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2-Chloro-3-nitropyridine

2-Chloro-3-nitropyridine Structure
2-Chloro-3-nitropyridine structure
CAS No.
5470-18-8
Chemical Name:
2-Chloro-3-nitropyridine
Synonyms
AURORA KA-2997;Chloro-3-nitropyrid;oro-3-nitropyridine;2-Chloro-3-nitropyri;2-Chrolo-3-nitropyridin;3-Nitro-2-chloropyridine;2-chloro-3-nitro-pyridin;2-Chrolo-3-nitropyridine;2-CHLORO-3-NITROPYRIDINE;Pyridine, 2-chloro-3-nitro-
CBNumber:
CB9206306
Molecular Formula:
C5H3ClN2O2
Molecular Weight:
158.54
MDL Number:
MFCD00006232
MOL File:
5470-18-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:53:27
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2-Chloro-3-nitropyridine Properties

Melting point 100-103 °C (lit.)
Boiling point 260.3±20.0 °C(Predicted)
Density 1.6616 (rough estimate)
refractive index 1.454-1.456
Flash point 185°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
Water Solubility Insoluble in water
pka -2.60±0.10(Predicted)
form Crystalline Powder
color Yellow
BRN 124482
InChI InChI=1S/C5H3ClN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
InChIKey UUOLETYDNTVQDY-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC=C1[N+]([O-])=O
CAS DataBase Reference 5470-18-8(CAS DataBase Reference)
NIST Chemistry Reference 2-Chloro-3-nitropyridine(5470-18-8)
EPA Substance Registry System Pyridine, 2-chloro-3-nitro- (5470-18-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P301+P312+P330-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/22-36/37/38-22
Safety Statements  22-24/25-37/39-26-36
RIDADR  UN 2811
WGK Germany  3
TSCA  TSCA listed
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29333999
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Chloro-3-nitropyridine price More Price(101)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C61607 2-Chloro-3-nitropyridine 99% 5470-18-8 5g $56.7 2026-04-30 Buy
Sigma-Aldrich C61607 2-Chloro-3-nitropyridine 99% 5470-18-8 25g $91.4 2026-04-30 Buy
TCI Chemical C1008 2-Chloro-3-nitropyridine >99.0%(GC) 5470-18-8 5g $20 2026-04-30 Buy
TCI Chemical C1008 2-Chloro-3-nitropyridine >99.0%(GC) 5470-18-8 25g $63 2026-04-30 Buy
Usbiological 267451 2-Chloro-3-nitropyridine Asreported 5470-18-8 100g $375 2026-06-03 Buy
Product number Packaging Price Buy
C61607 5g $56.7 Buy
C61607 25g $91.4 Buy
C1008 5g $20 Buy
C1008 25g $63 Buy
267451 100g $375 Buy

2-Chloro-3-nitropyridine Chemical Properties, Uses, Production

Chemical Properties

yellow crystalline powder

Uses

2-Chloro-3-nitropyridine is often used as a pharmaceutical intermediate.

Reactions

2-Chloro-3-nitropyridine is a nucleophilic compound that reacts with amines to form substituted amines.

Synthesis

3-NITRO-PYRIDINE-2-CARBOXYLIC ACID

59290-85-6

2-Chloro-3-nitropyridine

5470-18-8

General procedure for the synthesis of 2-chloro-3-nitropyridine from 3-nitropyridine-2-carboxylic acid: accurately weigh 3-nitropyridine-2-carboxylic acid (50.4 mg, 0.3 mmol), sodium carbonate (64.0 mg, 0.6 mmol), sodium chloride (17.6 mg, 0.3 mmol) and tert-butyl hypochlorite (32 μL, 0.3 mmol) in a 25 mL Schlenk reaction flask. Subsequently, dichloromethane (3 mL) was added as a solvent and the reaction mixture was placed in an oil bath at 25 °C for 20 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate as eluent to give 2-chloro-3-nitropyridine in 58% yield.

