Ethyl 4-methyl-5-thiazoleactate
- CAS No.
- 20582-55-2
- Chemical Name:
- Ethyl 4-methyl-5-thiazoleactate
- Synonyms
- ETHYL 4-METHYLTHIAZOLE-5-CARBOXYLATE;ETHYL 4-METHYL-5-THIAZOLEACTATE;Ethyl-4-methyl-5-thiazoly formate;ETHYL 4-METHYL-5-THIAZOLYL FORMATE;Ethyl4-Methylthiazole-5-Carboxylat;Ethyl 4-metylthiazole-5-carboxylate;Ethyl-4-methyl-5-thizaolecarboxylate;ETHYL 4-METHYL-5-THIAZOLECARBOXYLATE;4-methyl-5-(ethoxycarbonyl)-thiazole;5-(Ethoxycarbonyl)-4-methyl-1,3-thiazole
- CBNumber:
- CB7260661
- Molecular Formula:
- C7H9NO2S
- Molecular Weight:
- 171.22
- MDL Number:
- MFCD00626873
- MOL File:
- 20582-55-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 28°C(lit.) |
|---|---|
| Boiling point | 233°C(lit.) |
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to lump |
| pka | 1.57±0.10(Predicted) |
| color | White to Almost white |
| LogP | 1.410 (est) |
| CAS DataBase Reference | 20582-55-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HazardClass | IRRITANT |
| HS Code | 2934208090 |
Ethyl 4-methyl-5-thiazoleactate price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1182 | Ethyl 4-Methylthiazole-5-carboxylate >97.0%(GC) | 20582-55-2 | 1g | $54 | 2026-04-30 | Buy |
| TCI Chemical | E1182 | Ethyl 4-Methylthiazole-5-carboxylate >97.0%(GC) | 20582-55-2 | 5g | $161 | 2026-04-30 | Buy |
| Usbiological | 233381 | 4-Methylthiazole-5-carboxylic acid ethyl ester 99+% (GC) ≥99%(GC) | 20582-55-2 | 1g | $255 | 2026-06-03 | Buy |
| Usbiological | 233381 | 4-Methylthiazole-5-carboxylic acid ethyl ester 99+% (GC) ≥99%(GC) | 20582-55-2 | 5g | $509 | 2026-06-03 | Buy |
| Usbiological | 233381 | 4-Methylthiazole-5-carboxylic acid ethyl ester 99+% (GC) ≥99%(GC) | 20582-55-2 | 25g | $1805 | 2026-06-03 | Buy |
Ethyl 4-methyl-5-thiazoleactate Chemical Properties, Uses, Production
Uses
Ethyl 4-methylthiazolium-5-carboxylate is a key intermediate in the synthesis of cefditorenpivoxil. Cefditorenpivoxil was developed by Meiji Seika Co., Ltd. of Japan and launched in Japan in 1994 under the trade name Meiact. Cefditorenpivoxil has a broad antibacterial spectrum against both Gram-positive and Gram-negative bacteria.
Chemical Properties
white to light yellow crystal powde
Synthesis
7210-76-6
20582-55-2
General procedure for the synthesis of ethyl 4-methylthiazole-5-carboxylate from ethyl 2-amino-4-methylthiazole-5-carboxylate: compound 3a (4.0 g, 21.5 mmol) was dissolved in 106 mL of 30% hypophosphite (H3PO2) solution. The reaction system was cooled to -5°C, after which sodium nitrite (NaNO2, 3.0 g, 2.0 eq.) was dissolved in 12 mL of water and slowly added dropwise to the reaction solution. After the dropwise addition, the reaction mixture was transferred to 0°C and kept for 1 hour, then stirring was continued for 2 hours at room temperature. Subsequently, pre-cooled sodium hydroxide solution (17 g NaOH dissolved in 200 mL of water) was added slowly dropwise. The reaction mixture was adjusted to neutral with sodium bicarbonate (NaHCO3) solution and then extracted with ether (Et2O, 50 mL x 3). The organic phases were combined and purified by column chromatography (eluent ratio: petroleum ether:ethyl acetate = 50:1, v/v) to give the yellow semi-solid product 3b (2.1 g, 56% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6231 - 6235
[2] Patent: CN101921268, 2016, B. Location in patent: Paragraph 0128; 0131; 0136-0139
[3] Tetrahedron, 2013, vol. 69, # 22, p. 4436 - 4444
Ethyl 4-methyl-5-thiazoleactate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from Ethyl 4-methyl-5-thiazoleactate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Ethyl 4-methyl-5-thiazoleactate
20582-55-2
|
$2.20-8.80 | 1kg | 99%min | 1000kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-04-04 | Ethyl 4-methyl-5-thiazoleactate
20582-55-2
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-07-22 | Ethyl 4-methyl-5-thiazoleactate
20582-55-2
|
1kg | 99% | 10ton | JINING XINHE CHEMICAL CO., LTD |
-
- Ethyl 4-methyl-5-thiazoleactate
20582-55-2
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Ethyl 4-methyl-5-thiazoleactate
20582-55-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Ethyl 4-methyl-5-thiazoleactate
20582-55-2
- 99%
- JINING XINHE CHEMICAL CO., LTD
