Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Chloro-5-nitropyridine

2-Chloro-5-nitropyridine

2-Chloro-5-nitropyridine Structure
2-Chloro-5-nitropyridine structure
CAS No.
4548-45-2
Chemical Name:
2-Chloro-5-nitropyridine
Synonyms
Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-Chlor-5-nitropyridin;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine
CBNumber:
CB8853635
Molecular Formula:
C5H3ClN2O2
Molecular Weight:
158.54
MDL Number:
MFCD00006240
MOL File:
4548-45-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:28:42
Request For Quotation

2-Chloro-5-nitropyridine Properties

Melting point 105-108 °C (lit.)
Boiling point 256.6±20.0 °C(Predicted)
Density 1.6616 (rough estimate)
refractive index 1.5500 (estimate)
Flash point 158°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka -4.22±0.10(Predicted)
form Crystalline Powder
color Light yellow to beige
Water Solubility Solubility in hot methanol. Insoluble in water.
BRN 120453
InChI InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChIKey BAZVFQBTJPBRTJ-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C([N+]([O-])=O)C=C1
CAS DataBase Reference 4548-45-2(CAS DataBase Reference)
NIST Chemistry Reference 2-Chloro-5-nitropyridine(4548-45-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  US7175000
HazardClass  IRRITANT
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-5-nitropyridine price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C61801 2-Chloro-5-nitropyridine 99% 4548-45-2 5g $67.6 2026-04-30 Buy
Sigma-Aldrich C61801 2-Chloro-5-nitropyridine 99% 4548-45-2 25g $143 2026-04-30 Buy
TCI Chemical C0025 2-Chloro-5-nitropyridine >99.0%(GC) 4548-45-2 5g $17 2026-04-30 Buy
TCI Chemical C0025 2-Chloro-5-nitropyridine >99.0%(GC) 4548-45-2 25g $44 2026-04-30 Buy
Usbiological 267295 2-Chloro-5-nitropyridine Asreported 4548-45-2 50g $337 2026-06-03 Buy
Product number Packaging Price Buy
C61801 5g $67.6 Buy
C61801 25g $143 Buy
C0025 5g $17 Buy
C0025 25g $44 Buy
267295 50g $337 Buy

2-Chloro-5-nitropyridine Chemical Properties, Uses, Production

Description

2-Chloro-5-nitropyridine is an important intermediate in the synthesis of many drugs, such as the antimalarial drug pyronaridine.

Chemical Properties

white to light yellow crystal

Uses

2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

Uses

2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.

Synthesis

Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.

Purification Methods

It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]

2-Chloro-5-nitropyridine synthesis

2530-26-9
4548-45-2
Synthesis of 2-Chloro-5-nitropyridine from 3-Nitropyridine

2-Chloro-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-nitropyridine Phosphorus oxitrichloride Nitric acid 2-Aminopyridine 2-Hydroxy-5-nitropyridine
2-Amino-6-chloro-3-nitropyridine 2-Chloro-5-nitropyridin-4-amine

1of2

Preparation Products

4-(5-Nitropyridin-2-yl)morpholine 5-Nitropyridine-2-carboxylic acid 1-[5-Nitropyridin-2-yl]piperidine-4-ol 5-Amino-2-methoxy-isonicotinic acid 6-(1-Pyrrolidinyl)-3-pyridinamine
1-(5-aminopyridin-2-yl)piperidin-4-ol 3-Amino-6-morpholinopyridine 7-Chloro-10-(4-hydroxyanilino)-2-methoxy benzo(b)-1,5-naphthy ridine 5-Nitro-2-(1-pyrrolidinyl)pyridine 5-Amino-2-chloropyridine
5-Amino-2-methylpyridine 2-Methoxy-5-nitropyridine 3-Aminopyridine 5-Aminopyridine-2-carboxylic Acid 5-Amino-2-methoxypyridine
2-Chloro-5-nitropyridin-4-amine NVP-LDE225 2-Methyl-5-nitropyridine

