6-chloro-5-iodonicotinic acid
- CAS No.
- 59782-87-5
- Chemical Name:
- 6-chloro-5-iodonicotinic acid
- Synonyms
- 5-Iod-6-chlornicotinsaeure;6-chloro-5-iodonicotinic acid;6-chloro-5-iodopyridine-3-carboxylicaci;6-Chloro-5-iodo-3-pyridinecarboxylic acid;6-chloro-5-iodopyridine-3-carboxylic acid;6-Chloro-5-iodo-pyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-5-iodo-
- CBNumber:
- CB71541457
- Molecular Formula:
- C6H3ClINO2
- Molecular Weight:
- 283.45
- MDL Number:
- MFCD11100073
- MOL File:
- 59782-87-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
6-chloro-5-iodonicotinic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR303730 | 6-Chloro-5-iodonicotinic acid 98% | 59782-87-5 | 25g | $256 | 2026-06-04 | Buy |
| Apolloscientific | OR303730 | 6-Chloro-5-iodonicotinic acid 98% | 59782-87-5 | 100g | $970 | 2026-06-04 | Buy |
| Synthonix | C41944 | 6-Chloro-5-iodonicotinic acid 95% | 59782-87-5 | 100mg | $52 | 2026-05-06 | Buy |
| Synthonix | C41944 | 6-Chloro-5-iodonicotinic acid 95% | 59782-87-5 | 250mg | $58 | 2026-05-06 | Buy |
| Synthonix | C41944 | 6-Chloro-5-iodonicotinic acid 95% | 59782-87-5 | 1g | $59 | 2026-05-06 | Buy |
6-chloro-5-iodonicotinic acid Chemical Properties, Uses, Production
Synthesis
59782-91-1
59782-87-5
General procedure for the synthesis of 5-iodo-6-chloronicotinic acid from 2-chloro-3-iodo-5-methylpyridine: 2-chloro-3-iodo-5-methylpyridine (4.00 g, 15.8 mmol) was dissolved in water (160 mL), and heated at 80 °C until completely dissolved. Potassium permanganate (6.24 g, 39.5 mmol) was added in batches and the reaction mixture was heated to reflux at 100 °C for 3 hours. Upon completion of the reaction, the hot reaction solution was filtered through Celite 545 and the filter cake was washed with hot water (3 x 20 mL). The filtrates were combined, concentrated to half the original volume and subsequently cooled to 0 °C. The pH was adjusted to 1-2 by slow dropwise addition of concentrated aqueous hydrochloric acid (37%, w/w). the precipitate precipitated was collected by filtration, washed with cold water (2 × 5 mL) and dried in a vacuum desiccator to afford 6-chloro-5-iodonicotinic acid (795 mg, 2.8 mmol) as a white solid in 18% yield. The product characterization data were as follows: thin-layer chromatography Rf value (ethyl acetate/cyclohexane, 5/5, v/v) 0.40; melting point 208-210 °C (literature value: 198-200 °C); infrared spectroscopy (KBr) ν 851, 1283, 1365, 1701, 2400-3100 cm-1; 1H NMR (200 MHz, DMSO-d6) δ 8.65 (d, 1H, J = 2.0 Hz, H-4), 8.83 (d, 1H, J = 2.0 Hz, H-2); 13C NMR (50 MHz, DMSO-d6) δ 96.0 (C-5), 126.9 (C-3), 149.4 (C-4 or C-2), 149.6 (C-4 or C-2), 157.1 (C-6) 164.3 (C=O); ESI-MS m/z 281.87 [M-H]-.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
6-chloro-5-iodonicotinic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Nanjing Duolong Bio-tech Co.,Ltd. | 18905173768 | 52513593@qq.com | China | 2337 | 50 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 |
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