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N-Methoxy-N-methylacetamide

N-Methoxy-N-methylacetamide structure

CAS No.: 78191-00-1

Chemical Name:: N-Methoxy-N-methylacetamide

Synonyms: N-Methoxy-N-methylacetamid;N-ACETYL-N,O-DIMETHYLHYDROXYLAMINE;N-Methoxy-N-methyL;Methoxy-N-methylacetamide;N-METHOXY-N-METHLACETAMIDE;N-METHOXY-N-METHYLACETAMIDE;N-Methyl-N-methoxyacetamide;N-Methoxyl-N-methylacetamide;AcetaMide, N-Methoxy-N-Methyl-;N-Methoxy-N-methylacetamide>

CBNumber:: CB6466684

Molecular Formula:: C4H9NO2

Molecular Weight:: 103.12

MDL Number:: MFCD00060098

MOL File:: 78191-00-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:03:16

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N-Methoxy-N-methylacetamide Properties

Boiling point	152 °C (lit.)
Density	0.97 g/mL at 25 °C (lit.)
refractive index	n20/D 1.426(lit.)
Flash point	121 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
color	Colorless
Water Solubility	Soluble
InChI	InChI=1S/C4H9NO2/c1-4(6)5(2)7-3/h1-3H3
InChIKey	OYVXVLSZQHSNDK-UHFFFAOYSA-N
SMILES	C(N(OC)C)(=O)C
CAS DataBase Reference	78191-00-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

P210-P233-P240-P241-P242-P243

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Risk Statements

Safety Statements

16-24/25

RIDADR

UN 1993 3/PG 3

WGK Germany

HazardClass

PackingGroup

III

HS Code

29280000

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3

REACH Registrations

Active

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
0		0

N-Methoxy-N-methylacetamide price More Price(73)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	513253	N-Methoxy-N-methylacetamide 98%	78191-00-1	5g	$111	2026-04-30	Buy
TCI Chemical	M0919	N-Methoxy-N-methylacetamide >98.0%(GC)	78191-00-1	10g	$25	2026-04-30	Buy
TCI Chemical	M0919	N-Methoxy-N-methylacetamide >98.0%(GC)	78191-00-1	25g	$49	2026-04-30	Buy
TRC	TRC-M263295-5G	N-Methoxy-N-methylacetamide	78191-00-1	5g	$103	2026-06-03	Buy
TRC	TRC-M263295-25G	N-Methoxy-N-methylacetamide	78191-00-1	25g	$252	2026-06-03	Buy

Product number	Packaging	Price	Buy
513253	5g	$111	Buy
M0919	10g	$25	Buy
M0919	25g	$49	Buy
TRC-M263295-5G	5g	$103	Buy
TRC-M263295-25G	25g	$252	Buy

N-Methoxy-N-methylacetamide Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Uses

N-Methoxy-N-methylacetamide, is a Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.

Preparation

N-Methoxy-N-methylacetamide can be prepared by reaction of Acetyl Chloride with commercially available N,O-Dimethylhydroxylamine hydrochloride in pyridine, followed by distillation at reduced pressure (65%).

General Description

Simple Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.

Synthesis

6638-79-5

75-36-5

78191-00-1

N-Methoxy-N-methylacetamide (105) was synthesized as follows: pyridine (10 mL, 124 mmol) was slowly added dropwise to a well-stirred suspension of O,N-dimethylhydroxylamine hydrochloride (6 g, 62 mmol) and acetyl chloride (4.15 mL, 59 mmol) in dichloromethane (85 mL) under argon protection. The reaction mixture was gradually warmed to room temperature and stirred continuously for 3 hours. Subsequently, the reaction mixture was partitioned between brine (55 mL) and ether (85 mL). The aqueous phase was extracted with additional ether and the combined organic layers were dried over anhydrous sodium sulfate, concentrated and purified by reduced pressure distillation to afford Weinreb amide 105 (4.54 g, 72% yield) as a colorless liquid. The boiling point of the product was 42-44 °C/20 mmHg; IR (pure sample) showed absorption peaks located at 3497, 2971, 2941, 2824, 1663 cm-1; 1H NMR (CDCl3, 300 MHz) δ 3.62 (s, 3H), 3.11 (s, 3H), 2.05 (s, 3H); 13C NMR (CDCl3. 75.4 MHz) δ 171.8 (C), 61.0 (CH3), 31.9 (CH3), 19.6 (CH3). The spectral data of the obtained products are in agreement with literature reports.

storage

N-Methoxy-N-methylacetamide is stable but should be protected from moisture; use in a fume hood.

