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NVS MLLT-1

NVS MLLT-1 Structure
NVS MLLT-1 structure
CAS No.
2561471-13-2
Chemical Name:
NVS MLLT-1
Synonyms
NVS MLLT-1;6-Isoquinolinecarboxamide, N-[2-[[(2S)-2-methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-
CBNumber:
CB713898484
Molecular Formula:
C23H23N5O
Molecular Weight:
385.46
MDL Number:
MOL File:
2561471-13-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:33
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NVS MLLT-1 Properties

Boiling point 586.910±35.00 °C(Press: 760.00 Torr)(predicted)
Density 1.329±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear
form powder
pka 11.028±0.10(predicted)
color white to beige
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

NVS MLLT-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 41318 NVS-MLLT-1 ≥98% 2561471-13-2 1mg $29 2026-04-30 Buy
Cayman Chemical 41318 NVS-MLLT-1 ≥98% 2561471-13-2 5mg $115 2026-04-30 Buy
Cayman Chemical 41318 NVS-MLLT-1 ≥98% 2561471-13-2 10mg $158 2026-04-30 Buy
ChemScene CS-0928502 NVS MLLT-1 99.79% 2561471-13-2 1mg $87 2026-06-04 Buy
ChemScene CS-0928502 NVS MLLT-1 99.79% 2561471-13-2 5mg $271 2026-06-04 Buy
Product number Packaging Price Buy
41318 1mg $29 Buy
41318 5mg $115 Buy
41318 10mg $158 Buy
CS-0928502 1mg $87 Buy
CS-0928502 5mg $271 Buy

NVS MLLT-1 Chemical Properties, Uses, Production

Uses

NVS MLLT-1 (compound 3) is a potent and selective MLLT1 inhibitor with Kd values of 0.18 μM, 0.24 μM, and 0.22 μM for wild-type, T1 mutants, and T3 mutants, respectively[1][2].

Biological Activity

NVP-MLLT-1 is a potent and selective inhibitor against YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3).

References

[1] Ni X, et al. Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. ACS Chem Biol. 2021 Apr 16;16(4):571-578. DOI:10.1021/acschembio.0c00960
[2] Lee J, et al. The Promise and Peril of Chemical Probe Negative Controls. ACS Chem Biol. 2021 Apr 16;16(4):579-585. DOI:10.1021/acschembio.1c00036

NVS MLLT-1 Preparation Products And Raw materials

Raw materials

Preparation Products

NVS MLLT-1 Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
Guangzhou Younan Technology Co., Ltd 020-82000279 18988941452 YN_research@163.com China 2984 58
Supplier Advantage
Guangzhou Younan Technology Co., Ltd 58

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NVS MLLT-1 6-Isoquinolinecarboxamide, N-[2-[[(2S)-2-methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]- 2561471-13-2