FMOC-b-Ala-OH
- CAS No.
- 35737-10-1
- Chemical Name:
- FMOC-b-Ala-OH
- Synonyms
- FMoc-β-Ala-OH;FMOC-BETA-ALA-OH;fmoc-β-ala;3-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)propanoic acid;FMoc-Beta-Ala;FMoc-B-Ala;Fmoc-β-alanine;FMOC-BETA-ALANINE;-Ala-OH;N-Fmoc-β-alanine
- CBNumber:
- CB9395385
- Molecular Formula:
- C18H17NO4
- Molecular Weight:
- 311.33
- MDL Number:
- MFCD00063328
- MOL File:
- 35737-10-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 142-147 °C |
|---|---|
| Boiling point | 451.38°C (rough estimate) |
| Density | 1.2626 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in water or 1% acetic acid |
| form | powder to crystal |
| pka | 4.41±0.10(Predicted) |
| color | White to Almost white |
| Water Solubility | Soluble in water and 1% acetic acid. |
| BRN | 2302327 |
| Major Application | peptide synthesis |
| InChI | 1S/C18H17NO4/c20-17(21)9-10-19-18(22)23-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,19,22)(H,20,21) |
| InChIKey | LINBWYYLPWJQHE-UHFFFAOYSA-N |
| SMILES | OC(=O)CCNC(=O)OCC1c2ccccc2-c3ccccc13 |
| CAS DataBase Reference | 35737-10-1(CAS DataBase Reference) |
| FDA UNII | 7G6VG65WAL |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2924 29 70 | |||||||||
| HazardClass | IRRITANT | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
FMOC-b-Ala-OH price More Price(90)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52024 | FMOC-ß-ALA-OH Novabiochem? | 35737-10-1 | 5G | $58.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52024 | FMOC-ß-ALA-OH Novabiochem? | 35737-10-1 | 25g | $220 | 2026-04-30 | Buy |
| Sigma-Aldrich | 47587 | Fmoc-β-Ala-OH ≥99.0% (HPLC) | 35737-10-1 | 5G | $82.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 47587 | Fmoc-β-Ala-OH ≥99.0% (HPLC) | 35737-10-1 | 25g | $200 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52024 | FMOC-ß-ALA-OH Novabiochem® | 35737-10-1 | 100 g | $793 | 2025-07-31 | Buy |
FMOC-b-Ala-OH Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powde
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
28920-43-6
107-95-9
35737-10-1
Under stirring conditions, β-alanine (β-Ala, 0.5 g, 6.61 mmol) was dissolved in 10% aqueous Na2CO3 solution (12 ml) in a 50 ml flask. The flask was cooled in an ice bath followed by slow dropwise addition of Fmoc-Cl (1.45 g, 5.61 mmol) in dioxane (10 ml) solution. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, the aqueous phase layer was separated by adding water (80 ml) for dilution and washed three times (75 ml each) with ether. The aqueous phase layer was acidified to pH=2 with 2N HCl aqueous solution and subsequently extracted with ethyl acetate three times (75 ml each). The organic phase layers were combined and concentrated to give 1.50 g of crude product. The crude product was recrystallized by a solvent mixture of ethyl acetate and hexane (1:2, 30 ml, v/v) and filtered under reduced pressure to obtain a white solid, Fmoc-β-Ala. yield: 1.41 g (81%). NMR (CDCl3) δ 2.6 (t, 2H, NHCH2CH2COOH), 3.47 (d, 2H, J = 7.0 Hz, NHCH2CH2COOH), 4.19 (t, 1H, J = 6.0 Hz, Fmoc-CH), 4.39 (d, 2H, J = 7.0 Hz, Fmoc-CH2), 7.29 (t, 2H , J = 7.3 Hz, Ar-H), 7.38 (t, 2H, J = 7.3 Hz, Ar-H), 7.56 (d, 2H, J = 7.0 Hz, Ar-H), 7.74 (d, 2H, J = 7.5 Hz, Ar-H).
References
[1] Tetrahedron, 1991, vol. 47, # 14-15, p. 2389 - 2400
[2] Patent: US2009/131681, 2009, A1. Location in patent: Page/Page column 3
[3] Journal of Organic Chemistry, 1972, vol. 37, # 22, p. 3404 - 3409
[4] Bioorganic Chemistry, 1996, vol. 24, # 1, p. 50 - 58
[5] Russian Journal of General Chemistry, 2010, vol. 80, # 12, p. 2572 - 2589
FMOC-b-Ala-OH Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from FMOC-b-Ala-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Fmoc-β-Ala-OH
35737-10-1
|
1kg | 98% | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-09-11 | FMOC-beta-Ala-OH
35737-10-1
|
1KG | 98%min | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-25 | Fmoc-β-Ala-OH
35737-10-1
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- Fmoc-β-Ala-OH
35737-10-1
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- FMOC-beta-Ala-OH
35737-10-1
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Fmoc-β-Ala-OH
35737-10-1
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