References

[1] Organic Letters, 2012, vol. 14, # 9, p. 2250 - 2253
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 2, p. 278 - 286
[3] Patent: EP1300403, 2003, A1
[4] Tetrahedron Letters, 1983, vol. 24, # 18, p. 1851 - 1854
[5] Tetrahedron Letters, 2007, vol. 48, # 3, p. 377 - 380

N-Methoxy-N-methylacetamide synthesis

Synthesis of N-Methoxy-N-methylacetamide from N,O-Dimethylhydroxylamine hydrochloride and Acetyl chloride

N-Methoxy-N-methylacetamide Preparation Products And Raw materials

Raw materials

Acetonoxim-o-methylether 2-Chloro-N-methoxy-N-methylacetamide Trifluoroacetophenone N-methoxymethylamine N,O-Dimethylhydroxylamine hydrochloride

1,4-Cyclohexanedione Acetyl chloride Pyridine Dichloromethane

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Preparation Products

1-(4-Fluoro-phenyl)-but-3-en-2-one 3'-BroMo-5'-(trifluoroMethyl)acetophenone, 97% 3-HEXYN-2-ONE 1-(5-Bromo-2,4-difluoro-phenyl)-ethanone 5-Bromo-2-methyl-1H-benzimidazole

5-Acetyl-2-methoxypyridine, 97% 5-Acetylindole 1-(6-chloro-2-methoxypyridin-3-yl)ethanone 1-(2-Chloro-3-fluoropyridin-4-yl)ethanone

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N-Methoxy-N-methylacetamide Suppliers

Global( 344)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Jubai Biomedical Technology Co., Ltd.	13585203734	info@jbzml.com	China	200	58
Hangzhou Baiji Biotechnology Co., LTD	13615701454	616495203@qq.com	China	24	58
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	1846	58
Hubei Yihua New Materials Technology Co., Ltd.	17754433341 18086038039	986173822@qq.com	China	946	58
Shanghai Ruiyi Pharmaceutical Technology Co., Ltd	021-54711706	sales5@ruiyitech.com	China	224	58
Shanghai Dongyue Biochem Co.,Ltd.	021-64109415转822 13512134376	amyzhang@dybiochem.com	China	34	58
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Nanjing Jubai Biomedical Technology Co., Ltd.	58
Hangzhou Baiji Biotechnology Co., LTD	58
Suzhou Highfine Biotech Co., Ltd	58
Hubei Yihua New Materials Technology Co., Ltd.	58
Shanghai Ruiyi Pharmaceutical Technology Co., Ltd	58
Shanghai Dongyue Biochem Co.,Ltd.	58
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81

View Lastest Price from N-Methoxy-N-methylacetamide manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	N-Methoxy-N-methylacetamide 78191-00-1	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-02-02	N-Methoxy-N-methylacetamide 78191-00-1	5mg	99% HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2025-04-04	N-Methoxy-N-methylacetamide 78191-00-1	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

N-Methoxy-N-methylacetamide
78191-00-1
98.0%
Shaanxi Dideu New Materials Co. Ltd

N-Methoxy-N-methylacetamide
78191-00-1
99% HPLC
Shaanxi Dideu Medichem Co. Ltd

N-Methoxy-N-methylacetamide
78191-00-1
98%
Henan Aochuang Chemical Co.,Ltd.

N-Methoxy-N-methylacetamide Spectrum

N-Methoxy-N-methylacetamide(78191-00-1)MS N-Methoxy-N-methylacetamide(78191-00-1)¹HNMR N-Methoxy-N-methylacetamide(78191-00-1)¹³CNMR N-Methoxy-N-methylacetamide(78191-00-1)IR1

78191-00-1(N-Methoxy-N-methylacetamide)Related Search:

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Fmoc-OSu Boc-Trp-OSu SMCC crosslinker

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N-ACETYL-N,O-DIMETHYLHYDROXYLAMINE N-METHOXY-N-METHYLACETAMIDE N-METHOXY-N-METHLACETAMIDE N-Methoxy-N-methylacetamide, 98 % N-Methoxy-N-methyL AcetaMide, N-Methoxy-N-Methyl- N-Methoxy-N-MethylacetaMide, 95+% N-Methoxy-N-methylacetamide N-Methyl-N-methoxyacetamide N-Methoxyl-N-methylacetamide N-Methoxy-N-MethylacetaMide, 98% 5GR N-Methoxy-N-methylacetamide≥ 98%(GC) N-Methoxy-N-methylacetamide> N-Methoxy-N-methylacetamide ISO 9001：2015 REACH N-Methoxy-N-methylacetamid Methoxy-N-methylacetamide 78191-00-1 CH3CONOCH3CH3 Organic Building Blocks Building Blocks Amides Carbonyl Compounds Hydroxylamines (O-Substituted) Hydroxylamines (N-Substituted) Hydroxylamines Hydroxylamines Hydroxylamines (N-Substituted) Hydroxylamines (O-Substituted) Amides Carbonyl Compounds Organic Building Blocks bc0001