3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile
![3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile Structure](CAS/GIF/859850-90-1.gif)
- CAS No.
- 859850-90-1
- Chemical Name:
- 3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile
- Synonyms
- 3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile;Benzonitrile,3-[(4-methyl-1-piperazinyl)methyl]-
- CBNumber:
- CB7302116
- Molecular Formula:
- C13H17N3
- Molecular Weight:
- 215.29
- MDL Number:
- MFCD07772861
- MOL File:
- 859850-90-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| HS Code | 2933599590 | |||||||||
| NFPA 704 |
|
3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR111034 | 3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile 95% | 859850-90-1 | 250mg | $41 | 2026-06-04 | Buy |
| Activate Scientific | AS42615 | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile 95% | 859850-90-1 | 1g | $55 | 2026-06-04 | Buy |
| Apolloscientific | OR111034 | 3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile 95% | 859850-90-1 | 500mg | $55 | 2026-06-04 | Buy |
| Activate Scientific | AS42615 | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile 95% | 859850-90-1 | 5g | $158 | 2026-06-04 | Buy |
| Matrix Scientific | 126990 | 3-((4-Methylpiperazin-1-yl)methyl)benzonitrile | 859850-90-1 | 1.00g | $504 | 2026-05-18 | Buy |
3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile Chemical Properties, Uses, Production
Uses
3-((4-Methylpiperazin-1-yl)methyl)benzonitrile is involved in the preparation of N-Hydroxyphenylacrylamides and N-Hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.
Synthesis
109-01-3
24964-64-5
![3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE](/CAS/GIF/859850-90-1.gif)
859850-90-1
General procedure for the synthesis of 3-((4-methylpiperazin-1-yl)methyl)benzonitrile from N-methylpiperazine and 3-cyanobenzaldehyde: Step 1: 3-Formylbenzonitrile (1.5 g, 11.45 mmol), N-methylpiperazine (1.49 g, 14.9 mmol) and sodium triacetoxyborohydride (3.63 g, 17.18 mmol) were dissolved in dichloromethane (75 ml), acetic acid (0.851 ml, 14.9 mmol) was added and the reaction was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with 1 M sodium carbonate solution. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: dichloromethane/methanol/ammonia = 97:3:0.5) to give 3-(4-methylpiperazin-1-ylmethyl)benzonitrile 1.7 g in 70% yield.
References
[1] Patent: WO2007/113249, 2007, A2. Location in patent: Page/Page column 60-61
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 822 - 839
[3] Patent: EP2033956, 2009, A1. Location in patent: Page/Page column 13
[4] Patent: WO2006/130075, 2006, A1. Location in patent: Page/Page column 25-26
3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
3-[(4-Methylpiperazin-1-yl)methyl]benzonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
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