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2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID structure

CAS No.: 128694-63-3

Chemical Name:: 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

Synonyms: EU-0083300;ZERO/005391;MLS000850704;SMR000456721;TimTec1_003188;2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid;2-methyl-5-(trifluoromethyl)-3-pyrazolecarboxylic acid;Pyrazole-5-carboxylic acid, 3-trifluorromethyl-1-methyl-;1-Methyl-3-(trifluoromethy)-2H-pyrazole-5-caboxylic Acid;2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

CBNumber:: CB71501950

Molecular Formula:: C6H5F3N2O2

Molecular Weight:: 194.11

MDL Number:: MFCD02090853

MOL File:: 128694-63-3.mol

MSDS File:: SDS

Last updated:2026-05-28 02:42:13

Product description	Number	Pack Size	Price
2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	PC520519	250mg	$21
2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	PC520519	1g	$59
2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	PC520519	5g	$281
2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	PC520519	25g	$1053
2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	PC520519	250mg	$21
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2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Properties

Melting point	131-133℃
Boiling point	288.8±40.0 °C(Predicted)
Density	1.56±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	crystalline powder
pka	2.55±0.25(Predicted)
color	White
InChI	InChI=1S/C6H5F3N2O2/c1-11-3(5(12)13)2-4(10-11)6(7,8)9/h2H,1H3,(H,12,13)
InChIKey	AQUQLOWJSBFHBD-UHFFFAOYSA-N
SMILES	N1(C)C(C(O)=O)=CC(C(F)(F)F)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P261-P280-P305+P351+P338
Risk Statements	22-36/37/38
Safety Statements	26-36
HazardClass	IRRITANT
HS Code	29331990

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC520519	2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	128694-63-3	250mg	$21	2026-06-04	Buy
Apolloscientific	PC520519	2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	128694-63-3	1g	$59	2026-06-04	Buy
Apolloscientific	PC520519	2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	128694-63-3	5g	$281	2026-06-04	Buy
Apolloscientific	PC520519	2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	128694-63-3	25g	$1053	2026-06-04	Buy
Apolloscientific	PC520519	2-Methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 98%	128694-63-3	250mg	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
PC520519	250mg	$21	Buy
PC520519	1g	$59	Buy
PC520519	5g	$281	Buy
PC520519	25g	$1053	Buy
PC520519	250mg	$21	Buy

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid is used in preparation of arylaminopyridine carboxamides as vanin inhibitors for treatment of vanin-mediated diseases.

Synthesis

Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate

1236144-18-5

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

128694-63-3

General procedure for the synthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid from ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate: To a 15 mL Schlenk reaction flask containing ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate (1.5 mmol) was added a solution of 1 N sodium hydroxide (2.5 mL), the The resulting mixture was stirred vigorously for 24 h at room temperature. Upon completion of the reaction, the reaction mixture was acidified with 6 N HCl at 0 °C. The resulting solid was collected by filtration and the solid was suspended in dichloromethane. The organic and aqueous layers were separated and the aqueous layer was further extracted with dichloromethane. All organic layers were combined and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent ratio: hexane/EtOAc = 5:1 to 2:1) to afford 1-methyl-3-trifluoromethyl-5-pyrazolecarboxylic acid (275 mg, 95% yield) as a white solid.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 46, p. 4344 - 4347
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 24, p. 6255 - 6258

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate Cobalt acetate Manganese(II) acetate 1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

Preparation Products

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Suppliers

Global( 126)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8741	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5973	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Accela ChemBio Inc.	58
career henan chemical co	58
Antai Fine Chemical Technology Co.,Limited	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
SIMAGCHEM CORP	58
Shanghai UCHEM Inc.	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58

View Lastest Price from 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-01	2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 128694-63-3	$1.00	1KG	99%	200kg	Career Henan Chemical Co

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
128694-63-3
$1.00
99%
Career Henan Chemical Co

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID Spectrum

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID(128694-63-3)¹HNMR 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID(128694-63-3)¹HNMR 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID(128694-63-3)¹⁹FNMR

128694-63-3(2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID)Related Search:

5-Hydroxy-1-methylpyrazole 1-Methylpyrazole 4-BROMO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-amine ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID (1-Methyl-3-(trifluoroMethyl)-1H-pyrazol-4-yl)Methanol Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 2-(3-CYANO-4-FLUORO-PHENYL)-5-TRIFLUORO-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID

2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 4-CHLORO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID 2-ETHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 4-BROMO-2-METHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID 2-ETHYL-5-TRIFLUOROMETHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

AKOS B030773 AKOS B030771 AKOS B030772

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1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE) 2-methyl-5-(trifluoromethyl)-3-pyrazolecarboxylic acid 2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid EU-0083300 MLS000850704 Pyrazole-5-carboxylic acid, 3-trifluorromethyl-1-methyl- SMR000456721 TimTec1_003188 ZERO/005391 1-Methyl-3-(trifluoromethy)-2H-pyrazole-5-caboxylic Acid 1H-Pyrazole-5-carboxylic acid, 1-methyl-3-(trifluoromethyl)- 1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-carboxylic acid 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 128694-63-3