properties

Off-white to beige-yellowish crystalline powder

Uses

specific cytotoxin (beta pacreatic cell)

Uses

A cytotoxic compound, Alloxan Monohydrate causes oxidative base damage to nuclear DNA.

Uses

Cytotoxic compound that causes oxidative base damage to nuclear DNAAlloxan monohydrate is used as a precursor to prepare purple dye murexide. It is also used in research models to induce diabetes and destroy beta cells. Further, it is a strong oxidizing agent and it forms a hemiacetal with its reduced reaction product dialuric acid.

Safety Profile

Poison by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

The original tetracosane was prepared by oxidizing uric acid with nitric acid, or by oxidizing barbituric acid with chromium trioxide.

in vivo

Alloxan hydrate can be used in animal modeling to create diabetes models. Administration of Alloxan hydrate leads to a sharp increase in blood glucose levels in mice, peaking at 45 minutes. Two hours after administration, blood glucose levels decrease to near-hypoglycemic levels, reaching the lowest blood glucose level at 6 hours[3].

Induction of Diabetes[3]
Background
Alloxan hydrate induces diabetes by destroying the pancreas that produces insulin and has a toxic effect on β cells.
Specific Modeling Methods
Mice: albino NMRI female 20-25 g
Administration: 70 mg/kg i.v.
Note
(1) Alloxan hydrate is dissolved in hydrochloric acid (pH=5) and administered via tail vein injection within 10 minutes after dissolution.
(2) Blood sampling was done through the eye socket, with 25μL and 250μL taken to measure blood glucose and plasma insulin levels, respectively.
(3) Blood glucose and plasma insulin levels were measured using enzyme and immunoassays, respectively. Mice with blood glucose levels reaching or exceeding 200 mg/100 mL are considered diabetic.
Modeling Indicators
Molecular changes: Blood sugar levels rise, glycogen in the liver decreases, and insulin levels increase during hypoglycemia.
Correlated Product(s): Streptozotocin (HY-13753)
Opposite Product(s): /

Purification Methods

Recrystallisation from H2O gave the tetrahydrate in large prisms or rhombs. On heating at 100o, or on exposure to air, this is converted to the monohydrate. Dissolve it in its own weight of boiling H2O and cool it for several days below 0o; the tetrahydrate crystallises from solution much more slowly when free from HNO3. It is less soluble in bicarbonate solutions than in H2O. Drying the solid over H2SO4 yields the monohydrate. The anhydrous crystals can be obtained by recrystallisation from dry Me2CO or AcOH followed by washing with dry Et2O, or by sublimation in a vacuum. On heating it turns pink at 230o and decomposes at ca 256o. It is acidic to litmus. [Hartman & Sheppard Org Synth Coll Vol III 37 1955.] It forms a compound with urea which crystallises from H2O in yellow needles that become red at 170o and decompose at 185-186o. [Beilstein 24 H 500, 24 I 428, 24 II 301, 24 III/IV 2137.]

ALLOXAN MONOHYDRATE Preparation Products And Raw materials

Raw materials

Barbituric acid Chromium(VI) oxide Acetic acid

Preparation Products

6,7-DICHLORO-QUINOXALIN-2-YLAMINE

ALLOXAN MONOHYDRATE Suppliers

Global( 258)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
RongNa Biotechnology Co.,Ltd 		+86-86-13583358881 +8618560316533 Brad@rongnabiotech.com China 3366 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5982 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
RongNa Biotechnology Co.,Ltd 		58
Dideu Industries Group Limited 		58
Wuhan Fortuna Chemical Co., Ltd 		58

View Lastest Price from ALLOXAN MONOHYDRATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ALLOXAN MONOHYDRATE pictures 2026-05-27 ALLOXAN MONOHYDRATE
2244-11-3
 0.99 RongNa Biotechnology Co.,Ltd
Alloxan Monohydrate pictures 2026-05-27 Alloxan Monohydrate
2244-11-3
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Alloxan monohydrate pictures 2026-05-11 Alloxan monohydrate
2244-11-3
 US $0.00 / removed 99.42% 10g TargetMol Chemicals Inc.

ALLOXAN MONOHYDRATE Spectrum

ALLOXAN MONOHYDRATE(2244-11-3)1HNMR

2244-11-3(ALLOXAN MONOHYDRATE)Related Search:

Thymidine URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT 5-Azacytidine Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) trans-Zeatin-riboside
Adenine Guanosine-5'-diphosphate disodium salt Adenosine 3',5'-cyclic monophosphate sodium salt Adenosine triphosphate Xanthine
N,N'-Diphenylurea Uridine 5'-diphosphoglucose disodium salt Oxalic acid ALLOXAN TETRAHYDRATE Alloxan
ALLOXAN MONOHYDRATE Oxalic acid dihydrate ALLOXAN MONOHYDRATE, (MESOXALYLUREA MONOHYDRATE)

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2,4,5,6(1H,3H)-Pyrimidinetetrone, 2,4,5,6-Tetraoxypyrimidine, 5,6-Dioxyuracil 2,4,5,6-tetraoxohexahydropyrimidinehydrate mesoxalylcarbamidemonohydrate LABOTEST-BB LT00138148 MESOXALYLUREA MESOXALYLUREA, MONOHYDRATE 5,6-DIOXYURACIL 5,6-DIOXYURACIL MONOHYDRATE ALLOXANE DIHYDRATE ALLOXAN MONOHYDRATE 2,4,5,6-TETRAOXYPYRIMIDINE 2,4,5,6-TETRAOXYPYRIMIDINE MONOHYDRATE 2,4,5,6(1H,3H)-PYRIMIDINETETRONE MONOHYDRATE Alloxan99% ALLOXAN ( HYDRATE) GR Pyrimidine-2,4,5,6(1H,3H)-tetrone hydrate 2,4,5,6(1h,3h)-pyrimidinetetronehydrate Alloxan monohydrate,98% Alloxan Momohydrate Alloxan Monohydrate, 98% 25GR PyriMidine-2,4,5,6(1H,3H)-tetraone hydrate 1,3-Diazinane-2,4,5,6-tetrone hydrate Alloxan monohydrate ,99% 2,4,5,6(1H,3H)-PyriMidinetetrone,hydrate (1:1) Alloxan monohydrate≥ 98% (Assay) 2,4,5,6(1H,3H)-Pyrimidinetetrone monohydrate 2,4,5,6(1H,3H)-Pyrimidinetetrone monohydrate Urea monohydrate Alloxan Monohydrate> ALLOXAN MONOHYDRATE USP/EP/BP Alloxan, 98.5% N-[(E)-3-methylbutylideneamino]-2,4-dinitroaniline Alloxan Monohydrate extrapure, 98% Alloxan Monohydrate, ≥ 98.0% Alloxan Monohydrate 98% Extra Pure 2244-11-3 2244-13-3 2244-11-03 125-95-2 CONHCONHCOCOH2 C4H2N2O4xH2O C4H2N2O4H2O Building Blocks Heterocyclic Building Blocks Pyrimidines buildingblock Pyridines, Pyrimidines, Purines and Pteredines Active Pharmaceutical Ingredients