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2-Chloro-3-methyl-5-nitropyridine

2-Chloro-3-methyl-5-nitropyridine Structure
2-Chloro-3-methyl-5-nitropyridine structure
CAS No.
22280-56-4
Chemical Name:
2-Chloro-3-methyl-5-nitropyridine
Synonyms
2-CHLORO-5-NITRO-3-PICOLINE;2-C;BUTTPARK 95\50-52;TIMTEC-BB SBB003831;2-Chloro-5-nitro-3-picoline,98%;2-CHLORO-5-NITRO-3-METHYLPYRIDINE;2-CHLORO-3-METHYL-5-NITROPYRIDINE;2-Chloro-5-nitro-3-picoline, 98% 1GR;Pyridine, 2-chloro-3-methyl-5-nitro-;2-Chloro-3-methyl-5-nitropyridine,99%
CBNumber:
CB7319385
Molecular Formula:
C6H5ClN2O2
Molecular Weight:
172.57
MDL Number:
MFCD00173686
MOL File:
22280-56-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
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2-Chloro-3-methyl-5-nitropyridine Properties

Melting point 45-50 °C
Boiling point 145 °C / 18mmHg
Density 1.5610 (rough estimate)
refractive index 1.5500 (estimate)
Flash point >110°C
storage temp. 2-8°C
solubility soluble in Methanol
form Crystalline Powder
pka -3.61±0.10(Predicted)
color Light beige to cream
Sensitive Hygroscopic
InChI InChI=1S/C6H5ClN2O2/c1-4-2-5(9(10)11)3-8-6(4)7/h2-3H,1H3
InChIKey OSIOIGXJUZTWRI-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C([N+]([O-])=O)C=C1C
CAS DataBase Reference 22280-56-4(CAS DataBase Reference)
FDA UNII 45ZN7UCB3M
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H315-H318-H335
Precautionary statements  P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-20/21/22-41-37/38-22
Safety Statements  37/39-26-39
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333999
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

2-Chloro-3-methyl-5-nitropyridine price More Price(77)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 736961 2-Chloro-3-methyl-5-nitropyridine 97% 22280-56-4 1g $41.9 2023-06-20 Buy
Sigma-Aldrich 736961 2-Chloro-3-methyl-5-nitropyridine 97% 22280-56-4 5g $178 2023-01-07 Buy
TCI Chemical C2020 2-Chloro-3-methyl-5-nitropyridine >98.0%(GC) 22280-56-4 1g $31 2026-04-30 Buy
TCI Chemical C2020 2-Chloro-3-methyl-5-nitropyridine >98.0%(GC) 22280-56-4 5g $89 2026-04-30 Buy
Usbiological 270280 2-Chloro-3-methyl-5-nitropyridine Asreported 22280-56-4 10g $333 2026-06-03 Buy
Product number Packaging Price Buy
736961 1g $41.9 Buy
736961 5g $178 Buy
C2020 1g $31 Buy
C2020 5g $89 Buy
270280 10g $333 Buy

2-Chloro-3-methyl-5-nitropyridine Chemical Properties, Uses, Production

Chemical Properties

Light beige to cream colored crystalline powder

Uses

2-Chloro-3-methyl-5-nitropyridine is a nitropyridine compound, mainly used as an organic synthetic raw material or pharmaceutical intermediate.

Synthesis

2-HYDROXY-3-METHYL-5-NITROPYRIDINE

21901-34-8

2-Chloro-3-methyl-5-nitropyridine

22280-56-4

Synthesis of compound 20: Compound 19 (3-methyl-5-nitropyridin-2(1H)-one, 16.60 g, 0.1 mol) was added to 80 mL of phosphoryl chloride (POCl3), heated to reflux and maintained for 8 hours. Upon completion of the reaction, excess phosphorus trichloride was removed by distillation. The reaction mixture was slowly poured into 300 g of crushed ice and a dark brown precipitate precipitated. The precipitate was collected by filtration to give 16.18 g of the target product 2-chloro-3-methyl-5-nitropyridine in 87.1% yield. The melting point of the product was 44.5-45.8 °C (literature value: 47-48 °C) [J.O.C., 1949, 14, 328-332].

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 23, p. 7653 - 7668
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 10
[3] Journal of Organic Chemistry, 1949, vol. 14, p. 328,331
[4] Patent: US2010/29684, 2010, A1. Location in patent: Page/Page column 14
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 985 - 995

2-Chloro-3-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Hydroxy-3-methyl-5-nitropyridine

Preparation Products

2-Chloro-3-methyl-5-bromopyridine

2-Chloro-3-methyl-5-nitropyridine Suppliers

Global Suppliers ( 312)
Supplier Tel Email Country ProdList Advantage
Changzhou Helios Biomedical Science and Technology Co.,LTD. 18961213068 121257724@qq.com China 493 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ChangShu Haitian Fine Chemicals Co.,Ltd 13913622609 974295387@qq.com China 192 61
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Changzhou Helios Biomedical Science and Technology Co.,LTD. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ChangShu Haitian Fine Chemicals Co.,Ltd 61
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 2-Chloro-3-methyl-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-3-methyl-5-nitropyridine pictures 2026-09-02 2-Chloro-3-methyl-5-nitropyridine
22280-56-4
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2-Chloro-3-methyl-5-nitropyridine pictures 2026-06-30 2-Chloro-3-methyl-5-nitropyridine
22280-56-4
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chloro-3-methyl-5-nitropyridine pictures 2026-02-02 2-Chloro-3-methyl-5-nitropyridine
22280-56-4
 $1.00 1g 98% 50tons Shaanxi Dideu Medichem Co. Ltd

2-Chloro-3-methyl-5-nitropyridine Spectrum

2-Chloro-3-methyl-5-nitropyridine(22280-56-4)MS2-Chloro-3-methyl-5-nitropyridine(22280-56-4)1HNMR2-Chloro-3-methyl-5-nitropyridine(22280-56-4)13CNMR2-Chloro-3-methyl-5-nitropyridine(22280-56-4)IR12-Chloro-3-methyl-5-nitropyridine(22280-56-4)IR2

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2-Chloro-3-methyl-5-nitropyridine,99% BUTTPARK 95\50-52 2-CHLORO-5-NITRO-3-METHYLPYRIDINE 2-CHLORO-5-NITRO-3-PICOLINE 2-CHLORO-3-METHYL-5-NITROPYRIDINE 2-Chloro-3-methyl-5-nitropyridine 2-Chloro-5-nitro-3-picoline 2-CHLORO-5-NITRO-3-PICOLINE (2-CHLORO-3-METHYL-5-NITROPYRIDINE) TIMTEC-BB SBB003831 2-Chloro-3-methyl-5-nitropyridine ,98% 2-Chloro-5-nitro-3-picoline,98% 2-Chloro-5-nitro-3-picoline, 98% 1GR 2-C 2-Chloro-3-methyl-5-nitropyridine > Pyridine, 2-chloro-3-methyl-5-nitro- 2-Chloro-3-methyl-5-nitropyridine ISO 9001：2015 REACH 22280-56-4 Chloropyridines Halopyridines Heterocycle-Pyridine series Heterocyclic Building Blocks Building Blocks Chemical Synthesis Halides Pyridines Chloropyridines Halopyridines Boronic Acid Pyridine Pyridines, Pyrimidines, Purines and Pteredines Pyridine series compounds of pyridine C6