Product Details
| Product Name:
Ranirestat |
CAS No.:
147254-64-6 |
| Purity:
98.83% |
Supply Ability:
10g |
| Release date:
2025/12/22 |
Product Introduction
Bioactivity
| Name | Ranirestat |
| Description | Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.Ranirestat inhibits the inflammatory response of high glucose-exposed endothelial cells and may be useful for the study of diabetic sensory-motor polyneuropathy. |
| In vitro | Ranirestat concentration-dependently inhibits sorbitol accumulation in rat erythrocytes and sciatic nerves incubated in a high concentration (500 mg/dl) of glucose[1]. |
| In vivo | In approximately 12-week-old male STD-Wistar rats (260-290 g) injected with Streptozotocin (STZ), Ranirestat (0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg; oral administration, once daily, for 3 weeks) dose-dependently decreased the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose levels[1]. |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.76 mM), Sonication is recommended.
DMSO : 30 mg/mL (71.4 mM), Sonication is recommended.
|
| Keywords | Recombinant humanaldose reductase | Rat lens aldose reductase | Ranirestat | aldose reductase |
| Inhibitors Related | FH1 | Furaneol | Epalrestat | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | Dicoumarol | Lapisteride | Lidorestat | Alpha-Estradiol | Finasteride | AKR1C1-IN-1 | Kopexil | Dutasteride |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Anti-Diabetic Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:1193389-39-7
$31.00 / 10mg
-
CAS:936091-15-5
$195.00 / 1mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States