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2-Chloro-N-methoxy-N-methylacetamide

2-Chloro-N-methoxy-N-methylacetamide structure

CAS No.: 67442-07-3

Chemical Name:: 2-Chloro-N-methoxy-N-methylacetamide

Synonyms: 100823;EOS-60814;2-Chloro-N-methylacetohydroxamate;N-Methyl-N-methoxy-2-chloroacetamide;2-Chloro-N-methoxy-N-methylacetamide;N-(Chloroacetyl)-N-methoxymethylamine;AcetaMide, 2-chloro-N-Methoxy-N-Methyl-;2-Chloro-N-methoxy-N-methylacetamide,97%;2-Chloro-N-methoxy-N-methylacetamide 98%;Methyl 2-Chloro-N-methylacetohydroxamate

CBNumber:: CB7265277

Molecular Formula:: C4H8ClNO2

Molecular Weight:: 137.56

MDL Number:: MFCD00134232

MOL File:: 67442-07-3.mol

MSDS File:: SDS

Last updated:2026-09-12 18:54:53

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2-Chloro-N-methoxy-N-methylacetamide Properties

Melting point	39-41 °C(lit.)
Boiling point	94-95 °C
Density	1.178±0.06 g/cm3 (20 ºC 760 Torr)
Flash point	220 °F
storage temp.	2-8°C
form	Crystals
color	White to light yellow
Water Solubility	Insoluble in water.
BRN	1924015
InChI	InChI=1S/C4H8ClNO2/c1-6(8-2)4(7)3-5/h3H2,1-2H3
InChIKey	SCOJKGRNQDKFRP-UHFFFAOYSA-N
SMILES	C(N(OC)C)(=O)CCl
CAS DataBase Reference	67442-07-3(CAS DataBase Reference)
FDA UNII	2V3FHW6LWF
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

20/21/22

Safety Statements

23-26-27-28-37/39

WGK Germany

HS Code

29241900

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral

REACH Registrations

Inactive

NFPA 704

	1
2		0

2-Chloro-N-methoxy-N-methylacetamide price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	362425	2-Chloro-N-methoxy-N-methylacetamide 98%	67442-07-3	5g	$57.6	2026-04-30	Buy
Sigma-Aldrich	362425	2-Chloro-N-methoxy-N-methylacetamide 98%	67442-07-3	25g	$245	2026-04-30	Buy
TCI Chemical	C2272	2-Chloro-N-methoxy-N-methylacetamide >98.0%(GC)	67442-07-3	5g	$39	2026-04-30	Buy
TCI Chemical	C2272	2-Chloro-N-methoxy-N-methylacetamide >98.0%(GC)	67442-07-3	25g	$118	2026-04-30	Buy
Biosynth	FC29200	2-Chloro-N-methoxy-N-methylacetamide	67442-07-3	5g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
362425	5g	$57.6	Buy
362425	25g	$245	Buy
C2272	5g	$39	Buy
C2272	25g	$118	Buy
FC29200	5g	$900	Buy

2-Chloro-N-methoxy-N-methylacetamide Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystals

Uses

2-Chloro-N-methoxy-N-methylacetamide is used in the preparation of 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and structurally related 2-alkyl-4-quinolones having biological activity, 2-(benzo[d]thiazol-2-ylsulfonyl)-N-methoxy-N-methylacetamide and α-chloro-ketone, starting reagent for the one-pot synthesis of 2-heptyl-3-hydroxyl-4(1H)-quinolone (PQS), signaling molecule in the quorum sensing of Pseudomonas aeruginosa.

General Description

2-Chloro-N-methoxy-N-methylacetamide is a Weinreb amide.

Synthesis

6638-79-5

79-04-9

67442-07-3

Example 139 Synthesis of N-methoxy-N-methylchloroacetamide: N,O-dimethylhydroxylamine hydrochloride (200 g, 2.05 mol) was dissolved in tert-butyl methyl ether (2 L), and the solution was slowly added to an aqueous solution of potassium carbonate (624 g, 4.1 mol) (2 L) that was pre-cooled to 0 °C. The reaction mixture was further cooled to -5 °C, followed by the slow dropwise addition of chloroacetyl chloride, controlling the reaction temperature to not exceed 5 °C. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature with continuous vigorous stirring for 3.5 hours. After completion of the reaction, the organic and aqueous phases were separated and the aqueous phase was extracted with tert-butyl methyl ether (3 x 1 L). All organic phases were combined, washed with saturated aqueous sodium chloride solution (2 x 1 L), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was dried under vacuum to give a white solid product (257 g, 92% yield). The product was characterized by the following data: melting point 39-40.5 °C; 1H NMR (CDCl3, 300 MHz) δ 4.24 (s, 2H), 3.74 (s, 3H), 3.22 (s, 3H); mass spectra (CI) m/z 138 (MH+); elemental analysis (C4H8ClNO2) calculated values: C, 34.92; H, 5.86; N, 10.18; measured values. 10.18; measured values: C, 35.06; H, 5.88; N, 10.23.

