2-Isopropyl-2-phenylacetic acid
- CAS No.
- 3508-94-9
- Chemical Name:
- 2-Isopropyl-2-phenylacetic acid
- Synonyms
- Nsc22982;RARECHEM AL BO 0360;2-Phenylisovaleric acid;3-methyl-2-phenyl-butyricaci;à-isopropylphenylacetic acid;α-Isopropylphenylacetic acid;α-Isopropylbenzeneacetic acid;3-methyl-2-phenyl-butyricacid;2-Phenyl-3-methylbutanoic acid;2-ISOPROPYL-2-PHENYLACETIC ACID
- CBNumber:
- CB7239771
- Molecular Formula:
- C11H14O2
- Molecular Weight:
- 178.23
- MDL Number:
- MFCD00021708
- MOL File:
- 3508-94-9.mol
- MSDS File:
- SDS
| Melting point | 59-61°C |
|---|---|
| Boiling point | 270.46°C (rough estimate) |
| Density | 1.0292 (rough estimate) |
| refractive index | 1.5167 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.26±0.10(Predicted) |
| Appearance | White to off-white Solid |
| Water Solubility | Slightly soluble in water. |
| BRN | 2045915 |
| CAS DataBase Reference | 3508-94-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN3261 | |||||||||
| RTECS | ET5750060 | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 2942000090 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Isopropyl-2-phenylacetic acid price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DAA50894 | 3-Methyl-2-phenylbutyric acid | 3508-94-9 | 10g | $354 | 2026-06-04 | Buy |
| Apolloscientific | OR61178 | 3-Methyl-2-phenylbutanoic acid 95% | 3508-94-9 | 1g | $30 | 2026-06-04 | Buy |
| Activate Scientific | AS90252 | 2-Isopropyl-2-phenylacetic acid 95% | 3508-94-9 | 1g | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR61178 | 3-Methyl-2-phenylbutanoic acid 95% | 3508-94-9 | 5g | $67 | 2026-06-04 | Buy |
| Activate Scientific | AS90252 | 2-Isopropyl-2-phenylacetic acid 95% | 3508-94-9 | 5g | $71 | 2026-06-04 | Buy |
2-Isopropyl-2-phenylacetic acid Chemical Properties,Uses,Production
Uses
alpha-Isopropylphenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Synthesis
75-30-9
103-82-2
3508-94-9
GENERAL METHOD: 5 mL of a 0.24 M solution of diorganometallic reagent 1b or 1c (1.2 mmol) was cooled to 0 °C and appropriate arylacetic acid 2 (1.1 mmol) dissolved in 5 mL of anhydrous THF was added. The resulting mixture was stirred vigorously at 0°C for 2 hours. To the cooled dark brown mixture at the same temperature, 1.7 mmol of appropriate electrophilic reagent was added. The reaction mixture was stirred vigorously and allowed to warm slowly to room temperature overnight. Upon completion of the reaction, the reaction was quenched by slow dropwise addition of 15 mL of H2O. The organic solvent was evaporated in vacuum and the residue was extracted with CH2Cl2 (3 × 10 mL). The aqueous phase was acidified with 1N HCl and extracted again with CH2Cl2 (3 × 10 mL). The organic phases were combined, washed sequentially with H2O (1 × 10 mL) and brine (10 mL), dried (Na2SO4), and the solvent evaporated. The crude product was purified and characterized as follows. For the reaction mixture containing crude β-hydroxyacid 2df, 15 mL of 10% HCl (containing about 15 g of crushed ice) was added on quenching and post-treated as described above. After solvent evaporation, the crude product was purified and characterized as follows. Quenching with D2O was performed in the same manner as the above procedure.
References
[1] Organic Syntheses, 2017, vol. 94, p. 1 - 15
[2] Tetrahedron, 2011, vol. 67, # 19, p. 3470 - 3475
[3] Bulletin de la Societe Chimique de France, 1965, p. 1881 - 1888
[4] Journal of the American Chemical Society, 2011, vol. 133, # 31, p. 11936 - 11939
2-Isopropyl-2-phenylacetic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4545 | 58 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
View Lastest Price from 2-Isopropyl-2-phenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-20 | 2-Isopropyl-2-phenylacetic acid
3508-94-9
|
$1.00 | 1KG | 97-99% | 1000KGS | Career Henan Chemical Co |
-
- 2-Isopropyl-2-phenylacetic acid
3508-94-9
- $1.00
- 97-99%
- Career Henan Chemical Co
