1-Cyanocyclobutanecarboxylic acid ethyl ester
- CAS No.
- 28246-87-9
- Chemical Name:
- 1-Cyanocyclobutanecarboxylic acid ethyl ester
- Synonyms
- Ethyl 1-cyanocyclobutane-1-carboxylate;ethyl 1-cyanocyclobutanecarboxylate;1-Cyanocyclobutanecarboxylic acid ethyl ester;1-Cyano-Cyclobutanecarboxylic Acid Ethyl Este;Cyclobutanecarboxylic acid, 1-cyano-, ethyl ester;*Guaiacol Impurity 1 (Guaiacol EP Impurity A)(Pyrocatechol);(Z)-3-hydroxy-1-[5-(thiophen-2-ylmethyl)-2-furanyl]-3-(1H-1,2,4-triazol-5-yl)-2-propen-1-one
- CBNumber:
- CB6801258
- Molecular Formula:
- C8H11NO2
- Molecular Weight:
- 153.18
- MDL Number:
- MFCD04114273
- MOL File:
- 28246-87-9.mol
- MSDS File:
- SDS
| Boiling point | 215.5-216 °C(Press: 762 Torr) |
|---|---|
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C8H11NO2/c1-2-11-7(10)8(6-9)4-3-5-8/h2-5H2,1H3 |
| InChIKey | VPAQDMAYKQBDLT-UHFFFAOYSA-N |
| SMILES | C1(C#N)(C(OCC)=O)CCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P280-P301+P312-P302+P352 |
| HS Code | 2926907090 |
1-Cyanocyclobutanecarboxylic acid ethyl ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DBA24687 | Ethyl 1-cyanocyclobutanecarboxylate | 28246-87-9 | 50g | $590 | 2026-06-04 | Buy |
| Apolloscientific | OR315354 | Ethyl 1-cyanocyclobutanecarboxylate >97% | 28246-87-9 | 5g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR315354 | Ethyl 1-cyanocyclobutanecarboxylate >97% | 28246-87-9 | 25g | $74 | 2026-06-04 | Buy |
| Apolloscientific | OR315354 | Ethyl 1-cyanocyclobutanecarboxylate >97% | 28246-87-9 | 100g | $285 | 2026-06-04 | Buy |
| Apolloscientific | OR315354 | Ethyl 1-cyanocyclobutanecarboxylate >97% | 28246-87-9 | 500g | $1298 | 2026-06-04 | Buy |
1-Cyanocyclobutanecarboxylic acid ethyl ester Chemical Properties, Uses, Production
Uses
1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process.
Synthesis
4-(9>-cyclopentyl-5'-methyl-6>-oxo-5>,6>,8>,9>- tetrahydrospiro[cyclobutane-l,7'-pyrimido[4,5-b][l,4]diazepine]-2'-ylamino)-3- methoxybenzoic acid; [0521] Ethyl 1-cyanocyclobutanecarboxylate; To a solution of sodium ethoxide (21wt% in EtOH, 5.79 rnL, 15.5 mmol) in EtOH (25 mL), was added ethyl cyanoacetate(1.12 mL, 10.5 mmol), followed shortly thereafter by 1,1-dibromopropane (1.12 mL, 10 mmol). The reaction mixture was refluxed for 3 hrs. It was then concentrated, and diluted to ethyl acetate. The organic layer was washed with NaHCCh, brine, water, dried over Na2SO4 and concentrated in vacuo to obtain ethyl 1-cyanocyclobutanecarboxylate (1.17 g, 74% yield) as a red liquid. It was used directly for next step reaction.
1-Cyanocyclobutanecarboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| ChangZhou SIDU chemical Co., Ltd. | 0519-81291281 18015082300 | siduchem@hotmail.com | China | 274 | 62 |
| Shanghai Famo Bio-chemical Technology Company Ltd. | 021-36680027 15821745250 | fengqiang@famobiotech.com | China | 494 | 56 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Taizhou Yikang Chemical Co., Ltd. | 0576-88501337 18057652630 | sales@yikangchemicals.com | China | 272 | 58 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9883 | 50 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3698 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
View Latest Price from 1-Cyanocyclobutanecarboxylic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
28246-87-9
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-01-13 | 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
28246-87-9
|
$1.00 | 1KG | 98%-99.9% | 100kg | Career Henan Chemical Co |
-
- 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
28246-87-9
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
28246-87-9
- $1.00
- 98%-99.9%
- Career Henan Chemical Co
