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5-Bromo-2-methyl-3-nitropyridine

5-Bromo-2-methyl-3-nitropyridine structure

CAS No.: 911434-05-4

Chemical Name:: 5-Bromo-2-methyl-3-nitropyridine

Synonyms: 5-broMo-2-Methyl-3-n;5-Bromo-3-nitropicoline;5-Bromo-3-nitro-2-picoline;5-Bromo-2-methyl-3-nitrop...;5-bromo-2-methy-3-nitropyridine;5-Bromo-2-methyl-3-nitropyridine;5-Bromo-2-methy1-3-nitropyridine;2-methyl-3-nitro-5-bromo pyridine;Pyridine,5-broMo-2-Methyl-3-nitro-;5-Bromo-2-methyl-3-nitropyridine >

CBNumber:: CB71471280

Molecular Formula:: C6H5BrN2O2

Molecular Weight:: 217.02

MDL Number:: MFCD09031419

MOL File:: 911434-05-4.mol

MSDS File:: SDS

Last updated:2026-05-28 02:17:50

Product description	Number	Pack Size	Price
5-Bromo-2-methyl-3-nitropyridine >98.0%(GC)	B4070	1g	$19
5-Bromo-2-methyl-3-nitropyridine >98.0%(GC)	B4070	5g	$54
5-Bromo-2-methyl-3-nitropyridine	233970	1g	$215
5-Bromo-2-methyl-3-nitropyridine	233970	5g	$472
5-Bromo-2-methyl-3-nitropyridine >97%	OR42176	5g	$21
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5-Bromo-2-methyl-3-nitropyridine Properties

Melting point	38.0 to 42.0 °C
Boiling point	253 °C
Density	1.709
Flash point	107 °C
storage temp.	Inert atmosphere,Room Temperature
pka	-0.44±0.20(Predicted)
form	powder to crystal
color	Light yellow to Amber to Dark green
InChI	InChI=1S/C6H5BrN2O2/c1-4-6(9(10)11)2-5(7)3-8-4/h2-3H,1H3
InChIKey	FZZLWWNOYMHSIS-UHFFFAOYSA-N
SMILES	C1(C)=NC=C(Br)C=C1[N+]([O-])=O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H315-H319-H302

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

HS Code

2933399990

NFPA 704

	1
2		0

5-Bromo-2-methyl-3-nitropyridine price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B4070	5-Bromo-2-methyl-3-nitropyridine >98.0%(GC)	911434-05-4	1g	$19	2026-04-30	Buy
TCI Chemical	B4070	5-Bromo-2-methyl-3-nitropyridine >98.0%(GC)	911434-05-4	5g	$54	2026-04-30	Buy
Usbiological	233970	5-Bromo-2-methyl-3-nitropyridine	911434-05-4	1g	$215	2026-06-03	Buy
Usbiological	233970	5-Bromo-2-methyl-3-nitropyridine	911434-05-4	5g	$472	2026-06-03	Buy
Apolloscientific	OR42176	5-Bromo-2-methyl-3-nitropyridine >97%	911434-05-4	5g	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
B4070	1g	$19	Buy
B4070	5g	$54	Buy
233970	1g	$215	Buy
233970	5g	$472	Buy
OR42176	5g	$21	Buy

5-Bromo-2-methyl-3-nitropyridine Chemical Properties,Uses,Production

Uses

5-Bromo-2-methyl-3-nitropyridine is used as a reactant in the synthesis of MLN0905, a potent and orally bioavailable inhibitor of Polo-like kinase 1 (PLK1).

Synthesis

2-(5-BROMO-3-NITROPYRIDIN-2-YL)MALONIC ACID DIETHYL ESTER

911434-04-3

911434-05-4

Step 2 - Synthesis of 5-bromo-2-methyl-3-nitropyridine Diethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate (1.2 g, 3.3 mmol) was dissolved in 7.0 N HCl (10 mL). The mixture was heated to reflux for 5 hours. After completion of the reaction, it was cooled to room temperature and extracted with dichloromethane: methanol (10:1, v/v). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by column chromatography using petroleum ether: ethyl acetate (4:1, v/v) as eluent to afford 5-bromo-2-methyl-3-nitropyridine (0.7 g, yield: 89.7%). 1H-NMR (CDCl3, 400 MHz) δ 8.76 (s, 1H), 8.40 (s, 1H), 2.80 (s, 3H).

