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BOC-N-Methyl-L-alanine

BOC-N-Methyl-L-alanine structure

CAS No.: 16948-16-6

Chemical Name:: BOC-N-Methyl-L-alanine

Synonyms: BOC-N-ME-ALA-OH;Boc-N-Me-Ala;BOC-MEALA-OH;Boc-Lys(TFA);N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ALANINE;N-[(1,1-DiMethylethoxy)carbonyl]-N-Methyl-L-alanine;Boc-NaL;BOC-L-MEALA-OH;BOC-N-ME-ALANINE;BOC-N-ME-S-ALA-OH

CBNumber:: CB7133215

Molecular Formula:: C9H17NO4

Molecular Weight:: 203.24

MDL Number:: MFCD00037242

MOL File:: 16948-16-6.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
Boc-N-Me-Ala-OH Novabiochem?	8.53082	5G	$403
Boc-N-Me-Ala-OH ≥99.0% (TLC)	15549	1g	$87.5
Boc-N-Me-Ala-OH ≥99.0% (TLC)	15549	5g	$309
N-(tert-Butoxycarbonyl)-N-methyl-L-alanine >98.0%(GC)(T)	B3651	5g	$38
N-(tert-Butoxycarbonyl)-N-methyl-L-alanine >98.0%(GC)(T)	B3651	25g	$94
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BOC-N-Methyl-L-alanine Properties

Melting point	88-92 °C
Boiling point	296.3±19.0 °C(Predicted)
Density	1.111±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	Solid
pka	4.03±0.10(Predicted)
color	White
optical activity	[α]20/D 30±1°, c = 1% in ethanol
BRN	2366513
InChI	InChI=1S/C9H17NO4/c1-6(7(11)12)10(5)8(13)14-9(2,3)4/h6H,1-5H3,(H,11,12)/t6-/m0/s1
InChIKey	VLHQXRIIQSTJCQ-LURJTMIESA-N
SMILES	C(O)(=O)[C@H](C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference	16948-16-6(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Safety Statements

24/25

WGK Germany

HS Code

2924 19 00

HazardClass

IRRITANT

NFPA 704

	1
2		0

BOC-N-Methyl-L-alanine price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53082	Boc-N-Me-Ala-OH Novabiochem?	16948-16-6	5G	$403	2025-07-31	Buy
Sigma-Aldrich	15549	Boc-N-Me-Ala-OH ≥99.0% (TLC)	16948-16-6	1g	$87.5	2025-07-31	Buy
Sigma-Aldrich	15549	Boc-N-Me-Ala-OH ≥99.0% (TLC)	16948-16-6	5g	$309	2024-03-01	Buy
TCI Chemical	B3651	N-(tert-Butoxycarbonyl)-N-methyl-L-alanine >98.0%(GC)(T)	16948-16-6	5g	$38	2025-07-31	Buy
TCI Chemical	B3651	N-(tert-Butoxycarbonyl)-N-methyl-L-alanine >98.0%(GC)(T)	16948-16-6	25g	$94	2025-07-31	Buy

Product number	Packaging	Price	Buy
8.53082	5G	$403	Buy
15549	1g	$87.5	Buy
15549	5g	$309	Buy
B3651	5g	$38	Buy
B3651	25g	$94	Buy

BOC-N-Methyl-L-alanine Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Boc-N-methyl-L-alanine can be used in peptide synthesis.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

15761-38-3

74-88-4

16948-16-6

General method: (S)-2-(tert-butoxycarbonylamino)-3-hydroxypropanoic acid (1 eq.) and iodomethane (10 eq.) were dissolved in anhydrous THF under nitrogen protection and cooled to 0 °C. Pure sodium hydride (10 eq.) was added in batches over 2.0 h. The reaction mixture was kept stirred at 0°C. Subsequently, the reaction mixture was continued to be stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was diluted with ether (20 mL) and quenched with water (30 mL). The organic layer was separated and the aqueous layer was extracted with ether (2 x 15 mL). The combined organic layers were adjusted to pH 3 with aqueous citric acid and then extracted with EtOAc (3 x 20 mL). The combined EtOAc extracts were dried with anhydrous Na2SO4 and concentrated under reduced pressure to give BOC-N-methyl-L-alanine in 90% yield as a colorless oil.

