Methyl 2-(4-methylphenylsulfonamido)acetate
- CAS No.
- 2645-02-5
- Chemical Name:
- Methyl 2-(4-methylphenylsulfonamido)acetate
- Synonyms
- T0514-7020;Alkalamide;TsNHCH2COOCH3;methyltosylglycinate;Roxadustat Impurity 26;isopropyl 2-acetyl-4-phenoxybenzoate;N-(Toluene-4-sulfonyl)glycine methyl ester;N-(Toluene-4-sulphonyl)glycine methyl ester;methyl 2-(4-methylphenylsulfonamido)acetate;Methyl N-[(4-methylphenyl)sulfonyl]glycinate
- CBNumber:
- CB6855372
- Molecular Formula:
- C10H13NO4S
- Molecular Weight:
- 243.28
- MDL Number:
- MFCD00558890
- MOL File:
- 2645-02-5.mol
- MSDS File:
- SDS
| Melting point | 89-91°C |
|---|---|
| Boiling point | 372.5±52.0 °C(Predicted) |
| Density | 1.261 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.09±0.50(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C10H13NO4S/c1-8-3-5-9(6-4-8)16(13,14)11-7-10(12)15-2/h3-6,11H,7H2,1-2H3 |
| InChIKey | GYQBPYXMRNEAKZ-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)CNS(C1=CC=C(C)C=C1)(=O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2935909099 |
Methyl 2-(4-methylphenylsulfonamido)acetate price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M339660-5G | Methyl2-(4-methylphenylsulfonamido)acetate | 2645-02-5 | 5g | $70 | 2026-06-03 | Buy |
| TRC | TRC-M339660-1G | Methyl2-(4-methylphenylsulfonamido)acetate | 2645-02-5 | 1g | $59 | 2026-06-03 | Buy |
| TRC | TRC-M339660-10G | Methyl2-(4-methylphenylsulfonamido)acetate | 2645-02-5 | 10g | $91 | 2026-06-03 | Buy |
| AstaTech | CX1370 | (TOLUENE-4-SULFONYLAMINO)-ACETIC ACID METHYL ESTER 99% | 2645-02-5 | 5G | $30 | 2026-04-30 | Buy |
| Apolloscientific | OR61063 | N-(Toluene-4-sulphonyl)glycine methyl ester 98% | 2645-02-5 | 25g | $30 | 2026-06-04 | Buy |
Methyl 2-(4-methylphenylsulfonamido)acetate Chemical Properties,Uses,Production
Synthesis
5680-79-5
98-59-9
2645-02-5
The general experimental procedure was as follows: glycine methyl ester hydrochloride (10 mmol) and sodium carbonate (2.1 g, 20 mmol) were dissolved in anhydrous dichloromethane (50 mL) and cooled in an ice bath. Subsequently, p-toluenesulfonyl chloride (1.9 g, 10 mmol) was added. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, more dichloromethane was added and the organic layer was washed sequentially with 0.1 M hydrochloric acid, saturated sodium bicarbonate solution and brine. The organic phase was dried with anhydrous sodium sulfate and concentrated in vacuum to give the crude product. The crude product was purified by silica gel column chromatography using hexane and ethyl acetate (1:1) as eluent. Methyl 2-(4-methylphenylsulfonylamino)acetate (compound G2) was finally obtained in 78% yield as a white solid.1H NMR (400 MHz, CDCl3): δ 7.74 (d, J = 8.3 Hz, 2H, ArH), 7.31 (d, J = 8.3 Hz, 2H, ArH), 5.04 (t, J = 5.1 Hz, 1H, - NH-), 3.78 (d, J = 5.1 Hz, 2H, -CH2-), 3.64 (s, 3H, -OCH3), 2.42 (s, 3H, -CH3) ppm. 13C NMR (100 MHz, CDCl3): δ 169.4, 144.0, 136.3, 129.9, 127.4, 52.7, 44.2, 21.7 ppm. 21.7 ppm.Calculated elemental values [C10H13NO4S]: C, 49.37; H, 5.39; N, 5.76; S, 13.18.Measured values: C, 50.63; H, 5.09; N, 5.36; S, 12.87.
References
[1] Organic Letters, 2005, vol. 7, # 25, p. 5717 - 5719
[2] ChemMedChem, 2011, vol. 6, # 8, p. 1459 - 1470
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 18, p. 7190 - 7200
[4] Tetrahedron, 2008, vol. 64, # 52, p. 11884 - 11895
[5] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 9, p. 982 - 986
Methyl 2-(4-methylphenylsulfonamido)acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dali Biotechnology Co. , Ltd. | 15705632007 | 3383822427@qq.com | China | 392 | 58 |
| Suzhou Daolan Biomedical Technology Co., Ltd. | 15952404857 | sales@dolanpharm.com | China | 2967 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Lastest Price from Methyl 2-(4-methylphenylsulfonamido)acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-03-21 | Methyl 2-(4-methylphenylsulfonamido)acetate
2645-02-5
|
99% | 1000KGS | Zhengzhou Anbu Chem Co.,Ltd | |||
 |
2019-07-06 | Methyl 2-(4-methylphenylsulfonamido)acetate
2645-02-5
|
$100.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Methyl 2-(4-methylphenylsulfonamido)acetate
2645-02-5
- $0.00
- 99%
- Zhengzhou Anbu Chem Co.,Ltd
-
- Methyl 2-(4-methylphenylsulfonamido)acetate
2645-02-5
- $100.00
- 99%
- Career Henan Chemical Co
2645-02-5(Methyl 2-(4-methylphenylsulfonamido)acetate )Related Search:
1of4
