Cibenzoline succinate
- CAS No.
- 100678-32-8
- Chemical Name:
- Cibenzoline succinate
- Synonyms
- ritmalan;ole(1:1);cipralan;Cinobezile;ro22-7796/001;Cibenzoline succinate;cibenzolinesuccinate(1:1);(+-)-2-(2,2-diphenylcyclopropyl)-2-imidazolinesuccinate(1:1);4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolsuccinate;4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolesuccinate
- CBNumber:
- CB7255168
- Molecular Formula:
- C18H18N2.C4H6O4
- Molecular Weight:
- 380.44
- MDL Number:
- MFCD00941423
- MOL File:
- 100678-32-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Cibenzoline succinate ≥97% (NMR), solid | C1618 | 10mg | $212 |
| Cibenzoline succinate ≥97% (NMR), solid | C1618 | 50mg | $634 |
| Cibenzolinesuccinate 98% | AA0002JB | 100mg | $675 |
| Cibenzolinesuccinate 98% | AA0002JB | 1g | $2550 |
| Cibenzoline succinate | C535725 | 5mg | $115 |
| Melting point | 165° |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: ≥5mg/mL |
| form | solid |
| color | white to off-white |
| Water Solubility | H2O: ≥5mg/mL |
| Stability | Light Sensitive |
| InChI | 1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8) |
| InChIKey | XFUIOIWYMHEPIE-UHFFFAOYSA-N |
| SMILES | OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4 |
| FDA UNII | 38G16RWJ37 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | EJ9960100 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Cibenzoline succinate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C1618 | Cibenzoline succinate ≥97% (NMR), solid | 100678-32-8 | 10mg | $212 | 2026-04-30 | Buy |
| Sigma-Aldrich | C1618 | Cibenzoline succinate ≥97% (NMR), solid | 100678-32-8 | 50mg | $634 | 2026-04-30 | Buy |
| aablocks | AA0002JB | Cibenzolinesuccinate 98% | 100678-32-8 | 100mg | $675 | 2026-05-25 | Buy |
| aablocks | AA0002JB | Cibenzolinesuccinate 98% | 100678-32-8 | 1g | $2550 | 2026-05-25 | Buy |
| TRC | C535725 | Cibenzoline succinate | 100678-32-8 | 5mg | $115 | 2021-12-16 | Buy |
Cibenzoline succinate Chemical Properties,Uses,Production
Uses
Cardiac depressant (anti-arrhythmic).
Uses
Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent.
Definition
ChEBI: Cibenzoline succinate is a diarylmethane.
General Description
Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S() forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.
Biochem/physiol Actions
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
Cibenzoline succinate Preparation Products And Raw materials
Raw materials
Preparation Products
Cibenzoline succinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15082 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 45000 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29119 | 58 |
| Supplier | Advantage |
|---|---|
| CONIER CHEM AND PHARMA LIMITED | 58 |
| Career Henan Chemica Co | 58 |
| Alfa Chemistry | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 58 |
| Sigma-Aldrich | 80 |
| Aikon International Limited | 58 |
| Energy Chemical | 58 |
| Merck KGaA | 58 |
| Santa Cruz Biotechnology Inc | 58 |
| TargetMol | 58 |
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