GLS1 Inhibitor-4
- CAS No.
- 2768599-97-7
- Chemical Name:
- GLS1 Inhibitor-4
- Synonyms
- GLS1 Inhibitor-4;1H-Imidazole-2-carboxamide, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-1-[[4-(trifluoromethyl)phenyl]methyl]-
- CBNumber:
- CB714061601
- Molecular Formula:
- C29H27F3N10O2S2
- Molecular Weight:
- 668.72
- MDL Number:
- MOL File:
- 2768599-97-7.mol
- MSDS File:
- SDS
GLS1 Inhibitor-4 Chemical Properties, Uses, Production
Uses
GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM. GLS1 Inhibitor-4 shows antiproliferative activity, good metabolic stability, robust GLS1 binding affinity. GLS1 Inhibitor-4 blocks the glutamine metabolism and induce the production of ROS. GLS1 Inhibitor-4 induces apoptosis and shows antitumor activity[1].
in vivo
GLS1 Inhibitor-4 (50, 100 mg/kg; i.p.; twice a day for 21 consecutive days) shows antitumor activity in a dose-dependent manne[1].
| Animal Model: | Six-week-old BALB/c SPF nude mice (HCT116 tumor nude mouse xenograft model)[1] |
| Dosage: | 50, 100 mg/kg |
| Administration: | I.p.; twice a day for 21 consecutive days |
| Result: | Inhibited the tumor growth at a dose-dependent manne with the tumor growth inhibition (TGI) values of 35.5% at 50 mg/kg and 47.5% at 100 mg/kg, respectively. |
References
[1] Xu X, et al. Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles. Eur J Med Chem. 2022 Jun 5;236:114337. DOI:10.1016/j.ejmech.2022.114337
GLS1 Inhibitor-4 Preparation Products And Raw materials
Raw materials
Preparation Products
GLS1 Inhibitor-4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from GLS1 Inhibitor-4 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | GLS1 Inhibitor-4
2768599-97-7
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- GLS1 Inhibitor-4
2768599-97-7
- $1520.00-2500.00
- TargetMol Chemicals Inc.
