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ChemicalBook >> CAS DataBase List >>L-759,633

L-759,633

L-759,633 Structure
L-759,633 structure
CAS No.
174627-50-0
Chemical Name:
L-759,633
Synonyms
L-759;L 759;L-759,633;L759633,L-759633;(6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene;(6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran;6H-Dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6aR,10aR)-
CBNumber:
CB6837204
Molecular Formula:
C26H40O2
Molecular Weight:
384.59
MDL Number:
MFCD05662266
MOL File:
174627-50-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:27:35
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L-759,633 Properties

Boiling point 447.9±45.0 °C(Predicted)
Density 0.956±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Ethanol:20.0(Max Conc. mg/mL);52.0(Max Conc. mM)
PBS (pH 7.2):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)
form Liquid
color Colorless to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

L-759,633 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009280 L-759,633 ≥98% 174627-50-0 1mg $35 2026-04-30 Buy
Cayman Chemical 10009280 L-759,633 ≥98% 174627-50-0 5mg $147 2026-04-30 Buy
Cayman Chemical 10009280 L-759,633 ≥98% 174627-50-0 10mg $258 2026-04-30 Buy
Cayman Chemical 10009280 L-759,633 ≥98% 174627-50-0 25mg $561 2026-04-30 Buy
American Custom Chemicals Corporation API0006768 L-759633 95.00% 174627-50-0 1MG $568.79 2021-12-16 Buy
Product number Packaging Price Buy
10009280 1mg $35 Buy
10009280 5mg $147 Buy
10009280 10mg $258 Buy
10009280 25mg $561 Buy
API0006768 1MG $568.79 Buy

L-759,633 Chemical Properties, Uses, Production

Description

L-759,633 is a high-affinity peripheral cannabinoid receptor (CB2)-selective agonist with Ki values of 6.4 and 1,043 nM for CB2 and central cannabinoid (CB1) receptors, respectively. L-759,633 inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB2 or CB1 receptors with IC50 values of 8.1 nM and 10 μM, respectively.

Uses

L 759633 is a cannabinoid receptor (CB2) selective agonist and a structural analogues of 9-Tetrahydro Cannabinol, an active constituent of cannabis. L 759633 has analgesic and anti-inflammatory properties.

Definition

ChEBI: 6h-dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6ar,10ar)- is a 1-benzopyran.

Biological Activity

High affinity, selective CB 2 receptor agonist (K i values are 6.4 and 1043 nM for CB 2 and CB 1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB 2 receptors expressed in CHO cells (EC 50 = 8.1 nM).

IC 50

CB2: 6.4 nM (Ki); CB1: 1043 nM (Ki)

References

[1] RUTH A ROSS. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630[J]. British Journal of Pharmacology, 2009, 126 3: 665-672. DOI: 10.1038/sj.bjp.0702351

L-759,633 Preparation Products And Raw materials

Raw materials

Preparation Products

L-759,633 Suppliers

Global Suppliers ( 37)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
EMMX Biotechnology LLC 60
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

174627-50-0 (L-759,633) Related Search:

(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran 1-(1 1-Dimethylheptyl)-3 5-dimethoxyben& 4-(2-Ethoxyphenyl)-2-methyl-1-butene 5-(1,1-Dimethyl-heptyl)resorcinol DELTA-8-THC
L-759,633 ethyl-delta-8-tetrahydrocannabinol

1of2

L-759,633 (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran (6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene 6H-Dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6aR,10aR)- L 759 L-759 L759633,L-759633 174627-50-0 C26H40O2 Cannabinoid receptor