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2-Chloro-5-nitropyridine

2-Chloro-5-nitropyridine Structure
2-Chloro-5-nitropyridine structure
CAS No.
4548-45-2
Chemical Name:
2-Chloro-5-nitropyridine
Synonyms
Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-Chlor-5-nitropyridin;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine
CBNumber:
CB8853635
Molecular Formula:
C5H3ClN2O2
Molecular Weight:
158.54
MDL Number:
MFCD00006240
MOL File:
4548-45-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:28:42
Product description Number Pack Size Price
2-Chloro-5-nitropyridine 99% C61801 5g $67.6
2-Chloro-5-nitropyridine 99% C61801 25g $143
2-Chloro-5-nitropyridine >99.0%(GC) C0025 5g $17
2-Chloro-5-nitropyridine >99.0%(GC) C0025 25g $44
2-Chloro-5-nitropyridine ≥98%(GC) 25556 25G $18.53
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2-Chloro-5-nitropyridine Properties

Melting point 105-108 °C (lit.)
Boiling point 256.6±20.0 °C(Predicted)
Density 1.6616 (rough estimate)
refractive index 1.5500 (estimate)
Flash point 158°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka -4.22±0.10(Predicted)
form Crystalline Powder
color Light yellow to beige
Water Solubility Solubility in hot methanol. Insoluble in water.
BRN 120453
InChI InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChIKey BAZVFQBTJPBRTJ-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C([N+]([O-])=O)C=C1
CAS DataBase Reference 4548-45-2(CAS DataBase Reference)
NIST Chemistry Reference 2-Chloro-5-nitropyridine(4548-45-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  US7175000
HazardClass  IRRITANT
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-5-nitropyridine price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C61801 2-Chloro-5-nitropyridine 99% 4548-45-2 5g $67.6 2026-04-30 Buy
Sigma-Aldrich C61801 2-Chloro-5-nitropyridine 99% 4548-45-2 25g $143 2026-04-30 Buy
TCI Chemical C0025 2-Chloro-5-nitropyridine >99.0%(GC) 4548-45-2 5g $17 2026-04-30 Buy
TCI Chemical C0025 2-Chloro-5-nitropyridine >99.0%(GC) 4548-45-2 25g $44 2026-04-30 Buy
Chem-Impex 25556 2-Chloro-5-nitropyridine ≥98%(GC) 4548-45-2 25G $18.53 2026-05-19 Buy
Product number Packaging Price Buy
C61801 5g $67.6 Buy
C61801 25g $143 Buy
C0025 5g $17 Buy
C0025 25g $44 Buy
25556 25G $18.53 Buy

2-Chloro-5-nitropyridine Chemical Properties,Uses,Production

Description

2-Chloro-5-nitropyridine is an important intermediate in the synthesis of many drugs, such as the antimalarial drug pyronaridine.

Chemical Properties

white to light yellow crystal

Uses

2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

Uses

2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.

Synthesis

Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.

Purification Methods

It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]

2-Chloro-5-nitropyridine synthesis

2530-26-9
4548-45-2
Synthesis of 2-Chloro-5-nitropyridine from 3-Nitropyridine

2-Chloro-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-nitropyridine Phosphorus oxitrichloride Nitric acid 2-Aminopyridine 2-Hydroxy-5-nitropyridine
2-Amino-6-chloro-3-nitropyridine 2-Chloro-5-nitropyridin-4-amine

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Preparation Products

4-(5-Nitropyridin-2-yl)morpholine 5-Nitropyridine-2-carboxylic acid 1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL 5-AMINO-2-METHOXY-ISONICOTINIC ACID 6-(1-PYRROLIDINYL)-3-PYRIDINAMINE
1-(5-aminopyridin-2-yl)piperidin-4-ol 3-Amino-6-morpholinopyridine 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE 5-NITRO-2-(1-PYRROLIDINYL)PYRIDINE 5-Amino-2-chloropyridine
5-Amino-2-methylpyridine 2-Methoxy-5-nitropyridine 3-Aminopyridine 5-Aminopyridine-2-carboxylic Acid 5-Amino-2-methoxypyridine
2-Chloro-5-nitropyridin-4-amine NVP-LDE225 2-Methyl-5-nitropyridine

