Apigenin-D5
- CAS No.
- 263711-74-6
- Chemical Name:
- Apigenin-D5
- Synonyms
- Apigenin-D5;Apigenin-d5 (Major);Pelargidenon 1449-d5;[3,6,8,35d5]-Apigenin;4',5,7-Trihydroxyflavone-d5;5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5;4H-1-Benzopyran-4-one-3,6,8-d3, 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)-;3,6,8-trideuterio-2-(3,5-dideuterio-4-hydroxyphenyl)-5,7-dihydroxychromen-4-one
- CBNumber:
- CB71121213
- Molecular Formula:
- C15H5D5O5
- Molecular Weight:
- 275.27
- MDL Number:
- MFCD09839941
- MOL File:
- 263711-74-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Apigenin-d5 ≥99%deuteratedforms(d1-d5);≤1%d0 | 22106 | 500μg | $160 |
| Apigenin-d5 ≥99%deuteratedforms(d1-d5);≤1%d0 | 22106 | 1mg | $304 |
| Apigenin-d5 (Major) | 002799 | 1mg | $523 |
| Apigenin-d5 | CS-0084190 | 1mg | $520 |
| Apigenin-d5(Major) | A726502 | 1mg | $145 |
| More product size | |||
| Melting point | 345-350°C |
|---|---|
| Boiling point | 555.505±50.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.548±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| pka | 6.525±0.40(predicted) |
| color | Pale Yellow to Yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Apigenin-D5 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22106 | Apigenin-d5 ≥99%deuteratedforms(d1-d5);≤1%d0 | 263711-74-6 | 500μg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 22106 | Apigenin-d5 ≥99%deuteratedforms(d1-d5);≤1%d0 | 263711-74-6 | 1mg | $304 | 2026-04-30 | Buy |
| Usbiological | 002799 | Apigenin-d5 (Major) | 263711-74-6 | 1mg | $523 | 2026-06-03 | Buy |
| ChemScene | CS-0084190 | Apigenin-d5 | 263711-74-6 | 1mg | $520 | 2026-06-04 | Buy |
| TRC | A726502 | Apigenin-d5(Major) | 263711-74-6 | 1mg | $145 | 2021-12-16 | Buy |
Apigenin-D5 Chemical Properties,Uses,Production
Description
Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.
Chemical Properties
Pale Yellow Crystalline Solid
Uses
The labelled aglucon of apiin and of apigenin-7-glucoside
in vivo
Apigenin (4',5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. Apigenin (125 mg/kg and 250 mg/kg) alleviates Adriamycin (ADR) (24 mg/kg)-induced myocardial injury. Apigenin inhibits serum aspartate amino transferase (AST) release. Apigenin reduces serum lactate dehydrogenase (LDH) release. Apigenin reduces serum creatine kinase (CK) contents[4].
References
[1] MASATERU YAMADA. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 21: 7736-7741. DOI: 10.1073/pnas.0409818102
[2] JIAN SHEN. Phosphorylation by the Protein Kinase CK2 Promotes Calpain-Mediated Degradation of IκBα1[J]. The Journal of Immunology, 2001, 25 1: 4919-4925. DOI: 10.4049/jimmunol.167.9.4919
[3] GIUSEPPINA MATTACE RASO. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1[J]. Life sciences, 2001, 68 8: Pages 921-931. DOI: 10.1016/s0024-3205(00)00999-1
Apigenin-D5 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 18794 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
