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5-(Phenylmethoxy)-1H-indole-3-carbaldehyde

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde structure

CAS No.: 6953-22-6

Chemical Name:: 5-(Phenylmethoxy)-1H-indole-3-carbaldehyde

Synonyms: NSC 71049;5-BENZYLOXY-3-FORMYLINDOLE;5-Benzyloxy-3-formaldehyde;5-BENZYLOXYINDOLE-3-ALDEHYDE;5-Benzyloxy-3-formyl-1H-indole;5-BENZYLOXYINDOLE-3-FORMALDEHYDE;5-BENZYLOXYINDOLE-3-CARBALDEHYDE;5-BENZYLOXY-3-INDOLECARBOXALDEHYDE;5-BENZYLOXYINDOLE-3-CARBOXALDEHYDE;5-BENZYLOXY INDOLE-3-CARBOXYALDEHYDE

CBNumber:: CB7253427

Molecular Formula:: C16H13NO2

Molecular Weight:: 251.28

MDL Number:: MFCD00014562

MOL File:: 6953-22-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:53:25

Product description	Number	Pack Size	Price
5-BENZYLOXY-1H-INDOLE-3-CARBALDEHYDE 95%	53584	5G	$35
5-Benzyloxyindole-3-carboxaldehyde	FB18516	50g	$181
5-Benzyloxyindole-3-carboxaldehyde	FB18516	100g	$290
5-Benzyloxyindole-3-carboxaldehyde	FB18516	250g	$457.5
5-Benzyloxyindole-3-carboxaldehyde	FB18516	500g	$725
More product size

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5-(Phenylmethoxy)-1H-indole-3-carbaldehyde Properties

Melting point	237-238°C
Boiling point	474.2±30.0 °C(Predicted)
Density	1.267±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Ethanol
pka	15.13±0.30(Predicted)
form	powder
color	yellow to brown
Sensitive	Air Sensitive
BRN	208873
InChI	1S/C16H13NO2/c18-10-13-9-17-16-7-6-14(8-15(13)16)19-11-12-4-2-1-3-5-12/h1-10,17H,11H2
InChIKey	DJGNUBADRQIDNQ-UHFFFAOYSA-N
SMILES	O=Cc1c[nH]c2ccc(OCc3ccccc3)cc12
CAS DataBase Reference	6953-22-6(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317-H319

Precautionary statements

P280-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Risk Statements

36-43

Safety Statements

22-24/25-36/37-26

WGK Germany

HazardClass

IRRITANT, AIR SENSITIVE

HS Code

29339990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Sens. 1

NFPA 704

	1
2		0

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde price More Price(85)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	53584	5-BENZYLOXY-1H-INDOLE-3-CARBALDEHYDE 95%	6953-22-6	5G	$35	2026-04-30	Buy
Biosynth	FB18516	5-Benzyloxyindole-3-carboxaldehyde	6953-22-6	50g	$181	2026-06-04	Buy
Biosynth	FB18516	5-Benzyloxyindole-3-carboxaldehyde	6953-22-6	100g	$290	2026-06-04	Buy
Biosynth	FB18516	5-Benzyloxyindole-3-carboxaldehyde	6953-22-6	250g	$457.5	2026-06-04	Buy
Biosynth	FB18516	5-Benzyloxyindole-3-carboxaldehyde	6953-22-6	500g	$725	2026-06-04	Buy

Product number	Packaging	Price	Buy
53584	5G	$35	Buy
FB18516	50g	$181	Buy
FB18516	100g	$290	Buy
FB18516	250g	$457.5	Buy
FB18516	500g	$725	Buy

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

Reactant for preparation of:

Rhodanine merocyanine dyes
Potential topoisomerase II inhibitors
Azithromycin derivatives
Inhibitors of PI3 kinase-α and the mammalian target of rapamycin
Cytotoxic agents
Vascular endothelial growth factor (VEGF) inhibitor
Derivatives of vancomycin and eremomycin
Benzimidazoles as potential antibacterial agents
Light-dependent tumor necrosis factor-α antagonists
Serotonin 5-HT4 Receptor agonists

