2-Fluoroethyl 4-methylbenzenesulfonate
- CAS No.
- 383-50-6
- Chemical Name:
- 2-Fluoroethyl 4-methylbenzenesulfonate
- Synonyms
- 2-FLUOROETHYL TOSYLATE;Fluoroethylp-tosylate;2-Fluoroethanol tosylate;L-TRYPTOPHAN/D-TRYPTOPHAN;2-Fluoroethyl 4-methylben;FLUOROETHYL 4-TOLUENESULFONATE;Fluoroethyl p-toluenesulfonate;2-Fluoro-ethanol 1-( tosylate);2-Fluoroethyl p-Toluenesulfonate;2-fluoroethyl 4-methylbenzenesulfonate
- CBNumber:
- CB7206867
- Molecular Formula:
- C9H11FO3S
- Molecular Weight:
- 218.25
- MDL Number:
- MFCD01658061
- MOL File:
- 383-50-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 140°C/1mmHg(lit.) |
|---|---|
| Density | 1.290 g/cm3 |
| refractive index | 1.5060 to 1.5100 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Clear Colourless to Pale Brown |
| InChI | InChI=1S/C9H11FO3S/c1-8-2-4-9(5-3-8)14(11,12)13-7-6-10/h2-5H,6-7H2,1H3 |
| InChIKey | XNRDLSNSMTUXBV-UHFFFAOYSA-N |
| SMILES | C(OS(C1=CC=C(C)C=C1)(=O)=O)CF |
| CAS DataBase Reference | 383-50-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| HS Code | 2930909899 | |||||||||
| NFPA 704 |
|
2-Fluoroethyl 4-methylbenzenesulfonate price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1056 | 2-Fluoroethyl p-Toluenesulfonate >98.0%(GC) | 383-50-6 | 1g | $102 | 2026-04-30 | Buy |
| TCI Chemical | F1056 | 2-Fluoroethyl p-Toluenesulfonate >98.0%(GC) | 383-50-6 | 5g | $355 | 2026-04-30 | Buy |
| TRC | TRC-F591735-1G | 2-Fluoroethyl Tosylate | 383-50-6 | 1g | $140 | 2026-06-03 | Buy |
| Biosynth | FF29461 | 2-Fluoroethyl tosylate | 383-50-6 | 5g | $349.4 | 2026-06-04 | Buy |
| Biosynth | FF29461 | 2-Fluoroethyl tosylate | 383-50-6 | 10g | $524.1 | 2026-06-04 | Buy |
2-Fluoroethyl 4-methylbenzenesulfonate Chemical Properties, Uses, Production
Uses
2-Fluoroethyl Tosylate is an intermediate used in the preparation and pre-clinical evaluation of new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer by positron emission tomography (PET) imaging.
Synthesis
371-62-0
98-59-9
383-50-6
2-Fluoroethanol (1.00 mL, 16.9 mmol), p-toluenesulfonyl chloride (3.85 g, 20.2 mmol), N-methylmorpholine (9.30 mL, 84.5 mmol), and dichloromethane (50 mL) were added to the reaction vessel, and the reaction was stirred for 17 hours at room temperature. After completion of the reaction, water was added to the reaction system and extracted with ethyl acetate three times to combine the organic layers. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was purified by fast silica gel column chromatography (eluent: ethyl acetate/hexane=19:81→40:60) to afford fluoroethyl p-toluenesulfonate (3.79 g, 17.2 mmol, yield >100%) as a pale yellow liquid.1H NMR (600 MHz, CDCl3): δ 7.81 (d, J=8.4 Hz, 2H), δ 7.36 (d, J=8.4 Hz, 2H), 4.63-4.60 (m, 1H), 4.55-4.52 (m, 1H), 4.31-4.27 (m, 1H), 4.26-4.23 (m, 1H), 2.46 (s, 3H). lRMS (EI) Calculated value (C9H11F3O): 218.0, measured value: 218.0.
References
[1] Patent: US2018/30074, 2018, A1. Location in patent: Paragraph 0188-0191
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 7, p. 286 - 292
[3] Patent: US2013/177501, 2013, A1. Location in patent: Paragraph 0168
[4] Patent: US9168317, 2015, B2. Location in patent: Page/Page column 25; 26
[5] Patent: US9314541, 2016, B2. Location in patent: Page/Page column 26
2-Fluoroethyl 4-methylbenzenesulfonate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiaxing Fubo Biotechnology Co., Ltd. | 156-571-11153 18157018567; | sales@fluorio.com | China | 93 | 58 |
| Beijing FYF Chemicals Co., Ltd | 010-57903446 15869909019 | 168931144@qq.com | China | 2876 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
View Latest Price from 2-Fluoroethyl 4-methylbenzenesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2-Fluoroethyl 4-methylbenzenesulfonate
383-50-6
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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2024-06-26 | 2-Fluoroethyl 4-methylbenzenesulfonate
383-50-6
|
$1.00 | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-02-22 | 2-Fluoroethyl 4-methylbenzenesulfonate
383-50-6
|
1KG | 97.5% | 100 tons | Honest Joy Holdings Limited |
-
- 2-Fluoroethyl 4-methylbenzenesulfonate
383-50-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Fluoroethyl 4-methylbenzenesulfonate
383-50-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Fluoroethyl 4-methylbenzenesulfonate
383-50-6
- $0.00
- 97.5%
- Honest Joy Holdings Limited
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