References

[1] Journal of the American Chemical Society,
[2] Journal of the American Chemical Society, 2009, vol. 131, p. 1077 - 1091
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 27, p. 3917 - 3920
[4] RSC Advances, 2013, vol. 3, # 26, p. 10158 - 10162
[5] Patent: EP1054881, 2008, B1. Location in patent: Page/Page column 57

2-Chloro-N-methoxy-N-methylacetamide Preparation Products And Raw materials

Raw materials

tert-Butyl methyl ether N,O-Dimethylhydroxylamine hydrochloride Chloroacetic acid N-methoxymethylamine Chloroacetyl chloride

Potassium carbonate Water

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Preparation Products

N-Methoxy-N-methyl(triphenyl-phosphoranylidene)acetamide Ethanone, 1-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-chloro- 2-iodo-N-methoxy-N-methylacetamide 2-chloro-1-(6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl)ethanone

2-Chloro-N-methoxy-N-methylacetamide Suppliers

Global Suppliers ( 252)

Supplier	Tel	Email	Country	ProdList	Advantage
Sci General Material & Chemical Ltd	021-58388037;21-58388037 13472507714	35177634@qq.com;1589045147@qq.com	China	795	55
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	1846	58
Jinan Kewei Biotechnology Co., LTD	15315592897	xmxingbjlg@163.com	China	201	58
Shanghai Ruiyi Pharmaceutical Technology Co., Ltd	021-54711706	sales5@ruiyitech.com	China	224	58
Beijing FYF Chemicals Co., Ltd	010-57903446 15869909019	168931144@qq.com	China	4995	58
Suzhou Sino Rare Chemical Co., Ltd.	0512-62857507	sales@sinorarechem.com	China	999	58
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Sci General Material & Chemical Ltd	55
Suzhou Highfine Biotech Co., Ltd	58
Jinan Kewei Biotechnology Co., LTD	58
Shanghai Ruiyi Pharmaceutical Technology Co., Ltd	58
Beijing FYF Chemicals Co., Ltd	58
Suzhou Sino Rare Chemical Co., Ltd.	58
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84

View Latest Price from 2-Chloro-N-methoxy-N-methylacetamide manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	2-CHLORO-N-METHOXY-N-METHYLACETAMIDE 67442-07-3	1KG	97.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-27	2-CHLORO-N-METHOXY-N-METHYLACETAMIDE 67442-07-3	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	2-CHLORO-N-METHOXY-N-METHYLACETAMIDE 67442-07-3	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-CHLORO-N-METHOXY-N-METHYLACETAMIDE
67442-07-3
97.0%
Shaanxi Dideu New Materials Co. Ltd

2-CHLORO-N-METHOXY-N-METHYLACETAMIDE
67442-07-3
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-CHLORO-N-METHOXY-N-METHYLACETAMIDE
67442-07-3
98%
Henan Aochuang Chemical Co.,Ltd.

2-Chloro-N-methoxy-N-methylacetamide Spectrum

2-CHLORO-N-METHOXY-N-METHYLACETAMIDE(67442-07-3)¹HNMR 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE(67442-07-3)FT-IR 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE(67442-07-3)IR 2-CHLORO-N-METHOXY-N-METHYLACETAMIDE(67442-07-3)Raman

67442-07-3 (2-Chloro-N-methoxy-N-methylacetamide) Related Search:

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N-Methylacetamide N-Methoxy-N-methylacetamide CS 722

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2-CHLORO-N-METHOXY-N-METHYLACETAMIDE, 98 % 100823 Methyl 2-Chloro-N-methylacetohydroxamate N-(Chloroacetyl)-N-methoxymethylamine AcetaMide, 2-chloro-N-Methoxy-N-Methyl- N-Methyl-N-methoxy-2-chloroacetamide 2-Chloro-N-methoxy-N-methylacetamide,97% N-(Chloroacetyl)-N-methoxymethylamine, N-(2-Chloroethanoyl)-N-methoxymethylamine 2-Chloro-N-methoxy-N-methylacetamide 98% 2-Chloro-N-methylacetohydroxamate EOS-60814 2-Chloro-N-methoxy-N-methylacetamide > 2-Chloro-N-methoxy-N-methylacetamide 2-Chloro-N-methoxy-N-methylacetamide 67442-07-3 674442-07-3 67224-07-3 C4H8ClNO2 ClCH2CONOCH3CH3 HALOGEN Organic Building Blocks Amides Building Blocks Carbonyl Compounds Halides Amides Carbonyl Compounds Organic Building Blocks