KRX-0501
- CAS No.
- 393856-87-6
- Chemical Name:
- KRX-0501
- Synonyms
- KP 544;KRX-0501;XBVOXAWRUIZEMG-WKILWMFISA-N;Cyclohexanol, 4-[[2-aMino-5-[(4-chlorophenyl)ethynyl]-4-pyriMidinyl]aMino]-, trans- (9CI)
- CBNumber:
- CB72628010
- Molecular Formula:
- C18H19ClN4O
- Molecular Weight:
- 342.82
- MDL Number:
- MFCD20526511
- MOL File:
- 393856-87-6.mol
- MSDS File:
- SDS
| Boiling point | 618.501±65.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.364±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| pka | 15.013±0.40(predicted) |
| FDA UNII | 44CE82289R |
KRX-0501 Chemical Properties, Uses, Production
Uses
KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective[1].
References
[1] Fyfe J A, et al. KP544 amplifies the effects of nerve growth factor on cell differentiation and is neuroprotective[J]. Drug development research, 2004, 62(1): 49-59.
KRX-0501 Preparation Products And Raw materials
Raw materials
Preparation Products
KRX-0501 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
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