2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid
- CAS No.
- 128694-63-3
- Chemical Name:
- 2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid
- Synonyms
- EU-0083300;ZERO/005391;MLS000850704;SMR000456721;TimTec1_003188;2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid;2-methyl-5-(trifluoromethyl)-3-pyrazolecarboxylic acid;Pyrazole-5-carboxylic acid, 3-trifluorromethyl-1-methyl-;1-Methyl-3-(trifluoromethy)-2H-pyrazole-5-caboxylic Acid;2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid
- CBNumber:
- CB71501950
- Molecular Formula:
- C6H5F3N2O2
- Molecular Weight:
- 194.11
- MDL Number:
- MFCD02090853
- MOL File:
- 128694-63-3.mol
- MSDS File:
- SDS
| Melting point | 131-133℃ |
|---|---|
| Boiling point | 288.8±40.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | crystalline powder |
| pka | 2.55±0.25(Predicted) |
| color | White |
| InChI | InChI=1S/C6H5F3N2O2/c1-11-3(5(12)13)2-4(10-11)6(7,8)9/h2H,1H3,(H,12,13) |
| InChIKey | AQUQLOWJSBFHBD-UHFFFAOYSA-N |
| SMILES | N1(C)C(C(O)=O)=CC(C(F)(F)F)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| HazardClass | IRRITANT |
| HS Code | 29331990 |
2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC520519 | 2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98% | 128694-63-3 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC520519 | 2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98% | 128694-63-3 | 1g | $59 | 2026-06-04 | Buy |
| Apolloscientific | PC520519 | 2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98% | 128694-63-3 | 5g | $281 | 2026-06-04 | Buy |
| Apolloscientific | PC520519 | 2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98% | 128694-63-3 | 25g | $1053 | 2026-06-04 | Buy |
| Matrix Scientific | 291897 | 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid | 128694-63-3 | 1.00g | $68 | 2026-05-19 | Buy |
2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid is used in preparation of arylaminopyridine carboxamides as vanin inhibitors for treatment of vanin-mediated diseases.
Synthesis
1236144-18-5
128694-63-3
General procedure for the synthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid from ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate: To a 15 mL Schlenk reaction flask containing ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate (1.5 mmol) was added a solution of 1 N sodium hydroxide (2.5 mL), the The resulting mixture was stirred vigorously for 24 h at room temperature. Upon completion of the reaction, the reaction mixture was acidified with 6 N HCl at 0 °C. The resulting solid was collected by filtration and the solid was suspended in dichloromethane. The organic and aqueous layers were separated and the aqueous layer was further extracted with dichloromethane. All organic layers were combined and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent ratio: hexane/EtOAc = 5:1 to 2:1) to afford 1-methyl-3-trifluoromethyl-5-pyrazolecarboxylic acid (275 mg, 95% yield) as a white solid.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 46, p. 4344 - 4347
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 24, p. 6255 - 6258
2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
View Latest Price from 2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-01 | 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
128694-63-3
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
128694-63-3
- $1.00
- 99%
- Career Henan Chemical Co
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