Uses

An antibacterial agent

Synthesis

1215-59-4

68-12-2

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde

6953-22-6

a) Synthesis of 5-(benzyloxy)-1H-indole-3-carbaldehyde: Phosphoryl chloride (1.5 g, 9.9 mmol) was slowly added dropwise to 15 mL of N,N-dimethylformamide (DMF) cooled in an ice bath under stirring conditions. After removing the ice bath, the reaction was continued with stirring for 15 min. Subsequently, 5-benzyloxyindole (2.00 g, 8.96 mmol) was added and the reaction mixture was heated to 50-60 °C and maintained at this temperature for 1.5 hours. After completion of the reaction, the mixture was poured into ice water and adjusted to alkaline with 2 M sodium hydroxide solution. The mixture was refluxed for 2 minutes, cooled and filtered to collect the solid product. The solid was washed with water and dried to give the target compound 5-(benzyloxy)-1H-indole-3-carboxaldehyde in a yield of 1.88 g (84% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6) with the following chemical shifts: δ 5.88 (s, 1H), 8.20 (s, 1H), 7.68 (d, 1H), 7.50-7.25 (m, 6H), 6.96 (dd, 1H), 5.11 (s, 2H), 4.02 (s, 1H).

References

[1] Patent: WO2005/66132, 2005, A1. Location in patent: Page/Page column 90-91
[2] Patent: US2007/299061, 2007, A1. Location in patent: Page/Page column 17
[3] Synthesis (Germany), 2017, vol. 49, # 18, p. 4141 - 4150
[4] Journal of the Chemical Society, 1958, p. 3493,3494
[5] Journal of the Chemical Society, 1958, p. 3887,3892

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde Preparation Products And Raw materials

Raw materials

5-Benzyloxyindole N,N-Dimethylformamide Sodium hydroxide

Preparation Products

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde Suppliers

Global( 206)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8799	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28675	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5990	58

Supplier	Advantage
Zhejiang ZETian Fine Chemicals Co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
career henan chemical co	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shanghai UCHEM Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
Wuhan Fortuna Chemical Co., Ltd	58

View Lastest Price from 5-(Phenylmethoxy)-1H-indole-3-carbaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-25	5-(Phenylmethoxy)-1H-indole-3-carbaldehyde 6953-22-6		100G	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2020-06-02	5-(Phenylmethoxy)-1H-indole-3-carbaldehyde in stock Factory 6953-22-6	$1.00	1KG	TOP 3 Factory in China		Chemwill Asia Co.,Ltd.
2020-01-09	5-(Phenylmethoxy)-1H-indole-3-carbaldehyde 6953-22-6		500g	98%; 99%	500g；1kg； 10kg; 25kg	Career Henan Chemical Co

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde
6953-22-6
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde in stock Factory
6953-22-6
$1.00
TOP 3 Factory in China
Chemwill Asia Co.,Ltd.

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde
6953-22-6
$0.01
98%; 99%
Career Henan Chemical Co

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde Spectrum

5-(Phenylmethoxy)-1H-indole-3-carbaldehyde(6953-22-6)¹HNMR

6953-22-6(5-(Phenylmethoxy)-1H-indole-3-carbaldehyde)Related Search:

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5-(phenylmethoxy)-1h-indole-3-carbaldehyde 5-BENZYLOXYINDOLE-3-ALDEHYDE 5-BENZYLOXYINDOLE-3-CARBALDEHYDE 5-BENZYLOXYINDOLE-3-CARBOXALDEHYDE 5-BENZYLOXY INDOLE-3-CARBOXYALDEHYDE 5-BENZYLOXYINDOLE-3-FORMALDEHYDE 5-(BENZYLOXY)-3-INDOLECARBOXYALDEHYDE 5-BENZYLOXY-3-FORMYLINDOLE 5-(BENZYLOXY)-1H-INDOLE-3-CARBALDEHYDE 5-BENZYLOXY-3-INDOLECARBOXALDEHYDE 5-(Phenylmethoxy)-1H-indole-3-carbaldehyde in stock Factory 5-Benzyloxy-3-formaldehyde 5-(Benzyloxy)-1H-indole-3-carboxaldehyde 5-Benzyloxy-3-formyl-1H-indole 5-(Phenylmethoxy)-1H-indole-3-carboxaldehyde NSC 71049 5-Benzyloxyindole-3-carboxaldehyde ,98% 5-(Benzyloxy)-3-formyl-1H-indole, 5-(Phenylmethoxy)-1H-indole-3-carboxaldehyde 1H-Indole-3-carboxaldehyde,5-(phenylMethoxy)- 5-Benzyloxyindole-3-carboxaldehyde powder 5-(Phenylmethoxy)-1H-indole-3-carbaldehyde ISO 9001：2015 REACH 6953-22-6 69533-22-6 ALDEHYDE Heterocyclic Building Blocks Indoles Building Blocks Intermediates & Fine Chemicals Pharmaceuticals Building Blocks Heterocyclic Building Blocks blocks Carboxes IndolesOxindoles Indoles and derivatives Indoline & Oxindole Indoles