References

[1] Tetrahedron, 2006, vol. 62, # 2-3, p. 264 - 284
[2] Chemistry - A European Journal, 2013, vol. 19, # 32, p. 10619 - 10624
[3] British Journal of Pharmacology, 2016, p. 2657 - 2668
[4] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1148 - 1162
[5] Canadian Journal of Chemistry, 1977, vol. 55, p. 906 - 910

BOC-N-Methyl-L-alanine Preparation Products And Raw materials

Raw materials

N-(tert-Butoxycarbonyl)-L-alanine Iodomethane Sodium hydride Tetrahydrofuran

Preparation Products

(S)-3,4-Dimethyloxazolidine-2,5-dione

BOC-N-Methyl-L-alanine Suppliers

Global( 365)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1014	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2557	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58
Shanghai Longyu Biotechnology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from BOC-N-Methyl-L-alanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-20	BOC-N-Methyl-L-alanine 16948-16-6	US $0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-07-08	Boc-N-methyl-L-alanine 16948-16-6	US $0.00 / Box	1Box	99%	200kg	Hangzhou ICH Biofarm Co., Ltd
2019-07-06	BOC-N-Methyl-L-alanine 16948-16-6	US $7.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

BOC-N-Methyl-L-alanine
16948-16-6
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-N-methyl-L-alanine
16948-16-6
US $0.00 / Box
99%
Hangzhou ICH Biofarm Co., Ltd

BOC-N-Methyl-L-alanine
16948-16-6
US $7.00 / kg
99%
Career Henan Chemical Co

BOC-N-Methyl-L-alanine Spectrum

BOC-N-Methyl-L-alanine(16948-16-6)¹HNMR

16948-16-6(BOC-N-Methyl-L-alanine)Related Search:

Phenprobamate N-Methyl-L-alanine L-Alanine Bensulfuron methyl D-Alanine

Kresoxim-methyl N-(tert-Butoxycarbonyl)-L-alanine Methyl salicylate EC 2.6.1.2 Boc-Aib-OH

tert-Butyldimethylsilyl chloride TRIMETHYLPHOSPHINE OXIDE N-Boc-L-valine METSULFURON METHYL Methylparaben

Fmoc-Lys(Boc)-OH Thiophanate-methyl BOC-L-Serine

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BOC-L-MEALA-OH BOC-N-ALPHA-METHYL-L-ALANINE BOC-MEALA-OH BOC-N-ME-ALANINE BOC-N-ME-ALA-OH BOC-N-ME-S-ALA-OH BOC-N-METHYL-L-ALANINE BOC-N-METHYL-L-ALA-OH N-ALPHA-T-BOC-N-ALPHA-METHYL-L-ALANINE N-ALPHA-T-BUTYLOXYCARBONYL-N-METHYL-L-ALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ALANINE N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-ALANINE 2-(tert-Butoxycarbonyl-methyl-amino)-propionic acid Boc-N-Me-L-Ala-Oh Boc-N-Me-Ala-OH Boc-N-methyl-alanine N-tert-Butoxycarbonyl-N-methyl-L-alanine Boc-N-methyl-L-alanine ,98% Boc-N-methyl-Alanine N-[(1,1-DiMethylethoxy)carbonyl]-N-Methyl-L-alanine N-Methyl- N-(tert-butyloxycarbonyl)alanine N-tert-Butoxycarbonyl-N-Methylalanine N-Boc-N-methyl-L-alanine Boc-N-Me-Ala-OH N-BOC-N-METHYL-L-ALANINE (2S)-2-[(tert-butoxycarbonyl)(Methyl)aMino]propanoic acid (S)-2-(tert-Butoxycarbonyl-Methyl-aMino)-propionic acid Boc-Lys(TFA) Boc-N-Me-Ala Boc-Nalpha-Methyl-L-alanine, 95+% Boc-N-methyl-L-alanine≥ 99% (HPLC, Chiral purity) (Tert-Butoxy)Carbonyl N-Me-Ala-OH N-(tert-Butoxycarbonyl)-N-methyl-L-alanine > Boc-NaL L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- BOC-N-Methyl-L-alanine USP/EP/BP (2S)-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoic acid Boc-N-a-methyl-L-alanine Boc-N-α-Methyl-L-alanine Boc-N-Me-Ala-OH 16948-16-6 Specialty Synthesis Unnatural Amino Acid Derivatives Peptide Synthesis N-Methyl Amino Acids Pyrazoles Boc-Amino acid series Amino Acids & Derivatives Chiral Reagents amino acids Alanine [Ala, A] N-Methyl Amino Acids