N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt
- CAS No.
- 2093153-09-2
- Chemical Name:
- N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt
- Synonyms
- QUN 53092;N-(Propargyl-peg4)-n-bis(peg4-acid);N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt;N-(Propargyl-peg4)-n-bis(peg4-acid) hydrochloride;4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-
- CBNumber:
- CB73373715
- Molecular Formula:
- C33H61NO16
- Molecular Weight:
- 727.83
- MDL Number:
- MFCD30723276
- MOL File:
- 2093153-09-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | bp-23506 | N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt 98% | 2093153-09-2 | 100MG | $350 | 2026-05-24 | Buy |
| BroadPharm | bp-23506 | N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt 98% | 2093153-09-2 | 250MG | $680 | 2026-05-24 | Buy |
| BroadPharm | bp-23506 | N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt 98% | 2093153-09-2 | 500MG | $1100 | 2026-05-24 | Buy |
| aablocks | AA019E8C | N-(Propargyl-peg4)-n-bis(peg4-acid) ≥95% | 2093153-09-2 | 100mg | $483 | 2026-05-29 | Buy |
| aablocks | AA019E8C | N-(Propargyl-peg4)-n-bis(peg4-acid) ≥95% | 2093153-09-2 | 250mg | $895 | 2026-05-29 | Buy |
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Chemical Properties, Uses, Production
Description
N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a branched crosslinking reagent with a propargyl group and two terminal carboxylic acids. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Preparation Products And Raw materials
Raw materials
Preparation Products
N-(Propargyl-PEG4)-N-bis(PEG4-acid) HCl salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 770406999@qq.com | China | 9949 | 58 |
| Zhejiang Rui 'ao Biological Technology Co.,LTD. | 82087565 15757883359 | yan@ruiaochem.cn | China | 712 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38904 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
