Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Chloro-6-phenylpyrazine

2-Chloro-6-phenylpyrazine

2-Chloro-6-phenylpyrazine Structure
2-Chloro-6-phenylpyrazine structure
CAS No.
41270-62-6
Chemical Name:
2-Chloro-6-phenylpyrazine
Synonyms
C90120;2-Chloro-6-phenylpyrazine;Pyrazine, 2-chloro-6-phenyl-
CBNumber:
CB72448265
Molecular Formula:
C10H7ClN2
Molecular Weight:
190.63
MDL Number:
MFCD03861157
MOL File:
41270-62-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:50
Request For Quotation

2-Chloro-6-phenylpyrazine Properties

Melting point 34-35 °C(Solv: hexane (110-54-3))
Boiling point 111-112 °C(Press: 1 Torr)
Density 1.245±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.48±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H335-H319
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

2-Chloro-6-phenylpyrazine price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth RBA27062 2-Chloro-6-phenylpyrazine 41270-62-6 2.5g $324.5 2026-06-05 Buy
Matrix Scientific 306423 2-Chloro-6-phenylpyrazine 41270-62-6 100.00mg $60 2026-05-19 Buy
Matrix Scientific 306423 2-Chloro-6-phenylpyrazine 41270-62-6 250.00mg $78 2026-05-19 Buy
Matrix Scientific 306423 2-Chloro-6-phenylpyrazine 41270-62-6 1.00g $187 2026-05-19 Buy
Synthonix C53518 2-Chloro-6-phenylpyrazine 97% 41270-62-6 100mg $140 2026-05-06 Buy
Product number Packaging Price Buy
RBA27062 2.5g $324.5 Buy
306423 100.00mg $60 Buy
306423 250.00mg $78 Buy
306423 1.00g $187 Buy
C53518 100mg $140 Buy

2-Chloro-6-phenylpyrazine Chemical Properties, Uses, Production

Synthesis

2,6-Dichloropyrazine

4774-14-5

Phenylboronic acid

98-80-6

2-CHLORO-6-PHENYLPYRAZINE

41270-62-6

General procedure for the synthesis of 2-chloro-6-phenylpyrazine: to a solvent mixture of 2,6-dichloropyrazine (2.0 eq.) dissolved in a 3:1 ratio of aqueous DME with 2M sodium carbonate (0.125 M), phenylboronic acid (1.0 eq.) was added, followed by the addition of PdCl2(dppf)-DCM adduct (0.1 eq.). The reaction mixture was placed in a microwave reactor and heated at 120 °C for 15 min. After completion of the reaction, the crude product was diluted with ethyl acetate and washed with saturated aqueous NaHCO3 solution. After the aqueous phase was saturated with sodium chloride, the organic phase was dried with magnesium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography with the eluent being heptane to a heptane solution containing 30% ethyl acetate, resulting in 2-chloro-6-phenylpyrazine in 75% yield.LC/MS analysis showed a m/z of 191.0 (MH+) and a retention time (Rt) of 1.00 min.

References

[1] Patent: WO2012/4217, 2012, A1. Location in patent: Page/Page column 63
[2] Patent: US2012/225061, 2012, A1. Location in patent: Page/Page column 24
[3] Organic Letters, 2016, vol. 18, # 13, p. 3082 - 3085
[4] Patent: WO2009/89042, 2009, A1. Location in patent: Page/Page column 108

2-Chloro-6-phenylpyrazine synthesis

4774-14-5
98-80-6
41270-62-6
Synthesis of 2-Chloro-6-phenylpyrazine from 2,6-Dichloropyrazine and Phenylboronic acid

2-Chloro-6-phenylpyrazine Preparation Products And Raw materials

Raw materials

2,6-Dichloropyrazine Phenylboronic acid Sodium carbonate 1,2-Dimethoxyethane Water

Preparation Products

2-Chloro-6-phenylpyrazine Suppliers

Global Suppliers ( 44)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
AN PharmaTech Co Ltd 86(21)68097365 sales@anpharma.net China 4875 55
Changzhou Hopschain Chemical Co.,Ltd. 85528066 13775048983 sales@hopschem.com China 31548 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Shanghai Sealing Biotechnology Co. Ltd.. 15721176654;15710104046 1815535157@qq.com China 984 58
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Tetranov Biopharm 64
Shanghai HuanChuan Industry Co.,Ltd. 50
AN PharmaTech Co Ltd 55
Changzhou Hopschain Chemical Co.,Ltd. 55
Amadis Chemical Company Limited 58
Capot Chemical Co.,Ltd. 60
Aikon International Limited 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Shanghai Sealing Biotechnology Co. Ltd.. 58

41270-62-6 (2-Chloro-6-phenylpyrazine) Related Search:

4-(Pyrazin-2-yl)benzoic acid 2-Chloro-3,5,6-triphenylpyrazine 2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine 3-(6-Chloro-pyrazin-2-yl)-benzoic acid 2-Chloro-6-phenylpyrazine
2-Chloro-6-(1-naphthalenyl) pyrazine 2-Chloro-6-(2-naphthalenyl) pyrazine 2-Chloro-6-[4-(1,1-dimethylethyl)phenyl] pyrazine 2,5-Dichloro-3,6-diphenyl pyrazine Methyl 4-(6-chloro-pyrazin-2-yl)-benzoate
2-Chloro-6-(4-methoxy-phenyl)-pyrazine 2-Chloro-6-(4-methylphenyl)pyrazine N-[3-(6-Chloro-pyrazin-2-yl)-phenyl]-acetamide 2-Amino-3-chloro-5-phenylpyrazine 5-Chloro-2,3-diphenylpyrazine 1-oxide
3-Chloro-2,5-diphenylpyrazine 2-Chloro-5-hydrazino-3,6-diphenylpyrazine 5-chloro-2,3-diphenylpyrazine

1of4

C90120 Pyrazine, 2-chloro-6-phenyl- 2-Chloro-6-phenylpyrazine 41270-62-6