References

[1] Patent: US2008/194552, 2008, A1. Location in patent: Page/Page column 40
[2] Patent: WO2010/68292, 2010, A1. Location in patent: Page/Page column 78
[3] Patent: WO2013/33899, 2013, A1. Location in patent: Page/Page column 39
[4] Patent: WO2013/34048, 2013, A1. Location in patent: Page/Page column 46; 47
[5] Patent: WO2012/88411, 2012, A1. Location in patent: Page/Page column 64

5-Bromo-2-methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

5-Bromo-2-chloro-3-nitropyridine 2-(5-BROMO-3-NITROPYRIDIN-2-YL)MALONIC ACID DIETHYL ESTER Diethyl malonate

Preparation Products

5-BROMO-2-METHYLPYRIDIN-3-AMINE

5-Bromo-2-methyl-3-nitropyridine Suppliers

Global( 281)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14036	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3969	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	+8618062405514	ada@ipurechemical.com	China	10224	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hefei Hangang Pharmaceutical Technology Co., Ltd.	58

View Lastest Price from 5-Bromo-2-methyl-3-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-17	5-Bromo-2-methyl-3-nitropyridine 911434-05-4	$6.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-06-30	5-Bromo-2-methyl-3-nitropyridine 911434-05-4		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-02-02	5-Bromo-2-methyl-3-nitropyridine 911434-05-4	$1.00	1g	98%	50tons	Shaanxi Dideu Medichem Co. Ltd

5-Bromo-2-methyl-3-nitropyridine
911434-05-4
$6.00
98%
Henan Fengda Chemical Co., Ltd

5-Bromo-2-methyl-3-nitropyridine
911434-05-4
98.0%
Shaanxi Dideu New Materials Co. Ltd

5-Bromo-2-methyl-3-nitropyridine
911434-05-4
$1.00
98%
Shaanxi Dideu Medichem Co. Ltd

5-Bromo-2-methyl-3-nitropyridine Spectrum

5-Bromo-2-methyl-3-nitropyridine(911434-05-4)¹HNMR

911434-05-4(5-Bromo-2-methyl-3-nitropyridine)Related Search:

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5-Bromo-3-nitropyridine-2-carbonitrile 5-Bromo-2-methyl-3-nitropyridine 2-Methyl-3-nitropyridine 3-BROMO-2-CHLORO-5-NITRO-6-PICOLINE 2-Amino-3-bromo-6-methyl-5-nitropyridine

3-BROMO-2,6-DIMETHYL-5-NITROPYRIDIN-4-OL 5-BROMO-3-NITROPYRIDINE-2-CARBOXYLIC ACID 3-BROMO-2-HYDROXY-5-NITRO-6-PICOLINE (5-BROMO-3-NITRO-PYRIDIN-2-YL)-ACETONITRILE N-(5-bromo-2-(ethoxy(imino)methyl)pyridin-3-yl)-N-oxohydroxylammonium

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5-Bromo-2-methyl-3-nitropyridine 5-Bromo-3-nitropicoline 5-Bromo-2-methyl-3-nitrop... 5-Bromo-3-nitro-2-picoline 5-broMo-2-Methyl-3-n Pyridine,5-broMo-2-Methyl-3-nitro- 5-Bromo-2-methyl-3-nitropyridine > 5-Bromo-2-methyl-3-nitropyridine ISO 9001：2015 REACH 5-bromo-2-methy-3-nitropyridine 2-methyl-3-nitro-5-bromo pyridine 5-Bromo-2-methy1-3-nitropyridine 911434-05-4 Heterocycle-Pyridine series