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ChemicalBook >> CAS DataBase List >>4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Structure
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- structure
CAS No.
1403458-28-5
Chemical Name:
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-
Synonyms
4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-
CBNumber:
CB68844064
Molecular Formula:
C28H29F2N3O5
Molecular Weight:
525.54
MDL Number:
MOL File:
1403458-28-5.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
Request For Quotation

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Properties

Boiling point 721.0±60.0 °C(Predicted)
Density 1.380±0.06 g/cm3(Predicted)
pka 2.35±0.60(Predicted)

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0021620 PI3K-IN-2 99.62% 1403458-28-5 5mg $623 2026-06-04 Buy
ChemScene CS-0021620 PI3K-IN-2 99.62% 1403458-28-5 10mg $1037 2026-06-04 Buy
ChemScene CS-0021620 PI3K-IN-2 99.62% 1403458-28-5 25mg $2177 2026-06-04 Buy
ChemScene CS-0021620 PI3K-IN-2 99.62% 1403458-28-5 50mg $3490 2026-06-04 Buy
ChemScene CS-0021620 PI3K-IN-2 99.62% 1403458-28-5 100mg $5590 2026-06-04 Buy
Product number Packaging Price Buy
CS-0021620 5mg $623 Buy
CS-0021620 10mg $1037 Buy
CS-0021620 25mg $2177 Buy
CS-0021620 50mg $3490 Buy
CS-0021620 100mg $5590 Buy

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Chemical Properties, Uses, Production

Uses

PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively)[1].

in vivo

PI3K-IN-2 shows profound pharmacodynamic modulation of AKT phosphorylation in PTEN-deficient PC3 prostate tumour bearing mice after oral administration and gave significant inhibition of tumour growth in the same xenograft model[1].

IC 50

PI3Kα: 13 nM (IC50); PI3Kβ: 7.1 nM (IC50); PI3Kδ: 190 nM (IC50); PI3Kγ: 8.6 nM (IC50)

References

[1] Barlaam B, et al. Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2017 May 1;27(9):1949-1954. DOI:10.1016/j.bmcl.2017.03.027

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
BOC Sciences 65
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PI3K-IN-2 pictures 2026-04-21 PI3K-IN-2
1403458-28-5
 $2140.00-3520.00 10g TargetMol Chemicals Inc.
  • PI3K-IN-2 pictures
  • PI3K-IN-2
    1403458-28-5
  • $2140.00-3520.00
  • TargetMol Chemicals Inc.

1403458-28-5 (4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)-) Related Search:

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4H-1-Benzopyran-4-one, 8-[(2R)-1-(3,5-difluorophenyl)-2-pyrrolidinyl]-2-(4-morpholinyl)-6-(4-morpholinylcarbonyl)- 1403458-28-5 C28H29F2N3O5