4-P-PDOT
- CAS No.
- 134865-74-0
- Chemical Name:
- 4-P-PDOT
- Synonyms
- AH-024;4-P-PDOT;4-P-PDOT, 10 mM in DMSO;4-PHENYL-2-PROPIONAMIDOTETRALIN;4-P-PDOT, MT2 selective melatonin receptor antagonist;N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide;N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide;Propanamide, N-(1,2,3,4-tetrahydro-4-phenyl-2-naphthalenyl)-;4-P-PDOT; 4PPDOT; 4P-PDOT; AH-024; 4-PHENYL-2- PROPIONAMIDOTETRALIN.;Melatonin,Melatonin Receptor,GSSG,Nrf2,GSH,4PPDOT,ERK,memory,damage,Inhibitor,oxidative,4 P PDOT,MT2,inhibit
- CBNumber:
- CB7203987
- Molecular Formula:
- C19H21NO
- Molecular Weight:
- 279.38
- MDL Number:
- MFCD00901545
- MOL File:
- 134865-74-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 166 °C |
|---|---|
| Boiling point | 480.1±45.0 °C(Predicted) |
| Density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble in DMSO > 10 mM |
| form | powder |
| pka | 15.87±0.40(Predicted) |
| color | white to beige |
| InChI | 1S/C19H21NO/c1-2-19(21)20-16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,2,12-13H2,1H3,(H,20,21) |
| InChIKey | RCYLUNPFECYGDW-UHFFFAOYSA-N |
| SMILES | N(C1CC(c3c(cccc3)C1)c2ccccc2)C(=O)CC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| RTECS | TX1498350 | |||||||||
| HS Code | 2924.29.7790 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
4-P-PDOT price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1189 | 4-P-PDOT ≥98% (HPLC) | 134865-74-0 | 5MG | $114 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1189 | 4-P-PDOT ≥98% (HPLC) | 134865-74-0 | 25MG | $444 | 2026-04-30 | Buy |
| TCI Chemical | P2587 | 4-P-PDOT | 134865-74-0 | 5MG | $41 | 2026-04-30 | Buy |
| TCI Chemical | P2587 | 4-P-PDOT | 134865-74-0 | 25MG | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 17411 | 4-P-PDOT ≥98% | 134865-74-0 | 5mg | $73 | 2026-04-30 | Buy |
4-P-PDOT Chemical Properties, Uses, Production
Uses
4-P-PDOT is a MT2 melatonin receptor ligand.
Definition
ChEBI: N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide is a member of tetralins.
Biological Activity
Melatonin receptor antagonist, >300-fold selective for the MT 2 (vs MT 1 ) subtype.
Biochem/physiol Actions
4-P-PDOT is a slelctive MT2 melatonin receptor antagonist 300 fold selective for MT2 (MEL-1B-R) vs MT1 (MEL-1A-R) melatonin receptor subtype.
in vivo
4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice[2].
| Animal Model: | Klotho mutant mice treatment with Melatonin[2] |
| Dosage: | 0.5 mg/kg or 1.0 mg/kg |
| Administration: | Intravenous injection |
| Result: | Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice. |
IC 50
MT2
4-P-PDOT Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
View Latest Price from 4-P-PDOT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-30 | 4-P-PDOT
134865-74-0
|
$52.00-186.00 | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-20 | 4-P-PDOT
134865-74-0
|
$52.00-186.00 | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-22 | 4-P-PDOT
134865-74-0
|
$1.00 | 1g | Min98%HPLC/LC | Career Henan Chemica Co |
