PentaMidine-d4 2HCl
- CAS No.
- 50357-45-4
- Chemical Name:
- PentaMidine-d4 2HCl
- Synonyms
- PentaMidine-d4 2HCl;MP601205 dihydrochloride;PentaMidine (dihydrochloride);MP601205 DIHYDROCHLORIDE;PENTAMIDINE;Pentamidine dihydrochloride, 10 mM in DMSO;4,4'-[1,5-Pentanediylbis(oxy)]bisbenzenecarboximidamide] dihydrochloride;Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-, dihydrochloride (9CI);PTP1B,Pneumocystis,Parasite,Antibiotic,antitumor,Pentamidine,MP 601205,Inhibitor,Kidney,MP-601205,carinii,Bacterial,cell-cycle,pneumonia,MP601205,Phosphatase,inhibit,DNA,Pentamidine dihydrochloride,biosynthetics,Fungal,arrest
- CBNumber:
- CB72646436
- Molecular Formula:
- C19H26Cl2N4O2
- Molecular Weight:
- 413.34134
- MDL Number:
- MFCD01667907
- MOL File:
- 50357-45-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Pentamidinedihydrochloride | B3416 | 50mg | $73 |
| 4,4'-(PENTAMETHYLENEDIOXY)DI-BENZAMIDINE DIHYDROCHLORIDE 95.00% | CHM0307889 | 5MG | $500.39 |
| Pentamidinedihydrochloride 98+% | CD31001733 | 10mg | $46 |
| Pentamidinedihydrochloride 98+% | CD31001733 | 50mg | $137 |
| Pentamidinedihydrochloride 98+% | CD31001733 | 100mg | $208 |
| Melting point | 232-234° |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| FDA UNII | I0I0257YP1 |
PentaMidine-d4 2HCl price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | B3416 | Pentamidinedihydrochloride | 50357-45-4 | 50mg | $73 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0307889 | 4,4'-(PENTAMETHYLENEDIOXY)DI-BENZAMIDINE DIHYDROCHLORIDE 95.00% | 50357-45-4 | 5MG | $500.39 | 2021-12-16 | Buy |
| Crysdot | CD31001733 | Pentamidinedihydrochloride 98+% | 50357-45-4 | 10mg | $46 | 2021-12-16 | Buy |
| Crysdot | CD31001733 | Pentamidinedihydrochloride 98+% | 50357-45-4 | 50mg | $137 | 2021-12-16 | Buy |
| Crysdot | CD31001733 | Pentamidinedihydrochloride 98+% | 50357-45-4 | 100mg | $208 | 2021-12-16 | Buy |
PentaMidine-d4 2HCl Chemical Properties,Uses,Production
Uses
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
Safety Profile
A poison by subcutaneous and intravenous routes. When heated to decomposition it emits toxic vapors of NOx and HCl.
in vivo
Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1].
| Animal Model: | Athymic nude mice (6 weeks old) injected with WM9 cells[1] |
| Dosage: | 0.25 mg/mouse |
| Administration: | Intramuscular injection; every 2 days; for 4 weeks |
| Result: | Markedly inhibited the growth of WM9 human melanoma tumors in nude mice. |
IC 50
Trypanosoma; Leishmania
References
[1] Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PMID:12516958
[2] Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. DOI:10.1002/cbdv.200590111
[3] Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34. DOI:10.1093/clinids/7.5.625
[4] David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections J Lab Precis Med 2017;2:49.
PentaMidine-d4 2HCl Preparation Products And Raw materials
Raw materials
Preparation Products
PentaMidine-d4 2HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8496 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9679 | 58 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9748 | 58 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | Sales@changyanchem.cn | China | 5001 | 55 |
| Target molecule Corp. | 857-239-0968 | service1@targetmol.com | United States | 2559 | 60 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
View Lastest Price from PentaMidine-d4 2HCl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-05 | Pentamidine dihydrochloride
50357-45-4
|
US $50.00-128.00 / mg | 99.80% | 10g | TargetMol Chemicals Inc. |
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- Pentamidine dihydrochloride
50357-45-4
- US $50.00-128.00 / mg
- 99.80%
- TargetMol Chemicals Inc.