Purification Methods

It forms needles from H2O. Purify it by continuous sublimation over a period of 2 weeks at 50-60o/0.1mm [Barlin J Chem Soc 2150 1964]. The N-oxide has m 100o(from CH2Cl2/Et2O). [Taylor & Driscoll J Org Chem 25 1716 1960, Ochiai & Kaneko Chem Pharm Bull Jpn 8 28 1960, Beilstein 20/5 V 451.]

References

[1] Patent: CN108586334, 2018, A. Location in patent: Paragraph 0060-0062

2-Chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

3-Nitro-pyridine-2-carboxylic acid Sodium chloride Dichloromethane Sodium carbonate tert-Butyl Hypochlorite

Preparation Products

N-isopropyl-2-(piperazin-1-yl)pyridin-3-amine 4-Azaindole 1-(3-Nitorpyridin-2-yl)piperazine 2-(Piperazin-1-yl)pyridin-3-amine 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
3-Amino-2-(2,4-difluorophenoxy)pyridine 2-Hydrazino-3-nitropyridine 6-Azaindole 2-Amino-3-nitropyridine 1H-Indol-1-amine
3-Nitro-2-pyridinethiol 3-Amino-pyridine-2-carbaldehyde 2-Methoxy-3-nitropyridine 3-Amino-2-picoline N-tert-butyl-3-nitropyridin-2-amine

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2-Chloro-3-nitropyridine Suppliers

Global Suppliers ( 561)
Supplier Tel Email Country ProdList Advantage
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Weifang Siyuan Chemical Co., Ltd. 0536-8888106 17663601818 2354379876@qq.com China 244 58
Hengshui Rayson Chemical Technology Co. , Ltd. 0318-8888981 13785822979 1532555757@qq.com China 18 58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd. 0513-82104991 18862997351 sales11@btcpharm.com China 859 58
Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd 13357739131 13357739131 3991044086@qq.com China 712 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Shanghai Longsheng chemical Co.,Ltd. 59
Weifang Siyuan Chemical Co., Ltd. 58
Hengshui Rayson Chemical Technology Co. , Ltd. 58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd. 58
Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
future industrial shanghai co., ltd 65
Alfa Aesar 84

View Latest Price from 2-Chloro-3-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-3-nitropyridine pictures 2026-09-18 2-Chloro-3-nitropyridine
5470-18-8
 1KG 98%min GC 100KGS WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-3-nitropyridine pictures 2026-09-02 2-Chloro-3-nitropyridine
5470-18-8
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Chloro-3-nitropyridine pictures 2026-08-20 2-Chloro-3-nitropyridine
5470-18-8
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited

2-Chloro-3-nitropyridine Spectrum

2-Chloro-3-nitropyridine(5470-18-8)MS2-Chloro-3-nitropyridine(5470-18-8)1HNMR2-Chloro-3-nitropyridine(5470-18-8)13CNMR2-Chloro-3-nitropyridine(5470-18-8)IR12-Chloro-3-nitropyridine(5470-18-8)IR22-Chloro-3-nitropyridine(5470-18-8)Raman

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2-Chloro-3-nitropyridine, 99+% 2-CHLORO-3-NITROPYRIDINE 2-CHLORO-3-NITROPYRIDINE 2-Chloro-3-nitropyridine ,98% 2-Chloro-3-nitropyridine, 99+% 25GR 2-Chloro-3-nitropyri oro-3-nitropyridine 2-Chrolo-3-nitropyridin Chloro-3-nitropyrid 2-Chloro-3-nitropyridine≥ 98% (Assay) 2-chloro-3-nitro-pyridin 3-Nitro-2-chloropyridine Pyridine, 2-chloro-3-nitro- 2-Chrolo-3-nitropyridine 4-CHLORO-3-SULFONAMIDOPYRIDINE AURORA KA-2997 2-CHLORO-3-NITROPYRIDINE 2-Chloro-3-nitropyridine> 2-Chloro-3-nitropyridine 5470-18-8 5470-18-8 C5H3N2O2Cl Halopyridines Chloropyridines Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Building Blocks pyridine series FINE Chemical & INTERMEDIATES Pyridine Pyridines, Pyrimidines, Purines and Pteredines nitro-compound | alkyl chloride C5 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks bc0001