1of4

2-Chloro-5-nitropyridine Suppliers

Global Suppliers ( 683)
Supplier Tel Email Country ProdList Advantage
Shanghai Meilv Pharmatech Co. Ltd 21-53530655 18930806002 652583651@qq.com China 307 58
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
Zhangjiagang Xikai Chemical Co.,Ltd 051255701600 13962289590 sales@xikaichem.com China 311 58
Suzhou Lakestar Pharmatech Co., Ltd. 0512-63970158-603 18018108880 info@lakestarpharma.com China 401 59
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375880 15098789112 3845379039@qq.com China 1457 58
Shanghai Kuanglin Tech LTD Co 13701867986 13701867986@163.com China 100 58
Suzhou Sino Rare Chemical Co., Ltd. 512-62857507 sales@sinorarechem.com China 1864 58
Jiangxi Bairui Technology Co., Ltd 13026208279 13026208279 bwinchem@163.com China 186 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Shanghai Meilv Pharmatech Co. Ltd 58
Shanghai Longsheng chemical Co.,Ltd. 59
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Zhangjiagang Xikai Chemical Co.,Ltd 58
Suzhou Lakestar Pharmatech Co., Ltd. 59
Jinan Dexinjia Bio&Tech Co., Ltd 58
Shanghai Kuanglin Tech LTD Co 58
Suzhou Sino Rare Chemical Co., Ltd. 58
Jiangxi Bairui Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76

Related articles

View Latest Price from 2-Chloro-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-nitropyridine pictures 2026-09-17 2-Chloro-5-nitropyridine
4548-45-2
 $5.00 1kg ≥98% 200mt/year Jinan Finer Chemical Co., Ltd
2-Chloro-5-nitropyridine pictures 2026-09-17 2-Chloro-5-nitropyridine
4548-45-2
 1KG 98%min HPLC 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-5-nitropyridine pictures 2026-09-02 2-Chloro-5-nitropyridine
4548-45-2
 $9.00 1KG 99% Henan Fengda Chemical Co., Ltd

2-Chloro-5-nitropyridine Spectrum

2-Chloro-5-nitropyridine(4548-45-2)MS2-Chloro-5-nitropyridine(4548-45-2)1HNMR2-Chloro-5-nitropyridine(4548-45-2)IR12-Chloro-5-nitropyridine(4548-45-2)IR2

4548-45-2 (2-Chloro-5-nitropyridine) Related Search:

6-Chloro-2-methyl-3-nitropyridine 2-Chloro-3-cyanopyridine 2-Chloro-5-chloromethylpyridine Pentachloropyridine Clopidol
1-Chloro-3-nitrobenzene 2-Chloro-5-methylpyridine 5-Amino-2-chloropyridine 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine
3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 2-Chloro-5-hydroxypyridine 2-Chloro-5-iodopyridine 5-Bromo-2-chlorobenzoic acid
2-Chloro-5-methoxypyridine 2,4-Dichloro-5-nitropyridine Difluorochloromethane

1of4

2-Chloro-5-nitropyridine 3-Nitro-6-chloropyridine 2-Chloro-5-nitropyridine, 99% 25GR 5-Nitro-2-chloropyridine 6-Chloro-3-nitropyridine 2-Chloro-5-nitropyridine, 97+% Chloro-5-nitropyrid 2-chloro-5-nitro-pyridin Chloronitropyridine,99% 3-PYRIDINOL, 6-CHLORO- 2-choro-5-nitropyridine 2-CHLORO-5-NITROPYRIDINE (NON-REGULATED) 2-CHLORO-5-NITROPYRIDINE (REGULATED) 2-CHLORO-5-NITROPYRIDINE 99+% Chloronitropyridine 2-Chloro-5-nitropyridine > 5-Bromo-4-methyl-2(2H)-pyridinone 2-Chloro-5-nitropyridine ISO 9001：2015 REACH 4548-45-2 ISO 9001：2015 REACH 2-Chloro--nitropyridine 2-chloro-5-nitripyridine 2-Chlor-5-nitropyridin Piroctone Impurity 3 2-Chloro-5-nitropyridine, 98% 4548-45-2 4548-48-2 C5H3CIN2O2 Building Blocks Pyridines Heterocyclic Building Blocks Halogenated Heterocycles alkyl chloride |nitro-compound Chlorinated heterocyclic series Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridine series Halides Pyridines derivates Pyridines, Pyrimidines, Purines and Pteredines Heterocycles blocks Pyridines Pyridine compounds of pyridine 1 bc0001