| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
|
| | L-759,633 Basic information |
| Product Name: | L-759,633 | | Synonyms: | L-759,633;(6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran;(6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene;6H-Dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6aR,10aR)-;L 759;L-759;L759633,L-759633 | | CAS: | 174627-50-0 | | MF: | C26H40O2 | | MW: | 384.59 | | EINECS: | | | Product Categories: | Cannabinoid receptor | | Mol File: | 174627-50-0.mol |  |
| | L-759,633 Chemical Properties |
| Boiling point | 447.9±45.0 °C(Predicted) | | density | 0.956±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | Ethanol:20.0(Max Conc. mg/mL);52.0(Max Conc. mM)
PBS (pH 7.2):0.25(Max Conc. mg/mL);0.65(Max Conc. mM) | | form | Liquid | | color | Colorless to light yellow |
| | L-759,633 Usage And Synthesis |
| Description | L-759,633 is a high-affinity peripheral cannabinoid receptor (CB2)-selective agonist with Ki values of 6.4 and 1,043 nM for CB2 and central cannabinoid (CB1) receptors, respectively. L-759,633 inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB2 or CB1 receptors with IC50 values of 8.1 nM and 10 μM, respectively. | | Uses | L 759633 is a cannabinoid receptor (CB2) selective agonist and a structural analogues of 9-Tetrahydro Cannabinol, an active constituent of cannabis. L 759633 has analgesic and anti-inflammatory properties. | | Definition | ChEBI: 6h-dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6ar,10ar)- is a 1-benzopyran. | | Biological Activity | High affinity, selective CB 2 receptor agonist (K i values are 6.4 and 1043 nM for CB 2 and CB 1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB 2 receptors expressed in CHO cells (EC 50 = 8.1 nM). | | IC 50 | CB2: 6.4 nM (Ki); CB1: 1043 nM (Ki) | | References | [1] RUTH A ROSS. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630[J]. British Journal of Pharmacology, 2009, 126 3: 665-672. DOI: 10.1038/sj.bjp.0702351 |
| | L-759,633 Preparation Products And Raw materials |
|