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2-Chloro-5-nitropyridine Suppliers

Global( 674)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenyang TYSChem Co., Ltd.
+86-24-83607930 +8618640359690 sales@honghuchem.com China 403 58
Terma Medicare India Pvt.,Ltd
+86-53530655; +8613916485955 shivshanghai@yahoo.com India 301 58
China Synchem Technology Co.,Ltd.
+86-0552-4929304 +86-18055277008 wangxuhui1985@126.com China 65 55
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5231 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20122 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		+15184799099 lbaochemicals@gmail.com China 670 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Supplier Advantage
Shenyang TYSChem Co., Ltd.
58
Terma Medicare India Pvt.,Ltd
58
China Synchem Technology Co.,Ltd.
55
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50

Related articles

View Lastest Price from 2-Chloro-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-nitropyridine pictures 2026-05-29 2-Chloro-5-nitropyridine
4548-45-2
 1KG 98%min HPLC 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-5-nitropyridine pictures 2026-05-28 2-Chloro-5-nitropyridine
4548-45-2
 $1.00 1KG 99.% 50 ton Hebei Chuanghai Biotechnology Co,.LTD
2-Chloro-5-nitropyridine pictures 2026-05-21 2-Chloro-5-nitropyridine
4548-45-2
 $5.00 1kg ≥98% 200mt/year Jinan Finer Chemical Co., Ltd

2-Chloro-5-nitropyridine Spectrum

2-Chloro-5-nitropyridine(4548-45-2)MS2-Chloro-5-nitropyridine(4548-45-2)1HNMR2-Chloro-5-nitropyridine(4548-45-2)IR12-Chloro-5-nitropyridine(4548-45-2)IR2

4548-45-2(2-Chloro-5-nitropyridine)Related Search:

6-Chloro-2-methyl-3-nitropyridine 2-Chloro-3-cyanopyridine 2-Chloro-5-chloromethylpyridine Pentachloropyridine Clopidol
1-Chloro-3-nitrobenzene 2-Chloro-5-methylpyridine 5-Amino-2-chloropyridine 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine
3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 2-Chloro-5-hydroxypyridine 2-CHLORO-5-METHOXYPYRIDINE 2-Chloro-5-iodopyridine
5-Bromo-2-chlorobenzoic acid 2,4-DICHLORO-5-NITROPYRIDINE Difluorochloromethane

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2-Chloro-5-nitropyridine 3-Nitro-6-chloropyridine 2-Chloro-5-nitropyridine, 99% 25GR 5-Nitro-2-chloropyridine 6-Chloro-3-nitropyridine 2-Chloro-5-nitropyridine, 97+% Chloro-5-nitropyrid 2-chloro-5-nitro-pyridin Chloronitropyridine,99% 3-PYRIDINOL, 6-CHLORO- 2-choro-5-nitropyridine 2-CHLORO-5-NITROPYRIDINE (NON-REGULATED) 2-CHLORO-5-NITROPYRIDINE (REGULATED) 2-CHLORO-5-NITROPYRIDINE 99+% Chloronitropyridine 2-Chloro-5-nitropyridine > 5-Bromo-4-methyl-2(2H)-pyridinone 2-Chloro-5-nitropyridine ISO 9001：2015 REACH 4548-45-2 ISO 9001：2015 REACH 2-Chloro--nitropyridine 2-chloro-5-nitripyridine 2-Chlor-5-nitropyridin Piroctone Impurity 3 2-Chloro-5-nitropyridine, 98% 4548-45-2 4548-48-2 C5H3CIN2O2 Building Blocks Pyridines Heterocyclic Building Blocks Halogenated Heterocycles alkyl chloride |nitro-compound Chlorinated heterocyclic series Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridine series Halides Pyridines derivates Pyridines, Pyrimidines, Purines and Pteredines Heterocycles blocks Pyridines Pyridine compounds of pyridine 1 bc0001