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ChemicalBook >> CAS DataBase List >>(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Structure
(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone structure
CAS No.
147254-64-6
Chemical Name:
(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone
Synonyms
Ranirestat;AS-3201;AS 3201;SX-3201;Raniestat;AS-3201; SX-3201;Ranirestat,AS-3201;Ranirestat >=97% (HPLC);(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone;(R)-2'-(4-bromo-2-fluorobenzyl)-1'H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone
CBNumber:
CB72589748
Molecular Formula:
C17H11BrFN3O4
Molecular Weight:
420.19
MDL Number:
MFCD00920915
MOL File:
147254-64-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-04 11:17:55
Product description Number Pack Size Price
Ranirestat ≥97% (HPLC) SML1315 5 mg $218
Ranirestat 96.10% CS-4282 5mg $152
Ranirestat 96.10% CS-4282 10mg $249
Ranirestat 96.10% CS-4282 25mg $498
Ranirestat 96.10% CS-4282 50mg $802
More product size
Request For Quotation

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Properties

Melting point 192-193℃
Boiling point 702.7±60.0 °C(Predicted)
Density 1.83
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: 20mg/mL, clear
pka 10.48±0.20(Predicted)
form Solid
color Off-white to pink
optical activity [α]/D -5 to -10°, c =1.0 in methanol
InChI 1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
InChIKey QCVNMNYRNIMDKV-QGZVFWFLSA-N
SMILES O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O
FDA UNII Z26P56GFTV
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1315 Ranirestat ≥97% (HPLC) 147254-64-6 5 mg $218 2026-04-30 Buy
ChemScene CS-4282 Ranirestat 96.10% 147254-64-6 5mg $152 2026-06-04 Buy
ChemScene CS-4282 Ranirestat 96.10% 147254-64-6 10mg $249 2026-06-04 Buy
ChemScene CS-4282 Ranirestat 96.10% 147254-64-6 25mg $498 2026-06-04 Buy
ChemScene CS-4282 Ranirestat 96.10% 147254-64-6 50mg $802 2026-06-04 Buy
Product number Packaging Price Buy
SML1315 5 mg $218 Buy
CS-4282 5mg $152 Buy
CS-4282 10mg $249 Buy
CS-4282 25mg $498 Buy
CS-4282 50mg $802 Buy

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Chemical Properties,Uses,Production

Uses

Ranirestat is an aldose reductase inhibitor used for the treatment of diabetic sensorimotor polyneuropathy.

Biological Activity

Ranirest at (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirest at has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirest at prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.

in vivo

Ranirestat (0.03-1.0 mg/kg; oral administration; once daily; for 3 weeks; male STD-Wistar rats) treatment dose-dependently decreases the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose level. Ranirestat also improves the STZ-induced decrease in motor nerve conduction velocity (MNCV) in a dose-dependent manner[1].

Animal Model:Male STD-Wistar rats aged about (12-week-old; 260-290 g) injected with Streptozotocin (STZ)[1]
Dosage:0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg
Administration:Oral administration; once daily; for 3 weeks
Result:Dose-dependently decreased the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose level.

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone synthesis

1211939-75-1
147254-64-6
Synthesis of (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone from 1211939-75-1

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Preparation Products And Raw materials

Raw materials

1211939-75-1 159213-26-0 4-BROMO-2-FLUOROBENZYLAMINE

Preparation Products

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27602 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ranirestat pictures 2026-08-03 Ranirestat
147254-64-6
 98.83% 10g TargetMol Chemicals Inc.
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  • Ranirestat
    147254-64-6
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(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Spectrum

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone(147254-64-6)1HNMR

147254-64-6((3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone)Related Search:

(3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone Spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone, 2'-[(4-bromo-2-fluorophenyl)methyl]-, (3S)- quercetin 3-O-gentobioside Emodin-8-glucoside Methanone, [8-[(3-fluorophenyl)sulfonyl]-3,8-diazabicyclo[3.2.1]oct-3-yl]-1H-1,2,3-triazol-5-yl-
GANODERIC ACID C2

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AS-3201; SX-3201 SX-3201 (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone AS 3201 Spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone,2'-[(4-broMo-2-fluorophenyl)Methyl]-, (3R)- Ranirestat,AS-3201 Raniestat Ranirestat >=97% (HPLC) (R)-2'-(4-bromo-2-fluorobenzyl)-1'H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone AS-3201 Ranirestat 147254-64-6 C17H11BrFN3O4