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ChemicalBook >> CAS DataBase List >>3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Structure
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro structure
CAS No.
878671-96-6
Chemical Name:
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro
Synonyms
5-amino-4 -(4-cyclopropyl-1-naphthalene)-2, 4-dihydro-3H-1,2, 4-thiazole-3-mercaptan;2,3-Butanedione,4-bromo-;3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-napht...;3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol;3-Amino-4-(4-cyclopropyl-1-naphthyl)-1H-1,2,4-triazole-5(4H)-thione;3-amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5-thione;5-AMINO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-2H-1,2,4-TRIAZOLE-3-THIONE;3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione;3-amino-4 - (4-cyclopropylnaphthalene - 1-yl) -1H-1,2, 4-triazole-5-thione;3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-phthalenyl)-2,4-dihydro
CBNumber:
CB71465755
Molecular Formula:
C15H14N4S
Molecular Weight:
282.36
MDL Number:
MFCD09991698
MOL File:
878671-96-6.mol
MSDS File:
SDS
Last updated:2026-05-28 02:53:23
Request For Quotation

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Properties

Boiling point 475.2±38.0 °C(Predicted)
Density 1.52±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 8.22±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 434925 5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol 878671-96-6 1g $312 2026-06-03 Buy
Usbiological 434925 5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol 878671-96-6 5g $502 2026-06-03 Buy
aablocks AA0039NB 3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol ≥99% 878671-96-6 50mg $67 2026-05-28 Buy
aablocks AA0039NB 3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol 97% 878671-96-6 100mg $111 2026-05-28 Buy
aablocks AA0039NB 3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol 97% 878671-96-6 1g $184 2026-05-28 Buy
Product number Packaging Price Buy
434925 1g $312 Buy
434925 5g $502 Buy
AA0039NB 50mg $67 Buy
AA0039NB 100mg $111 Buy
AA0039NB 1g $184 Buy

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Chemical Properties, Uses, Production

Uses

5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol is a derivative of 5-Amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-Triazol-3-one (A602165), which is an impurity of the drug Lesinuard (L329700), which is used to synthesize febuxostat, a non-purine analog inhibitor of xanthine oxidase. Febuxostat is approved by the European Medicines Agency and the US Food and Drug Administration for treating gout.

Synthesis

NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATO-

878671-95-5

AMINOGUANIDINE HYDROCHLORIDE

1937-19-5

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro

878671-96-6

1-Cyclopropyl-4-isothiocyanato naphthalene (13.3 mmol, 3.0 g) and aminoguanidine hydrochloride (26.6 mmol, 2.9 g) were mixed in 50 mL of N,N-dimethylformamide. N,N-diisopropylethylamine (39.9 mmol, 5.1 g) was slowly added under stirring conditions. The reaction mixture was stirred at room temperature for 50±12 hrs. After completion of the reaction, the solvent was removed to dryness by rotary evaporator. To the residue, 20 mL of 2 M sodium hydroxide solution was added and the reaction was continued for 50 ± 12 hours. After termination of the reaction, the reaction mixture was filtered and the filtrate was adjusted to pH=4 with dilute hydrochloric acid, at which time a large amount of white precipitate was observed to be generated. The precipitate was collected, washed with deionized water and subsequently dried under vacuum at 45-50 °C to afford the intermediate compound 5-amino-4-(4-cyclopropyl-1-naphthalene)-2,4-dihydro-3H-1,2,4-triazole-3-thiol (VI) in 2.85 g yield and 76% yield.

References

[1] Patent: CN105566237, 2016, A. Location in patent: Paragraph 0066; 0067; 0068
[2] Patent: WO2009/70740, 2009, A2. Location in patent: Page/Page column 89-90
[3] Patent: WO2006/26356, 2006, A2. Location in patent: Page/Page column 21
[4] Patent: WO2011/85009, 2011, A2. Location in patent: Page/Page column 37

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Preparation Products And Raw materials

Raw materials

Naphthalene, 1-cyclopropyl-4-isothiocyanato- Aminoguanidine hydrochloride N,N-Diisopropylethylamine N,N-Dimethylformamide

Preparation Products

3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro Suppliers

Global Suppliers ( 134)
Supplier Tel Email Country ProdList Advantage
nanjing 13376084917 13376082704 3930959291@qq.com China 2056 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Jiangsu Vcare PharmaTech Co., Ltd. 025-58741518 13327700685 sales@vcarepharmatech.com China 281 61
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 21-33585366 13311639313 sales@shyrchem.com China 807 55
AstaTech (Chengdu) Pharma. Co., Ltd. 15928766785 15928766785 wupengcheng@astatech.cn China 1997 55
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Shanghai SE Pharm Co., Ltd 18112588827 sales4@sepharm.com.cn China 285 60
Supplier Advantage
nanjing 58
J & K SCIENTIFIC LTD. 76
Jiangsu Vcare PharmaTech Co., Ltd. 61
Hangzhou Sage Chemical Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
Nanjing Norris-Pharm Technology Co., Ltd 55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 55
AstaTech (Chengdu) Pharma. Co., Ltd. 55
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Shanghai SE Pharm Co., Ltd 60

View Latest Price from 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro pictures 2025-04-04 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro
878671-96-6
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro pictures 2021-07-13 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro
878671-96-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro pictures 2021-07-10 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro
878671-96-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

878671-96-6 (3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro) Related Search:

Lesinurad Impurity J 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Lesinurad Impurity 5 Sodium Salt 3-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide
lesinurad int RDEA 594 Lesinurad Impurity 38 Lesinurad Impurity 32 (Mixture of Isomers) Lesinurad Impurity H
Lesinurad Impurity 24 Lesinurad Impurity N Lesinurad Impurity 27 Lesinurad Impurity 22 Lesinurad Impurity 10
1-cyclopropylnaphthalene Lesinurad Impurity 4 Lesinurad Impurity 23

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3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro-3H-1,2,4-Triazole-3-thione 3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-5-thiol 3-Amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-phthalenyl)-2,4-dihydro 5-amino-4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 3-amino-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5-thione 3-Amino-4-(4-cyclopropyl-1-naphthyl)-1H-1,2,4-triazole-5(4H)-thione 3-amino-4 - (4-cyclopropylnaphthalene - 1-yl) -1H-1,2, 4-triazole-5-thione 3H-1,2,4-TRIAZOLE-3-THIONE,5-AMINO-4-(4-CYCLOPROPYL-1- NAPHTHALENYL)-2,4-DIHYDRO LESINURAD INTERMEDIATE 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-napht... 2,3-Butanedione,4-bromo- 5-AMINO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-2H-1,2,4-TRIAZOLE-3-THIONE 5-amino-4 -(4-cyclopropyl-1-naphthalene)-2, 4-dihydro-3H-1,2, 4-thiazole-3-mercaptan 878671-96-6 878971-96-6 Drug Intermediates