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2-Chloro-3-nitropyridine

2-Chloro-3-nitropyridine Structure
2-Chloro-3-nitropyridine structure
CAS No.
5470-18-8
Chemical Name:
2-Chloro-3-nitropyridine
Synonyms
AURORA KA-2997;Chloro-3-nitropyrid;oro-3-nitropyridine;2-Chloro-3-nitropyri;2-Chrolo-3-nitropyridin;3-Nitro-2-chloropyridine;2-chloro-3-nitro-pyridin;2-Chrolo-3-nitropyridine;2-CHLORO-3-NITROPYRIDINE;Pyridine, 2-chloro-3-nitro-
CBNumber:
CB9206306
Molecular Formula:
C5H3ClN2O2
Molecular Weight:
158.54
MDL Number:
MFCD00006232
MOL File:
5470-18-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:42
Product description Number Pack Size Price
2-Chloro-3-nitropyridine 99% C61607 5g $56.7
2-Chloro-3-nitropyridine 99% C61607 25g $91.4
2-Chloro-3-nitropyridine >99.0%(GC) C1008 5g $20
2-Chloro-3-nitropyridine >99.0%(GC) C1008 25g $63
2-CHLORO-3-NITROPYRIDINE 97% 22308 25G $21
More product size
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2-Chloro-3-nitropyridine Properties

Melting point 100-103 °C (lit.)
Boiling point 260.3±20.0 °C(Predicted)
Density 1.6616 (rough estimate)
refractive index 1.454-1.456
Flash point 185°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
Water Solubility Insoluble in water
pka -2.60±0.10(Predicted)
form Crystalline Powder
color Yellow
BRN 124482
InChI InChI=1S/C5H3ClN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
InChIKey UUOLETYDNTVQDY-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC=C1[N+]([O-])=O
CAS DataBase Reference 5470-18-8(CAS DataBase Reference)
NIST Chemistry Reference 2-Chloro-3-nitropyridine(5470-18-8)
EPA Substance Registry System Pyridine, 2-chloro-3-nitro- (5470-18-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P301+P312+P330-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/22-36/37/38-22
Safety Statements  22-24/25-37/39-26-36
RIDADR  UN 2811
WGK Germany  3
TSCA  TSCA listed
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29333999
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-3-nitropyridine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C61607 2-Chloro-3-nitropyridine 99% 5470-18-8 5g $56.7 2026-04-30 Buy
Sigma-Aldrich C61607 2-Chloro-3-nitropyridine 99% 5470-18-8 25g $91.4 2026-04-30 Buy
TCI Chemical C1008 2-Chloro-3-nitropyridine >99.0%(GC) 5470-18-8 5g $20 2026-04-30 Buy
TCI Chemical C1008 2-Chloro-3-nitropyridine >99.0%(GC) 5470-18-8 25g $63 2026-04-30 Buy
AstaTech 22308 2-CHLORO-3-NITROPYRIDINE 97% 5470-18-8 25G $21 2026-04-30 Buy
Product number Packaging Price Buy
C61607 5g $56.7 Buy
C61607 25g $91.4 Buy
C1008 5g $20 Buy
C1008 25g $63 Buy
22308 25G $21 Buy

2-Chloro-3-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powder

Uses

2-Chloro-3-nitropyridine is often used as a pharmaceutical intermediate.

Reactions

2-Chloro-3-nitropyridine is a nucleophilic compound that reacts with amines to form substituted amines.

Synthesis

3-NITRO-PYRIDINE-2-CARBOXYLIC ACID

59290-85-6

2-Chloro-3-nitropyridine

5470-18-8

General procedure for the synthesis of 2-chloro-3-nitropyridine from 3-nitropyridine-2-carboxylic acid: accurately weigh 3-nitropyridine-2-carboxylic acid (50.4 mg, 0.3 mmol), sodium carbonate (64.0 mg, 0.6 mmol), sodium chloride (17.6 mg, 0.3 mmol) and tert-butyl hypochlorite (32 μL, 0.3 mmol) in a 25 mL Schlenk reaction flask. Subsequently, dichloromethane (3 mL) was added as a solvent and the reaction mixture was placed in an oil bath at 25 °C for 20 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate as eluent to give 2-chloro-3-nitropyridine in 58% yield.

