1-Bromo-2,3-dimethoxybenzene
- CAS No.
- 5424-43-1
- Chemical Name:
- 1-Bromo-2,3-dimethoxybenzene
- Synonyms
- 3-Bromoveratrole;1-Bromo-2,3-dimethox;3-Bromoveratrole, 95%;1-BROMO-2,3-DIMETHOXYBENZENE;Benzene, 1-bromo-2,3-dimethoxy-;1-[(5-bromo-2,4-dimethoxyphenyl)methyl]-4-(2,5-dimethylphenyl)piperazine
- CBNumber:
- CB6836797
- Molecular Formula:
- C8H9BrO2
- Molecular Weight:
- 217.06
- MDL Number:
- MFCD00185638
- MOL File:
- 5424-43-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2902900000 | |||||||||
| NFPA 704 |
|
1-Bromo-2,3-dimethoxybenzene price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR310088 | 1-Bromo-2,3-dimethoxybenzene 98% | 5424-43-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR310088 | 1-Bromo-2,3-dimethoxybenzene 98% | 5424-43-1 | 5g | $64 | 2026-06-04 | Buy |
| Activate Scientific | AS39312 | 1-Bromo-2,3-dimethoxybenzene 95% | 5424-43-1 | 1g | $48 | 2026-06-04 | Buy |
| Apolloscientific | OR310088 | 1-Bromo-2,3-dimethoxybenzene 98% | 5424-43-1 | 25g | $268 | 2026-06-04 | Buy |
| Activate Scientific | AS39312 | 1-Bromo-2,3-dimethoxybenzene 95% | 5424-43-1 | 5g | $130 | 2026-06-04 | Buy |
1-Bromo-2,3-dimethoxybenzene Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Synthesis
91-16-7
5424-43-1
To a stirred solution of N,N,N',N'-tetramethylethylenediamine (TMEDA, 5.43 mL, 36.19 mmol, 1.0 eq.) in anhydrous ethyl ether (Et2O, 100 mL) was slowly added n-butyllithium (n-BuLi, 22.6 mL, 36.19 mmol, 1.0 eq., 1.6 M hexane solution) at room temperature. The mixture was stirred for 10 minutes and then 1,2-dimethoxybenzene (5.0 g, 36.19 mmol) was added. The reaction mixture was continued to be stirred at room temperature for 2.5 h. The reaction mixture was then cooled to -78 °C and a solution of anhydrous hexane (10 mL) with bromine (Br2, 1.85 mL, 36.19 mmol, 1.0 equiv) was added dropwise. The reaction was kept at -78 °C for 30 min, after which it was slowly warmed to room temperature. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium sulfite (Na2SO3, 20 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 3 × 30 mL), the organic layers were combined and washed sequentially with water and brine, dried with anhydrous sodium sulfite (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (9.5:0.5 to 9:1) to afford 1-bromo-2,3-dimethoxybenzene (6.68 g, 85% yield) as a colorless oil.
References
[1] Tetrahedron Asymmetry, 2013, vol. 24, # 24, p. 1548 - 1555
[2] Patent: WO2009/27679, 2009, A1. Location in patent: Page/Page column 51-52
[3] Journal of Organic Chemistry, 1982, vol. 47, # 12, p. 2393 - 2396
1-Bromo-2,3-dimethoxybenzene Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4905 | 55 |
View Latest Price from 1-Bromo-2,3-dimethoxybenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 1-Bromo-2,3-dimethoxybenzene
5424-43-1
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-12 | 1-Bromo-2,3-dimethoxybenzene
5424-43-1
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 1-Bromo-2,3-dimethoxybenzene
5424-43-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-Bromo-2,3-dimethoxybenzene
5424-43-1
- $1.00
- 99%
- Career Henan Chemical Co
