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2-Chloro-3-fluoro-4-iodopyridine

2-Chloro-3-fluoro-4-iodopyridine structure

CAS No.: 148639-07-0

Chemical Name:: 2-Chloro-3-fluoro-4-iodopyridine

Synonyms: 2-CHLORO-3-FLUORO-4-IODOPYRIDINE;Pyridine, 2-chloro-3-fluoro-4-iodo-;2-Chloro-3-fluoro-4-iodopyridine 95+%;2-CHLORO-3-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH

CBNumber:: CB7225275

Molecular Formula:: C5H2ClFIN

Molecular Weight:: 257.43

MDL Number:: MFCD04972389

MOL File:: 148639-07-0.mol

MSDS File:: SDS

Last updated:2026-05-28 02:56:27

Product description	Number	Pack Size	Price
2-Chloro-3-fluoro-4-iodopyridine	C3375	1G	$150
2-Chloro-3-fluoro-4-iodopyridine >98%	PC445020	1g	$21
2-Chloro-3-fluoro-4-iodopyridine >98%	PC445020	5g	$22
2-Chloro-3-fluoro-4-iodopyridine >98%	PC445020	25g	$88
2-Chloro-3-fluoro-4-iodopyridine >98%	PC445020	100g	$332
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2-Chloro-3-fluoro-4-iodopyridine Properties

Melting point	97 °C
Boiling point	246.1±35.0 °C(Predicted)
Density	2.129±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	-0.22±0.10(Predicted)
form	powder to crystal
color	White to Light yellow to Light orange
InChI	InChI=1S/C5H2ClFIN/c6-5-4(7)3(8)1-2-9-5/h1-2H
InChIKey	GONULLRFSHKLBS-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=CC(I)=C1F
CAS DataBase Reference	148639-07-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

HS Code

2933399990

NFPA 704

	0
2		0

2-Chloro-3-fluoro-4-iodopyridine price More Price(87)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C3375	2-Chloro-3-fluoro-4-iodopyridine	148639-07-0	1G	$150	2026-04-30	Buy
Apolloscientific	PC445020	2-Chloro-3-fluoro-4-iodopyridine >98%	148639-07-0	1g	$21	2026-06-04	Buy
Apolloscientific	PC445020	2-Chloro-3-fluoro-4-iodopyridine >98%	148639-07-0	5g	$22	2026-06-04	Buy
Apolloscientific	PC445020	2-Chloro-3-fluoro-4-iodopyridine >98%	148639-07-0	25g	$88	2026-06-04	Buy
Apolloscientific	PC445020	2-Chloro-3-fluoro-4-iodopyridine >98%	148639-07-0	100g	$332	2026-06-04	Buy

Product number	Packaging	Price	Buy
C3375	1G	$150	Buy
PC445020	1g	$21	Buy
PC445020	5g	$22	Buy
PC445020	25g	$88	Buy
PC445020	100g	$332	Buy

2-Chloro-3-fluoro-4-iodopyridine Chemical Properties,Uses,Production

Uses

2-Chloro-3-fluoro-4-iodopyridine is a polyhalogenated compound with a wide uses. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

17282-04-1

148639-07-0

The general procedure for the synthesis of 2-chloro-3-fluoro-4-iodopyridine using 2-chloro-3-fluoropyridine as a starting material was as follows: a lithium 2-diisopropylammonium solution (2M, dissolved in a mixed solvent of tetrahydrofuran/ethylbenzene/heptane, 155 mL, 0.31 mol) was added slowly and dropwise over a period of 40 min at -70 °C to a 2-chloro-3-fluoropyridine (31 g, 0.235 mol) tetrahydrofuran (200 mL) solution. After the dropwise addition, the reaction mixture was continued to be stirred at -70 °C for 4 hours. Subsequently, a solution of iodine (69 g, 0.2 mol) in tetrahydrofuran (100 mL) was added dropwise over a period of 30 min, and after keeping the reaction at -70 °C for 30 min, the reaction was slowly warmed up to room temperature, and the warming up process was controlled to be completed in 1 hour. The reaction mixture was poured into aqueous sodium bisulfite solution (20% v/v, 2 L) and extracted with ether (3 x 300 mL). The organic phases were combined and washed sequentially with aqueous sodium metabisulfite (20% v/v, 2L) and water (200 mL), dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a colorless oily substance. The oily material was ground with ether to afford the target product 2-chloro-3-fluoro-4-iodopyridine as a reddish brown solid (28 g, 46% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.87 (d, J=5.0 Hz, 1H), 7.66 (ddd, J=5.0,4.0,0.4 Hz, 1H).

References

[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 107-108
[2] Tetrahedron, 1993, vol. 49, # 16, p. 3325 - 3342

2-Chloro-3-fluoro-4-iodopyridine Preparation Products And Raw materials

Raw materials

2-Chloro-3-fluoropyridine Tetrahydrofuran Lithium diisopropylamide Water Sodium metabisulfite

iodine Ethylbenzene Heptane

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Preparation Products

2-Chloro-3-fluoro-4-iodopyridine Suppliers

Global( 183)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Antai Fine Chemical Technology Co.,Limited	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from 2-Chloro-3-fluoro-4-iodopyridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
	2020-01-03	2-CHLORO-3-FLUORO-4-IODOPYRIDINE 148639-07-0	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

2-CHLORO-3-FLUORO-4-IODOPYRIDINE
148639-07-0
$1.10
99.00%
Dideu Industries Group Limited

2-CHLORO-3-FLUORO-4-IODOPYRIDINE
148639-07-0
$9.80
≥99%
Career Henan Chemical Co

2-Chloro-3-fluoro-4-iodopyridine Spectrum

2-Chloro-3-fluoro-4-iodopyridine(148639-07-0)¹HNMR

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2-CHLORO-3-FLUORO-4-IODOPYRIDINE 2-Chloro-3-fluoro-4-iodopyridine 95+% Pyridine, 2-chloro-3-fluoro-4-iodo- 2-CHLORO-3-FLUORO-4-IODOPYRIDINE ISO 9001：2015 REACH 148639-07-0 C5H2NClFI C5H2ClFIN Pyridine Boronic Acid Fluorin-contained pyridine series