Purification Methods

It forms needles from H2O. Purify it by continuous sublimation over a period of 2 weeks at 50-60o/0.1mm [Barlin J Chem Soc 2150 1964]. The N-oxide has m 100o(from CH2Cl2/Et2O). [Taylor & Driscoll J Org Chem 25 1716 1960, Ochiai & Kaneko Chem Pharm Bull Jpn 8 28 1960, Beilstein 20/5 V 451.]

References

[1] Patent: CN108586334, 2018, A. Location in patent: Paragraph 0060-0062

2-Chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

3-NITRO-PYRIDINE-2-CARBOXYLIC ACID Sodium chloride Dichloromethane Sodium carbonate tert-Butyl Hypochlorite

Preparation Products

N-isopropyl-2-(piperazin-1-yl)pyridin-3-amine 4-Azaindole 1-(3-Nitorpyridin-2-yl)piperazine 2-(Piperazin-1-yl)pyridin-3-amine 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
3-AMINO-2-(2,4-DIFLUOROPHENOXY)PYRIDINE 2-HYDRAZINO-3-NITROPYRIDINE 6-Azaindole 2-Amino-3-nitropyridine 1H-INDOL-1-AMINE
3-Nitro-2-pyridinethiol 3-AMINO-PYRIDINE-2-CARBALDEHYDE 2-Methoxy-3-nitropyridine 3-Amino-2-picoline N-tert-butyl-3-nitropyridin-2-amine

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2-Chloro-3-nitropyridine Suppliers

Global( 558)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Wisdom Chemicals Co., Ltd.
+8613701363759 market@wisdomchem.com China 254 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13843 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Supplier Advantage
Beijing Wisdom Chemicals Co., Ltd.
58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58

View Lastest Price from 2-Chloro-3-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-3-nitropyridine pictures 2026-04-30 2-Chloro-3-nitropyridine
5470-18-8
 US $0.00 / Kg/Bag 1KG 98%min GC 100KGS WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-3-nitropyridine pictures 2025-12-01 2-Chloro-3-nitropyridine
5470-18-8
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chloro-3-nitropyridine pictures 2025-11-18 2-Chloro-3-nitropyridine
5470-18-8
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited

2-Chloro-3-nitropyridine Spectrum

2-Chloro-3-nitropyridine(5470-18-8)MS2-Chloro-3-nitropyridine(5470-18-8)1HNMR2-Chloro-3-nitropyridine(5470-18-8)13CNMR2-Chloro-3-nitropyridine(5470-18-8)IR12-Chloro-3-nitropyridine(5470-18-8)IR22-Chloro-3-nitropyridine(5470-18-8)Raman

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2-Chloro-3-nitropyridine, 99+% 2-CHLORO-3-NITROPYRIDINE 2-CHLORO-3-NITROPYRIDINE 2-Chloro-3-nitropyridine ,98% 2-Chloro-3-nitropyridine, 99+% 25GR 2-Chloro-3-nitropyri oro-3-nitropyridine 2-Chrolo-3-nitropyridin Chloro-3-nitropyrid 2-Chloro-3-nitropyridine≥ 98% (Assay) 2-chloro-3-nitro-pyridin 3-Nitro-2-chloropyridine Pyridine, 2-chloro-3-nitro- 2-Chrolo-3-nitropyridine 4-CHLORO-3-SULFONAMIDOPYRIDINE AURORA KA-2997 2-CHLORO-3-NITROPYRIDINE 2-Chloro-3-nitropyridine> 2-Chloro-3-nitropyridine 5470-18-8 5470-18-8 C5H3N2O2Cl Halopyridines Chloropyridines Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Building Blocks pyridine series FINE Chemical & INTERMEDIATES Pyridine Pyridines, Pyrimidines, Purines and Pteredines nitro-compound | alkyl chloride C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks bc0001