FENAMIDONE
- CAS No.
- 161326-34-7
- Chemical Name:
- FENAMIDONE
- Synonyms
- REASON;UTILIS;FENOMEN;FENAMIDONE;RPA 407213;Fenamidone-[13C6];fenamidone (bsi,iso);C13408000 Fenamidone;Mepanipyrim, Pestanal;Fenamidone in Acetone
- CBNumber:
- CB7330333
- Molecular Formula:
- C17H17N3OS
- Molecular Weight:
- 311.4
- MDL Number:
- MFCD03792823
- MOL File:
- 161326-34-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 137° |
|---|---|
| Boiling point | 443.0±48.0 °C(Predicted) |
| Density | 1.285 |
| storage temp. | 0-6°C |
| pka | 0.49±0.40(Predicted) |
| Henry's Law Constant | 8.6×104 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| Major Application |
agriculture environmental |
| InChI | 1S/C17H17N3OS/c1-17(13-9-5-3-6-10-13)15(21)20(16(18-17)22-2)19-14-11-7-4-8-12-14/h3-12,19H,1-2H3/t17-/m0/s1 |
| InChIKey | LMVPQMGRYSRMIW-KRWDZBQOSA-N |
| SMILES | CSC1=N[C@](C)(C(=O)N1Nc2ccccc2)c3ccccc3 |
| LogP | 3.610 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | DN24MG2Z5E |
| Pesticides Freedom of Information Act (FOIA) | Fenamidone |
| EPA Substance Registry System | Fenamidone (161326-34-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H410 |
| Precautionary statements | P273-P280-P302+P352+P312-P362+P364-P391-P501 |
| PPE | Eyeshields, Gloves |
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN3077 9/PG 3 |
| WGK Germany | 2 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Dermal Aquatic Acute 1 Aquatic Chronic 1 |
| Toxicity | LD50 in male, female rats (mg/kg): >5000, 2028 orally; in rats (mg/kg): >2000 dermally; LC50 in bobwhite quail, mallard duck (mg/kg): >5200, >5200 dietary (Mercer) |
FENAMIDONE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 33965 | Fenamidone PESTANAL?, analytical standard | 161326-34-7 | 100mg | $78.2 | 2026-04-30 | Buy |
| aablocks | AA00AOX8 | Fenamidone | 161326-34-7 | 100mg | $278 | 2026-05-28 | Buy |
| Crysdot | CD11244059 | (S)-4-Methyl-2-(methylthio)-4-phenyl-1-(phenylamino)-1H-imidazol-5(4H)-one 95+% | 161326-34-7 | 1g | $1389 | 2026-05-26 | Buy |
| TRC | F245400 | Fenamidone | 161326-34-7 | 10mg | $85 | 2021-12-16 | Buy |
| TRC | F245400 | Fenamidone | 161326-34-7 | 50mg | $395 | 2021-12-16 | Buy |
FENAMIDONE Chemical Properties, Uses, Production
Description
Fenamidone (13; RPA 407213; (S)-5-methyl-2-methylthio- 5-phenyl-3-phenylamino-3,4-dihydroimidazol-4-one) is a complex III inhibitor that does not derive from the strobilurins but rather belongs to the imidazolinone chemical class. Fenamidone is a white woolly powder, with the following characteristics: mp = 137 C; water solubility = 7.8 mg/L; logP = 2.8, and vp = 3.4×107 Pa. It was first described by Mercer et al. (39) in 1998. Only the S-enantiomer shows antifungal activity, thus offering a reduction in application rates over the racemic mixture.
Chemical Properties
Pure product is white woolly powder, no typical odor. Relative density 1.288. vapor pressure 3.4×10-4mPa(25℃), distribution coefficient KowlgP=2.8(20℃), Henry's constant 0.5×10-5Pa -m3 /mol(20℃). Solubility in water 7.8 mg/L (20°C). Solubility in organic solvents (20℃,g/L): acetone 250, acetonitrile 86.1, dichloromethane 330, methanol 43, n-octanol 9.7.
Uses
Fungicide.
Definition
ChEBI: A member of the class of imidazolones that is 3,5-dihydroimidazol-4-one substituted at position 2 by a methylthiogroup, at position 3 by an anilino group and at position 5 by phenyl and methyl groups (the S-enantiomer). A fungicide effecti e against Oomycete diseases such as downy mildew and certain leaf spot diseases.
Production Methods
The commercial production of fenamidone involves a complex multi-step chemical synthesis. One key method includes the reaction of methyl (2S)-2-phenyl-2-(isothiocyanato)propionate with phenylhydrazine in anhydrous tetrahydrofuran under an inert argon atmosphere, followed by cooling and further processing to yield the active compound (+)-(4S)-4-methyl-2-methylthio-4-phenyl-1-phenylamino-2-imidazolin-5-one.
Hazard
Moderately toxic by ingestion and skin contact. Low toxicity by inhalation.
Mechanism of action
Protective and curative action. Respiration inhibitor (QoL fungicide).
Toxicity evaluation
Fenamidone has an acute oral LD50 > 5,000 and an acute dermal LD50 > 2,000 mg/kg in rats. Fenamidone is not a skin or eye irritant, is negative in the Ames test, and is nonteratogenic. It shows low toxicity to birds in acute and dietary studies but has a 96-h fish LC50 of 0.74 mg/L.
Pesticide Type
Fungicide
FENAMIDONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9385 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
View Latest Price from FENAMIDONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Fenamidone
161326-34-7
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Fenamidone
161326-34-7
- $1520.00-2500.00
- TargetMol Chemicals Inc.
